Philipp Holliger

Research.com Recognitions

• Member of the European Molecular Biology Organization (EMBO)
• Member of the European Molecular Biology Organization (EMBO)
• Member of the European Molecular Biology Organization (EMBO)

Overview

Best Publications

• Engineered antibody fragments and the rise of single domains

  Philipp Holliger;Peter J Hudson

  2508
  Citations

• "Diabodies": small bivalent and bispecific antibody fragments

  Philipp Holliger;Terence Prospero;Greg Winter

  1916
  Citations

• Synthetic genetic polymers capable of heredity and evolution

  Vitor B. Pinheiro;Alexander I. Taylor;Christopher Cozens;Mikhail Abramov

  791
  Citations

• Directed evolution of polymerase function by compartmentalized self-replication

  Farid J. Ghadessy;Jennifer L. Ong;Philipp Holliger

  577
  Citations

• Mimicking Somatic Hypermutation: Affinity Maturation of Antibodies Displayed on Bacteriophage Using a Bacterial Mutator Strain

  Nigel M. Low;Philipp Holliger;Greg Winter

  501
  Citations

• Ribozyme-catalyzed transcription of an active ribozyme.

  Aniela Wochner;James Attwater;Alan Coulson;Philipp Holliger

  450
  Citations

• The C-Terminal Domain of TolA Is the Coreceptor for Filamentous Phage Infection of E. coli

  Lutz Riechmann;Philipp Holliger

  318
  Citations

• Catalysts from synthetic genetic polymers

  Alexander I. Taylor;Vitor B. Pinheiro;Vitor B. Pinheiro;Matthew J. Smola;Alexey S. Morgunov

  297
  Citations

• In-ice evolution of RNA polymerase ribozyme activity

  James Attwater;Aniela Wochner;Philipp Holliger

  297
  Citations

• Crystal structure of a diabody, a bivalent antibody fragment.

  Olga Perisic;Philip A Webb;Philipp Holliger;Greg Winter

  252
  Citations

• Generic expansion of the substrate spectrum of a DNA polymerase by directed evolution.

  Farid J Ghadessy;Nicola Ramsay;François Boudsocq;David Loakes

  229
  Citations

• The XNA world: progress towards replication and evolution of synthetic genetic polymers

  Vitor B Pinheiro;Philipp Holliger

  194
  Citations

• Ice as a protocellular medium for RNA replication

  James Attwater;Aniela Wochner;Vitor B. Pinheiro;Alan Coulson

  178
  Citations

• Methods of increasing the concentration of a nucleic acid

  Phillip Hollinger;Farid Ghadassy;Jennifer Lee Ong

  165
  Citations

• Directed Evolution of DNA Polymerase, RNA Polymerase and Reverse Transcriptase Activity in a Single Polypeptide

  Jennifer L. Ong;David Loakes;Szymon Jaroslawski;Kathleen Too

  157
  Citations

• Molecular breeding of polymerases for amplification of ancient DNA

  Marc d'Abbadie;Michael Hofreiter;Alexandra Vaisman;David Loakes

  150
  Citations

• Improved tumour targeting by disulphide stabilized diabodies expressed in Pichia pastoris.

  Kevin FitzGerald;Philipp Holliger;Greg Winter

  148
  Citations

• Carcinoembryonic antigen (CEA)-specific T-cell activation in colon carcinoma induced by anti-CD3 x anti-CEA bispecific diabodies and B7 x anti-CEA bispecific fusion proteins.

  Philipp Holliger;Oliver Manzke;Mary Span;Robert Hawkins

  148
  Citations

• Crystal structure of the two N-terminal domains of g3p from filamentous phage fd at 1.9 Å: evidence for conformational lability

  Philipp Holliger;Lutz Riechmann;Roger L Williams

  148
  Citations

• Specific killing of lymphoma cells by cytotoxic T-cells mediated by a bispecific diabody

  Philipp Holliger;Jan Brissinck;Roger L. Williams;Kris Thielemans

  145
  Citations