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Biology and Biochemistry

D-Index
57
Citations
12844
World Ranking
13745
National Ranking
5821

Overview

Ernesto Guccione is affiliated with the Icahn School of Medicine at Mount Sinai in the United States. Their research spans multiple areas within biochemistry, genetics, molecular biology, and medicine, with a particular focus on molecular biology and cancer research. The scientist's work also touches on infectious diseases and pulmonary and respiratory medicine.

The main fields of study for Ernesto Guccione include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these domains, their subfields of study emphasize:

  • Molecular Biology
  • Cancer Research
  • Oncology
  • Infectious Diseases
  • Pulmonary and Respiratory Medicine

The primary topics covered in their research are:

  • RNA modifications and cancer
  • Cancer-related gene regulation
  • RNA Research and Splicing
  • Epigenetics and DNA Methylation
  • Ubiquitin and proteasome pathways
  • SARS-CoV-2 and COVID-19 Research
  • Protein Degradation and Inhibitors

Ernesto Guccione has contributed to numerous scientific publications. Frequent venues where their work appears include:

  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Journal of Hepatology
  • Cell

Notable recent papers authored or co-authored by Ernesto Guccione comprise:

  • "Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis" (2020, Cancer Cell)
  • "Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition" (2020, Cell)
  • "Novel microenvironment-based classification of intrahepatic cholangiocarcinoma with therapeutic implications" (2022, Gut)
  • "Differential effects of the second SARS-CoV-2 mRNA vaccine dose on T cell immunity in naive and COVID-19 recovered individuals" (2021, Cell Reports)
  • "TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation" (2021, Cell)

Collaborations have been frequent with several researchers, including:

  • Alexander Rialdi
  • Tommaso Tabaglio
  • Megan Schwarz
  • Slim Mzoughi
  • Josep M. Llovet

Best Publications

  • The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism

    Carlos Sebastián;Bernardette M. M. Zwaans;Dafne Magali Silberman;Dafne Magali Silberman;Melissa Gymrek

  • Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive.

    Ernesto Guccione;Christian Bassi;Fabio Casadio;Francesca Martinato

  • Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis

    Arianna Sabò;Arianna Sabò;Theresia R. Kress;Theresia R. Kress;Mattia Pelizzola;Stefano de Pretis

  • The regulation, functions and clinical relevance of arginine methylation.

    Ernesto Guccione;Stéphane Richard

  • Myc-binding-site recognition in the human genome is determined by chromatin context

    Ernesto Guccione;Francesca Martinato;Giacomo Finocchiaro;Lucilla Luzi

  • MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis

    Cheryl M. Koh;Marco Bezzi;Diana H P Low;Wei X ia Ang

  • Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance

    Valentina Migliori;Julius Müller;Sameer Phalke;Diana Low

  • Chromatin and Transcription Transitions of Mammalian Adult Germline Stem Cells and Spermatogenesis

    Saher Sue Hammoud;Diana H.P. Low;Diana H.P. Low;Chongil Yi;Douglas T. Carrell

  • Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery

    Marco Bezzi;Shun Xie Teo;Julius Muller;Wei Chuen Mok

  • Oncogenic human papillomavirus E6 proteins target the MAGI-2 and MAGI-3 proteins for degradation.

    Miranda Thomas;Richard Laura;Karin Hepner;Ernesto Guccione

  • Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia.

    Anna Migliazza;Francesc Bosch;Francesc Bosch;Francesc Bosch;Hirokazu Komatsu;Hirokazu Komatsu;Hirokazu Komatsu;Eftihia Cayanis;Eftihia Cayanis;Eftihia Cayanis

  • Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis.

    Douglas Hanniford;Alejandro Ulloa-Morales;Alcida Karz;Maria Gabriela Berzoti-Coelho;Maria Gabriela Berzoti-Coelho

  • Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation.

    Jia Yi Fong;Jia Yi Fong;Luca Pignata;Luca Pignata;Pierre-Alexis Goy;Pierre-Alexis Goy;Kimihito Cojin Kawabata

  • PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells.

    Athena Georgilis;Sabrina Klotz;Christopher J. Hanley;Nicolas Herranz

  • Trained immunity in newborn infants of HBV-infected mothers

    Michelle Hong;Elena Sandalova;Diana Low;Adam J. Gehring

  • The Ankrd2 Protein, a Link Between the Sarcomere and the Nucleus in Skeletal Muscle

    Snezana Kojic;Elisa Medeot;Ernesto Guccione;Helena Krmac

  • PRMT5 Is a Critical Regulator of Breast Cancer Stem Cell Function via Histone Methylation and FOXP1 Expression

    Kelly Chiang;Agnieszka E. Zielinska;Abeer M. Shaaban;Maria Pilar Sanchez-Bailon

  • Discovery of a first-in-class EZH2 selective degrader.

    Anqi Ma;Elias Stratikopoulos;Kwang-Su Park;Jieli Wei

  • Single-Cell Profiling of Epigenetic Modifiers Identifies PRDM14 as an Inducer of Cell Fate in the Mammalian Embryo

    Adam Burton;Julius Muller;Shengjiang Tu;Pablo Padilla-Longoria

  • Antisense oligonucleotide-mediated MDM4 exon 6 skipping impairs tumor growth.

    Michael Dewaele;Tommaso Tabaglio;Tommaso Tabaglio;Karen Willekens;Marco Bezzi;Marco Bezzi

Frequent Co-Authors

Bruno Amati
Bruno Amati European Institute of Oncology
Antonio Bertoletti
Antonio Bertoletti Duke NUS Graduate Medical School
Philipp Kaldis
Philipp Kaldis Lund University
Lawrence Banks
Lawrence Banks International Centre for Genetic Engineering and Biotechnology
Reshma Taneja
Reshma Taneja National University of Singapore
Vinay Tergaonkar
Vinay Tergaonkar Agency for Science, Technology and Research
Jian Jin
Jian Jin Icahn School of Medicine at Mount Sinai
Masoud Vedadi
Masoud Vedadi Structural Genomics Consortium
Cheryl H. Arrowsmith
Cheryl H. Arrowsmith Structural Genomics Consortium
Matthew T. Weirauch
Matthew T. Weirauch Cincinnati Children's Hospital Medical Center

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