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Philipp Holliger

D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
14065
World Ranking
15975
National Ranking
1257

Philipp Holliger publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Philipp Holliger sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 137 publications — 20th percentile

20% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Philipp Holliger D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Philipp Holliger sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 53 D-Index — 19th percentile

19% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Research.com Recognitions

  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Philipp Holliger is affiliated with the MRC Laboratory of Molecular Biology in the United Kingdom. Their research primarily falls under the broad field of Biochemistry, Genetics and Molecular Biology, with a focus on Molecular Biology, Genetics, and areas intersecting with Ecology, Astronomy and Astrophysics, as well as Radiology, Nuclear Medicine and Imaging.

The main topics addressed in their work include:

  • RNA and protein synthesis mechanisms
  • Advanced biosensing and bioanalysis techniques
  • DNA and Nucleic Acid Chemistry
  • Bacteriophages and microbial interactions
  • Origins and Evolution of Life
  • Bacterial Genetics and Biotechnology
  • CRISPR and Genetic Engineering

Philipp Holliger has contributed to the scientific community through various recent papers, notable examples being:

  • "Modified nucleic acids: replication, evolution, and next-generation therapeutics," 2020, published in BMC Biology
  • "Discovery and evolution of RNA and XNA reverse transcriptase function and fidelity," 2020, published in Nature Chemistry
  • "A modular XNAzyme cleaves long, structured RNAs under physiological conditions and enables allele-specific gene silencing," 2022, published in Nature Chemistry
  • "Rapid discovery of high-affinity antibodies via massively parallel sequencing, ribosome display and affinity screening," 2023, published in Nature Biomedical Engineering
  • "A two-residue nascent-strand steric gate controls synthesis of 2'-O-methyl- and 2'-O-(2-methoxyethyl)-RNA," 2022, published in Nature Chemistry

The venues most frequently publishing their research include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Chemistry
  • Nucleic Acids Research
  • RSC Chemical Biology
  • BMC Biology

Collaborations are an important aspect of their work, with several frequent coauthors recorded, including:

  • Alexander I. Taylor
  • Emil L. Kristoffersen
  • Edoardo Gianni
  • Piet Herdewijn
  • Ebbe Sloth Andersen

Philipp Holliger is recognized as a member of the European Molecular Biology Organization (EMBO).

Best Publications

  • Engineered antibody fragments and the rise of single domains

    Philipp Holliger;Peter J Hudson

  • "Diabodies": small bivalent and bispecific antibody fragments

    Philipp Holliger;Terence Prospero;Greg Winter

  • Synthetic genetic polymers capable of heredity and evolution

    Vitor B. Pinheiro;Alexander I. Taylor;Christopher Cozens;Mikhail Abramov

  • Directed evolution of polymerase function by compartmentalized self-replication

    Farid J. Ghadessy;Jennifer L. Ong;Philipp Holliger

  • Mimicking Somatic Hypermutation: Affinity Maturation of Antibodies Displayed on Bacteriophage Using a Bacterial Mutator Strain

    Nigel M. Low;Philipp Holliger;Greg Winter

  • Ribozyme-catalyzed transcription of an active ribozyme.

    Aniela Wochner;James Attwater;Alan Coulson;Philipp Holliger

  • The C-Terminal Domain of TolA Is the Coreceptor for Filamentous Phage Infection of E. coli

    Lutz Riechmann;Philipp Holliger

  • Catalysts from synthetic genetic polymers

    Alexander I. Taylor;Vitor B. Pinheiro;Vitor B. Pinheiro;Matthew J. Smola;Alexey S. Morgunov

  • In-ice evolution of RNA polymerase ribozyme activity

    James Attwater;Aniela Wochner;Philipp Holliger

  • Crystal structure of a diabody, a bivalent antibody fragment.

    Olga Perisic;Philip A Webb;Philipp Holliger;Greg Winter

  • Generic expansion of the substrate spectrum of a DNA polymerase by directed evolution.

    Farid J Ghadessy;Nicola Ramsay;François Boudsocq;David Loakes

  • The XNA world: progress towards replication and evolution of synthetic genetic polymers

    Vitor B Pinheiro;Philipp Holliger

  • Ice as a protocellular medium for RNA replication

    James Attwater;Aniela Wochner;Vitor B. Pinheiro;Alan Coulson

  • Methods of increasing the concentration of a nucleic acid

    Phillip Hollinger;Farid Ghadassy;Jennifer Lee Ong

  • Directed Evolution of DNA Polymerase, RNA Polymerase and Reverse Transcriptase Activity in a Single Polypeptide

    Jennifer L. Ong;David Loakes;Szymon Jaroslawski;Kathleen Too

  • Molecular breeding of polymerases for amplification of ancient DNA

    Marc d'Abbadie;Michael Hofreiter;Alexandra Vaisman;David Loakes

  • Improved tumour targeting by disulphide stabilized diabodies expressed in Pichia pastoris.

    Kevin FitzGerald;Philipp Holliger;Greg Winter

  • Carcinoembryonic antigen (CEA)-specific T-cell activation in colon carcinoma induced by anti-CD3 x anti-CEA bispecific diabodies and B7 x anti-CEA bispecific fusion proteins.

    Philipp Holliger;Oliver Manzke;Mary Span;Robert Hawkins

  • Crystal structure of the two N-terminal domains of g3p from filamentous phage fd at 1.9 Å: evidence for conformational lability

    Philipp Holliger;Lutz Riechmann;Roger L Williams

  • Specific killing of lymphoma cells by cytotoxic T-cells mediated by a bispecific diabody

    Philipp Holliger;Jan Brissinck;Roger L. Williams;Kris Thielemans

Frequent Co-Authors

Piet Herdewijn
Piet Herdewijn KU Leuven
Greg Winter
Greg Winter University of Cambridge
Roger L. Williams
Roger L. Williams University of Cambridge
Roger Woodgate
Roger Woodgate National Institutes of Health
Jesper Wengel
Jesper Wengel Aalborg University
Eric T. Kool
Eric T. Kool Stanford University
Kevin M. Weeks
Kevin M. Weeks University of North Carolina at Chapel Hill
Michael Hofreiter
Michael Hofreiter University of Potsdam
Hennie R. Hoogenboom
Hennie R. Hoogenboom Maastricht University
Alan Coulson
Alan Coulson Wellcome Sanger Institute

External Links

Personal website of Philipp Holliger

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Best Scientists Citing Philipp Holliger

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Publications: 59

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Broad Institute

Publications: 34

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Publications: 33

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Michal Hocek

Czech Academy of Sciences

Publications: 32

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Andreas Marx

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Publications: 31

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Pennsylvania State University

Publications: 29

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Publications: 29

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Publications: 29

Andrew D. Ellington

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The University of Texas at Austin

Publications: 29

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Publications: 25

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John R. Desjarlais

Pennsylvania State University

Publications: 23

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Publications: 22

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