What is she best known for?
The fields of study she is best known for:
Her primary areas of investigation include Biochemistry, Molecular biology, Stereochemistry, Mutant and Escherichia coli.
Her study in Biochemistry focuses on Inclusion bodies, Protein folding, Native state, Plasma protein binding and Tryptophan.
Her studies in Molecular biology integrate themes in fields like MHC class I, Leukocyte Immunoglobulin-like Receptor B1, Antigen, Immunoassay and HLA-G.
Her Stereochemistry research is multidisciplinary, incorporating elements of Residue, Site-directed mutagenesis, Conformational entropy, Protein structure and Methionine.
As part of one scientific family, Izumi Kumagai deals mainly with the area of Mutant, narrowing it down to issues related to the Lysozyme, and often Monoclonal antibody, Antibody, Isothermal titration calorimetry, Enzyme and Molecule.
Her Escherichia coli research integrates issues from Urea, Recombinant DNA, Guanidine, Green fluorescent protein and Chromatography.
Her most cited work include:
- Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G (438 citations)
- Fucose Depletion from Human IgG1 Oligosaccharide Enhances Binding Enthalpy and Association Rate Between IgG1 and FcγRIIIa (380 citations)
- Practical considerations in refolding proteins from inclusion bodies (370 citations)
What are the main themes of her work throughout her whole career to date?
The scientist’s investigation covers issues in Biochemistry, Antibody, Molecular biology, Antigen and Escherichia coli.
Biochemistry and Stereochemistry are commonly linked in her work.
Her Antibody research incorporates elements of Receptor, Epidermal growth factor receptor and Cancer immunotherapy.
Her research in Molecular biology intersects with topics in Cell culture, Expression vector, Complementary DNA, Fusion protein and Cytotoxicity.
The Antigen study combines topics in areas such as Cytotoxic T cell, Cancer research and Monoclonal antibody.
Her Lysozyme research is multidisciplinary, relying on both Isothermal titration calorimetry and Mutant, Site-directed mutagenesis.
She most often published in these fields:
- Biochemistry (35.67%)
- Antibody (30.18%)
- Molecular biology (28.96%)
What were the highlights of her more recent work (between 2011-2021)?
- Antibody (30.18%)
- Nanotechnology (7.32%)
- Molecular biology (28.96%)
In recent papers she was focusing on the following fields of study:
Her primary scientific interests are in Antibody, Nanotechnology, Molecular biology, Biophysics and Epidermal growth factor receptor.
Izumi Kumagai has included themes like Cancer cell, Cytotoxic T cell, Cancer research and Biochemistry in her Antibody study.
Her work carried out in the field of Cancer research brings together such families of science as Epitope, Antigen, Receptor and T cell.
Izumi Kumagai has researched Biochemistry in several fields, including Cell culture and Imide.
Her Molecular biology research includes elements of Growth factor receptor, Mutant, Expression vector and Function.
Her Biophysics study combines topics in areas such as Proteases, Point mutation, Hinge, Biological activity and Surface plasmon resonance.
Between 2011 and 2021, her most popular works were:
- Effective treatment of an orthotopic xenograft model of human glioblastoma using an EGFR-retargeted oncolytic herpes simplex virus (72 citations)
- Enhancement of sialylation on humanized IgG-like bispecific antibody by overexpression of α2,6-sialyltransferase derived from Chinese hamster ovary cells. (38 citations)
- Domain order of a bispecific diabody dramatically enhances its antitumor activity beyond structural format conversion: the case of the hEx3 diabody. (32 citations)
In her most recent research, the most cited papers focused on:
Antibody, Molecular biology, Cell culture, Epidermal growth factor receptor and Nanotechnology are her primary areas of study.
Her study in Antibody is interdisciplinary in nature, drawing from both CD3 and Cytotoxicity.
Her work deals with themes such as Cell cycle, Clone, Mutant and Expression vector, which intersect with Molecular biology.
Her Epidermal growth factor receptor study also includes
- Cancer immunotherapy that connect with fields like Biophysics,
- Function, which have a strong connection to Pharmacokinetics, In vitro, Panitumumab, In vivo and Fragment crystallizable region.
Her research on Chinese hamster ovary cell concerns the broader Biochemistry.
Her Biochemistry study frequently draws connections between adjacent fields such as Chemical engineering.
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