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D-Index & Metrics

Biology and Biochemistry

D-Index
61
Citations
24016
World Ranking
11104
National Ranking
4804

Overview

Anning Lin is affiliated with the University of Chicago in the United States. Their research focuses on the intersection of biochemistry, genetics, molecular biology, medicine, and neuroscience. Key subfields of study include molecular biology, immunology, neurology, physiology, and pathology and forensic medicine.

The scientist's work covers several main research topics: neuroinflammation and neurodegeneration mechanisms; Alzheimer's disease research and treatments; cancer mechanisms and therapy; interferon and immune responses; cancer-related gene regulation; phagocytosis and immune regulation; and inflammasome and immune disorders.

Recent publications authored or co-authored by Anning Lin include:

  • The zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation (2021, Immunity)
  • BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology (2021, iScience)
  • BAD inactivation exacerbates rheumatoid arthritis pathology by promoting survival of sublining macrophages (2020, eLife)
  • Regulation of epidermal differentiation through KDF 1-mediated deubiquitination of IKK α (2020, EMBO Reports)
  • Assessment of neurodegeneration and neuronal loss in aged 5XFAD mice (2021, STAR Protocols)

Frequent co-authors collaborating with Anning Lin include Liansheng Zhang, Xiang Yuan, Beicheng Sun, Jie Li, and Jialing Xiang.

Publication venues where Anning Lin's research has appeared frequently include Immunity, iScience, eLife, STAR Protocols, and EMBO Reports.

Best Publications

  • NF-κB at the crossroads of life and death

    Michael Karin;Anning Lin

  • Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

    M. Hibi;Anning Lin;T. Smeal;A. Minden

  • Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

    Audrey Minden;Anning Lin;François Xavier Claret;Arie Abo

  • Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

    Audrey Minden;Anning Lin;Martin McMahon;Carol Lange-Carter

  • Inhibition of JNK activation through NF-κB target genes

    Guillin Tang;Yuzuru Minemoto;Benjamin Dibling;Nicole H. Purcell

  • Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2

    Anning Lin;Audrey Minden;Horacio Martinetto;Francois Xavier Claret

  • Role of JNK activation in apoptosis: A double-edged sword

    Jing Liu;Anning Lin

  • Activation of the JNK signaling pathway: breaking the brake on apoptosis

    Anning Lin

  • c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases.

    Audrey Minden;Anning Lin;Tod Smeal;Benoit Dérijard

  • NF-κB in cancer: a marked target

    Anning Lin;Michael Karin

  • Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity.

    Anning Lin;Jeffrey A Frost;Tiliang Deng;Tod Smeal

  • Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo. A role for the caveolin-scaffolding domain.

    Jeffrey A. Engelman;Caryn Chu;Anning Lin;Hanjoong Jo

  • Activation of NF-κB is required for hypertrophic growth of primary rat neonatal ventricular cardiomyocytes

    Nicole H. Purcell;Guilin Tang;Chenfei Yu;Chenfei Yu;Frank Mercurio

  • Induction of Apoptosis by SB202190 through Inhibition of p38β Mitogen-activated Protein Kinase

    Shino Nemoto;Jialing Xiang;Shuang Huang;Anning Lin

  • JNK Suppresses Apoptosis via Phosphorylation of the Proapoptotic Bcl-2 Family Protein BAD

    Chenfei Yu;Yuzuru Minemoto;Jiyan Zhang;Jing Liu

  • Coordinate Regulation of IκB Kinases by Mitogen-Activated Protein Kinase Kinase Kinase 1 and NF-κB-Inducing Kinase

    Shino Nemoto;Joseph A. DiDonato;Anning Lin

  • Opposing Effects of Jun Kinase and p38 Mitogen-Activated Protein Kinases on Cardiomyocyte Hypertrophy

    Shino Nemoto;Zelin Sheng;Anning Lin

  • c-Jun N-terminal protein kinase 1 (JNK1), but not JNK2, is essential for tumor necrosis factor alpha-induced c-Jun kinase activation and apoptosis.

    Jing Liu;Yuzuru Minemoto;Anning Lin

  • Hydrogen Peroxide Promotes Aβ Production through JNK-dependent Activation of γ-Secretase

    Chengyong Shen;Yongfeng Chen;Huaqing Liu;Kejing Zhang

  • Novel strategies for inhibition of the p38 MAPK pathway.

    Jiyan Zhang;Beifen Shen;Anning Lin

Frequent Co-Authors

Michael Karin
Michael Karin University of California, San Diego
Masahiko Hibi
Masahiko Hibi Nagoya University
Joseph A. DiDonato
Joseph A. DiDonato Cleveland Clinic
G. R. Scott Budinger
G. R. Scott Budinger Northwestern University
Yingming Zhao
Yingming Zhao University of Chicago
David K. Ann
David K. Ann City Of Hope National Medical Center
Kwang-Jin Kim
Kwang-Jin Kim University of Southern California
Karen M. Ridge
Karen M. Ridge Northwestern University
Marsha Rich Rosner
Marsha Rich Rosner University of Chicago
Sangram S. Sisodia
Sangram S. Sisodia University of Chicago

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