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Iichiro Shimomura

Iichiro Shimomura

D-Index & Metrics

Medicine

D-Index
128
Citations
96951
World Ranking
2641
National Ranking
47

Overview

Iichiro Shimomura is affiliated with Osaka University in Japan and has an extensive publication record in the fields of medicine and biochemistry, genetics, and molecular biology. Their primary research areas focus on endocrinology, diabetes, and metabolism, with significant contributions to molecular biology, surgery, cardiology and cardiovascular medicine, and physiology.

The scientist's work covers a broad range of topics, particularly in diabetes treatment and management, diabetes management and research, pancreatic function in diabetes, the intersection of metabolism, diabetes, and cancer, as well as adipose tissue and metabolism. Further areas of interest include adipokines, inflammation, and metabolic diseases, along with various diabetes-associated disorders.

Frequent coauthors collaborating with Shimomura include:

  • Naoto Katakami
  • Hitoshi Nishizawa
  • Hirotaka Watada
  • Junji Kozawa
  • Yuya Fujishima

Shimomura's publications have appeared repeatedly in notable scientific journals, such as:

  • Journal of Diabetes Investigation
  • Diabetology International
  • Endocrine Journal
  • Diabetes
  • Scientific Reports

Some of Shimomura's recent research papers include:

  • "Semaglutide 2·4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial," 2021, The Lancet
  • "Renal function is associated with blood neurofilament light chain level in older adults," 2020, Scientific Reports
  • "Adiponectin Stimulates Exosome Release to Enhance Mesenchymal Stem-Cell-Driven Therapy of Heart Failure in Mice," 2020, Molecular Therapy
  • "Definition, criteria, and core concepts of guidelines for the management of obesity disease in Japan," 2023, Endocrine Journal
  • "Impact of hyperuricemia on chronic kidney disease and atherosclerotic cardiovascular disease," 2022, Hypertension Research

Best Publications

  • Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.

    Yukio Arita;Shinji Kihara;Noriyuki Ouchi;Masahiko Takahashi

  • Increased oxidative stress in obesity and its impact on metabolic syndrome

    Shigetada Furukawa;Takuya Fujita;Michio Shimabukuro;Masanori Iwaki

  • cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1).

    Kazuhisa Maeda;Kousaku Okubo;Iichiro Shimomura;Tohru Funahashi

  • Diet-induced insulin resistance in mice lacking adiponectin/ACRP30.

    Norikazu Maeda;Iichiro Shimomura;Ken Kishida;Hitoshi Nishizawa

  • Visfatin: a protein secreted by visceral fat that mimics the effects of insulin.

    Atsunori Fukuhara;Morihiro Matsuda;Masako Nishizawa;Katsumori Segawa

  • PPARγ Ligands Increase Expression and Plasma Concentrations of Adiponectin, an Adipose-Derived Protein

    Norikazu Maeda;Masahiko Takahashi;Tohru Funahashi;Shinji Kihara

  • Association of Hypoadiponectinemia With Coronary Artery Disease in Men

    Masahiro Kumada;Shinji Kihara;Satoru Sumitsuji;Toshiharu Kawamoto

  • Suppression of Aging in Mice by the Hormone Klotho

    Hiroshi Kurosu;Masaya Yamamoto;Jeremy D. Clark;Johanne V. Pastor

  • Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ

    Joyce J. Repa;Guosheng Liang;Jiafu Ou;Yuriy Bashmakov

  • Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation

    Naomi Hosogai;Atsunori Fukuhara;Kazuya Oshima;Yugo Miyata

  • Adiponectin and Metabolic Syndrome

    Yuji Matsuzawa;Tohru Funahashi;Shinji Kihara;Iichiro Shimomura

  • Adiponectin Reduces Atherosclerosis in Apolipoprotein E-Deficient Mice

    Yoshihisa Okamoto;Shinji Kihara;Noriyuki Ouchi;Makoto Nishida

  • Adiponectin Stimulates Production of Nitric Oxide in Vascular Endothelial Cells

    Hui Chen;Monica Montagnani;Tohru Funahashi;Iichiro Shimomura

  • Enhanced expression of PAI-1 in visceral fat: possible contributor to vascular disease in obesity

    I Shimomura;T Funahashi;M Takahashi;K Maeda

  • Role of Adiponectin in Preventing Vascular Stenosis THE MISSING LINK OF ADIPO-VASCULAR AXIS

    Morihiro Matsuda;Iichiro Shimomura;Masataka Sata;Yukio Arita

  • Androgens Decrease Plasma Adiponectin, an Insulin-Sensitizing Adipocyte-Derived Protein

    Hitoshi Nishizawa;Iichiro Shimomura;Ken Kishida;Norikazu Maeda

  • Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

    Iichiro Shimomura;Robert E. Hammer;James A. Richardson;Shinji Ikemoto

  • Induction of Adiponectin, a Fat-Derived Antidiabetic and Antiatherogenic Factor, by Nuclear Receptors

    Masanori Iwaki;Morihiro Matsuda;Norikazu Maeda;Tohru Funahashi

  • Adipocyte-Derived Plasma Protein Adiponectin Acts as a Platelet-Derived Growth Factor-BB–Binding Protein and Regulates Growth Factor–Induced Common Postreceptor Signal in Vascular Smooth Muscle Cell

    Yukio Arita;Shinji Kihara;Noriyuki Ouchi;Kazuhisa Maeda

  • Visfatin : A protein secreted by visceral fat that mimics the effects of insulin

    Atsunori Fukuhara;Morihiro Matsuda;Masako Nishizawa;Katsumori Segawa

Frequent Co-Authors

Tohru Funahashi
Tohru Funahashi Osaka University
Shinji Kihara
Shinji Kihara Osaka University
Yuji Matsuzawa
Yuji Matsuzawa Sumitomo Hospital
Shizuya Yamashita
Shizuya Yamashita Osaka University
Hirotaka Watada
Hirotaka Watada Juntendo University
Niklas Hammar
Niklas Hammar Karolinska Institute
Yoshimitsu Yamasaki
Yoshimitsu Yamasaki Osaka University
Kamlesh Khunti
Kamlesh Khunti University of Leicester
Masatsugu Hori
Masatsugu Hori Osaka University
Noriyuki Ouchi
Noriyuki Ouchi Nagoya University

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