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Roland E. Kontermann

Roland E. Kontermann

D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
15119
World Ranking
9153
National Ranking
663

Overview

Roland E. Kontermann is affiliated with the University of Stuttgart in Germany and has contributed extensively to the fields of medicine and biochemistry, genetics, and molecular biology. Their research spans multiple subfields including molecular biology, radiology, nuclear medicine and imaging, oncology, immunology, and biomedical engineering.

The scientist's primary research topics include monoclonal and polyclonal antibodies, CAR-T cell therapy, glycosylation and glycoproteins, nanofabrication and lithography techniques, neuroinflammation and neurodegeneration mechanisms, cell death mechanisms and regulation, and peptidase inhibition and analysis.

Notable recent papers authored or co-authored by Roland E. Kontermann include:

  • The present and future of bispecific antibodies for cancer therapy (2024, Nature Reviews Drug Discovery)
  • Selective Targeting of TNF Receptors as a Novel Therapeutic Approach (2020, Frontiers in Cell and Developmental Biology)
  • TNF-Receptor-1 inhibition reduces liver steatosis, hepatocellular injury and fibrosis in NAFLD mice (2020, Cell Death and Disease)
  • Bispecific antibodies (2021, Science)
  • OMTX705, a Novel FAP-Targeting ADC Demonstrates Activity in Chemotherapy and Pembrolizumab-Resistant Solid Tumor Models (2020, Clinical Cancer Research)

Roland E. Kontermann collaborates frequently with other researchers. The most frequent co-authors include Oliver Seifert, Klaus Pfizenmaier, Roman Fischer, Nadine Aschmoneit, and Lennart Kühl.

Their work has been published in a variety of venues, with the most common publication outlets being mAbs, Journal of Neuroinflammation, Scientific Reports, Cancer Research, and Cell Death and Disease.

Best Publications

  • Isolation of high affinity human antibodies directly from large synthetic repertoires.

    A D Griffiths;S C Williams;O Hartley;I M Tomlinson

  • The making of bispecific antibodies

    Ulrich Brinkmann;Roland E. Kontermann

  • Strategies for extended serum half-life of protein therapeutics

    Roland E Kontermann

  • Dual targeting strategies with bispecific antibodies

    Roland E Kontermann

  • Recombinant bispecific antibodies for cancer therapy

    Roland E Kontermann

  • Improved Pharmacokinetics of Recombinant Bispecific Antibody Molecules by Fusion to Human Serum Albumin

    Dafne Müller;Anette Karle;Bettina Meissburger;Ines Höfig

  • Strategies to Extend Plasma Half-Lives of Recombinant Antibodies

    Roland E. Kontermann

  • Bispecific antibodies for cancer immunotherapy: Current perspectives.

    Dafne Müller;Roland E. Kontermann

  • Targeting of immunoliposomes to endothelial cells using a single-chain Fv fragment directed against human endoglin (CD105).

    Tina Völkel;Peter Hölig;Thomas Merdan;Rolf Müller

  • Half-life extended biotherapeutics

    Roland E Kontermann

  • A novel tri-functional antibody fusion protein with improved pharmacokinetic properties generated by fusing a bispecific single-chain diabody with an albumin-binding domain from streptococcal protein G.

    Roland Stork;Dafne Müller;Roland E. Kontermann

  • Recombinant single-chain Fv fragments carrying C-terminal cysteine residues: production of bivalent and biotinylated miniantibodies.

    Sergey M. Kipriyanov;Stefan Dübel;Frank Breitling;Roland E. Kontermann

  • Generation of angiostatin-like fragments from plasminogen by prostate-specific antigen

    H. H. Heidtmann;Dirk M. Nettelbeck;A. Mingels;R. Jäger

  • Specific gene transfer to neurons, endothelial cells and hematopoietic progenitors with lentiviral vectors

    Brigitte Anliker;Tobias Abel;Sabrina Kneissl;Juraj Hlavaty

  • Novel RGD lipopeptides for the targeting of liposomes to integrin-expressing endothelial and melanoma cells

    Peter Hölig;Miriam Bach;Tina Völkel;Thomas Nahde

  • Targeting of adenovirus to endothelial cells by a bispecific single-chain diabody directed against the adenovirus fiber knob domain and human endoglin (CD105).

    Dirk M. Nettelbeck;Daniel W. Miller;Valérie Jérôme;Marylou Zuzarte

  • Selective Targeting of TNF Receptors as a Novel Therapeutic Approach

    Roman Fischer;Roland E Kontermann;Klaus Pfizenmaier

  • Bifunctional and multimeric complexes of streptavidin fused to single chain antibodies (scFv)

    S. Dübel;F. Breitling;R. Kontermann;T.G. Schmidt

  • Novel tetravalent and bispecific IgG-like antibody molecules combining single-chain diabodies with the immunoglobulin γ1 Fc or CH3 region

    Margitta Alt;Rolf Müller;Roland E Kontermann

  • A strategy of exon shuffling for making large peptide repertoires displayed on filamentous bacteriophage.

    Igor Fisch;Roland E. Kontermann;Ricarda Finnern;Oliver Hartley

Frequent Co-Authors

Klaus Pfizenmaier
Klaus Pfizenmaier University of Stuttgart
Rolf Müller
Rolf Müller Saarland University
Peter Scheurich
Peter Scheurich University of Stuttgart
Stefan Dübel
Stefan Dübel Technische Universität Braunschweig
Ekkehard K. F. Bautz
Ekkehard K. F. Bautz Heidelberg University
Andreas Herrmann
Andreas Herrmann RWTH Aachen University
Andreas Herrmann
Andreas Herrmann Humboldt-Universität zu Berlin
John R. Bethea
John R. Bethea George Washington University
Ugur Sahin
Ugur Sahin Johannes Gutenberg University of Mainz
Ulrich Brinkmann
Ulrich Brinkmann Roche (Switzerland)

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