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Jonathan D. Smith

Jonathan D. Smith

D-Index & Metrics

Medicine

D-Index
91
Citations
44492
World Ranking
11551
National Ranking
5926

Research.com Recognitions

  • 2009 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Jonathan D. Smith is affiliated with the Cleveland Clinic in the United States. Their research spans multiple disciplines within medicine and biochemistry, genetics, and molecular biology, with a focus on areas such as molecular biology, surgery, cardiology and cardiovascular medicine, immunology, and endocrinology, diabetes, and metabolism.

The scientist's recent publications cover a diverse range of topics in biomedical research. Notable papers include:

  • SARS-CoV-2 and ACE2: The biology and clinical data settling the ARB and ACEI controversy, 2020, EBioMedicine
  • Safety and immunogenicity of PXVX0317, an aluminium hydroxide-adjuvanted chikungunya virus-like particle vaccine: a randomised, double-blind, parallel-group, phase 2 trial, 2022, The Lancet Infectious Diseases
  • IL-1 induces mitochondrial translocation of IRAK2 to suppress oxidative metabolism in adipocytes, 2020, Nature Immunology
  • Gasdermin D Mediates Inflammation-Induced Defects in Reverse Cholesterol Transport and Promotes Atherosclerosis, 2021, Frontiers in Cell and Developmental Biology
  • Genetic Susceptibility for Atrial Fibrillation in Patients Undergoing Atrial Fibrillation Ablation, 2020, Circulation Arrhythmia and Electrophysiology

Their research covers a variety of topics including inflammasome and immune disorders, diabetes and cardiovascular risks, lipoproteins and cardiovascular health, cholesterol and lipid metabolism, peroxisome proliferator-activated receptors, lipid metabolism and biosynthesis, as well as alcohol consumption and health effects.

Frequent collaborators include Mina K. Chung, David R. Van Wagoner, John Barnard, Emmanuel Opoku, and Kailash Gulshan. The scientist has contributed extensively to journals such as Heart Rhythm, bioRxiv (Cold Spring Harbor Laboratory), Circulation, Arteriosclerosis Thrombosis and Vascular Biology, and SSRN Electronic Journal.

Jonathan D. Smith was awarded the Fellow of the American Association for the Advancement of Science (AAAS) in 2009.

Best Publications

  • Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

    Zeneng Wang;Elizabeth Klipfell;Brian J. Bennett;Robert A. Koeth

  • Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis

    Robert A Koeth;Zeneng Wang;Bruce S Levison;Jennifer A Buffa

  • Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

    Andrew S. Plump;Jonathan D. Smith;Tony Hayek;Katriina Aalto-Setälä

  • Origin of the West Nile Virus Responsible for an Outbreak of Encephalitis in the Northeastern United States

    R. S. Lanciotti;J. T. Roehrig;V. Deubel;J. Smith

  • Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice

    Maria Febbraio;Eugene A. Podrez;Jonathan D. Smith;David P. Hajjar

  • Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides.

    Masaaki Miyata;Jonathan D. Smith

  • ApoE Promotes the Proteolytic Degradation of Aβ

    Qingguang Jiang;C.Y. Daniel Lee;Shweta Mandrekar;Brandy Wilkinson

  • Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E

    Jonathan D. Smith;Eugene Trogan;Michael Ginsberg;Claire Grigaux

  • Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease

    Lemin Zheng;Benedicta Nukuna;Marie Luise Brennan;Mingjiang Sun

  • Multi-Ethnic Genome-wide Association Study for Atrial Fibrillation

    Carolina Roselli;Mark D. Chaffin;Lu Chen Weng;Lu Chen Weng;Stefanie Aeschbacher

  • Meta-analysis identifies six new susceptibility loci for atrial fibrillation

    Patrick T Ellinor;Kathryn L Lunetta;Christine M Albert;Christine M Albert;Nicole L Glazer

  • Common variants in KCNN3 are associated with lone atrial fibrillation

    Patrick T. Ellinor;Kathryn L. Lunetta;Kathryn L. Lunetta;Nicole L. Glazer;Arne Pfeufer

  • γ-Butyrobetaine Is A Proatherogenic Intermediate in Gut Microbial Metabolism of L-Carnitine to TMAO

    Robert A. Koeth;Bruce S. Levison;Miranda K. Culley;Jennifer A. Buffa

  • Genome-wide association study of PR interval

    Arne Pfeufer;Charlotte Van Noord;Kristin D. Marciante;Dan E. Arking

  • T and B lymphocytes play a minor role in atherosclerotic plaque formation in the apolipoprotein E-deficient mouse

    Hayes M. Dansky;Sherri A. Charlton;Monnie McGee Harper;Jonathan D. Smith

  • High-Density Lipoprotein Function, Dysfunction, and Reverse Cholesterol Transport

    Edward A. Fisher;Jonathan E. Feig;Bernd Hewing;Stanley L. Hazen

  • An abundant dysfunctional apolipoprotein A1 in human atheroma

    Ying Huang;Joseph A DiDonato;Bruce S Levison;Dave Schmitt

  • Alcohol Consumption Raises HDL Cholesterol Levels by Increasing the Transport Rate of Apolipoproteins A-I and A-II

    Elizabeth R. De Oliveira e Silva;David Foster;Monnie McGee Harper;Cynthia E. Seidman

  • Evaluation in Nonhuman Primates of Vaccines against Ebola Virus

    Thomas W. Geisbert;Peter Pushko;Kevin Anderson;Jonathan Smith

  • Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid β peptides

    Takahiko Tokuda;Miguel Calero;Etsuro Matsubara;Ruben Vidal

Frequent Co-Authors

Stanley L. Hazen
Stanley L. Hazen Cleveland Clinic Lerner College of Medicine
Mina K. Chung
Mina K. Chung Cleveland Clinic
Steven A. Lubitz
Steven A. Lubitz Harvard University
Emelia J. Benjamin
Emelia J. Benjamin Boston University
Patrick T. Ellinor
Patrick T. Ellinor Harvard University
Bruce M. Psaty
Bruce M. Psaty University of Washington
Jan L. Breslow
Jan L. Breslow Rockefeller University
Susan R. Heckbert
Susan R. Heckbert University of Washington
Joseph A. DiDonato
Joseph A. DiDonato Cleveland Clinic
Alvaro Alonso
Alvaro Alonso Emory University

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