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Richard H. Karas

Richard H. Karas

D-Index & Metrics

Medicine

D-Index
89
Citations
37540
World Ranking
12502
National Ranking
6404

Overview

Richard H. Karas is affiliated with Tufts University in the United States and has contributed extensively to the field of medicine, with a primary focus on cardiology and cardiovascular medicine. Their research portfolio includes 24 publications in medicine, with significant emphasis on cardiology and cardiovascular medicine, molecular biology, pathology and forensic medicine, surgery, and biomedical engineering.

The main topics covered in Karas's research are:

  • Cardiac Ischemia and Reperfusion
  • Mechanical Circulatory Support Devices
  • Phosphodiesterase Function and Regulation
  • Heart Failure Treatment and Management
  • Cardiovascular Function and Risk Factors
  • Peripheral Artery Disease Management
  • Fuel Cells and Related Materials

Recent papers include:

  • Transvalvular Ventricular Unloading Before Reperfusion in Acute Myocardial Infarction (2020), published in Journal of the American College of Cardiology
  • Estrogen Receptor-α Non-Nuclear Signaling Confers Cardioprotection and Is Essential to cGMP-PDE5 Inhibition Efficacy (2020), published in JACC Basic to Translational Science
  • CRD-733, a Novel PDE9 (Phosphodiesterase 9) Inhibitor, Reverses Pressure Overload-Induced Heart Failure (2021), published in Circulation Heart Failure
  • The mitochondrial regulator PGC1α is induced by cGMP-PKG signaling and mediates the protective effects of phosphodiesterase 5 inhibition in heart failure (2021), published in FEBS Letters
  • Delaying reperfusion plus left ventricular unloading reduces infarct size: Sub-analysis of DTU-STEMI pilot study (2023), published in Cardiovascular Revascularization Medicine

The venues where Karas has frequently published are:

  • Journal of the American College of Cardiology (5 publications)
  • Circulation (3 publications)
  • Cardiovascular Revascularization Medicine (2 publications)
  • JACC Basic to Translational Science (1 publication)
  • Circulation Heart Failure (1 publication)

Frequent co-authors in Karas's research include:

  • Navin K. Kapur
  • James E. Udelson
  • Jeffrey W. Moses
  • Haroon Faraz
  • Lija Swain

The scientist's work intersects various disciplines such as cardiology, molecular biology, pathology, surgery, and biomedical engineering, with particular concentration on mechanisms related to cardiac ischemia, heart failure, and phosphodiesterase regulation. Their recent focus appears to involve exploring molecular signaling pathways and interventions aimed at improving outcomes in cardiovascular diseases through pharmacological and mechanical support strategies.

Best Publications

  • The protective effects of estrogen on the cardiovascular system

    Michael E. Mendelsohn;Richard H. Karas

  • Statin-Associated Myopathy

    Paul D. Thompson;Priscilla Clarkson;Richard H. Karas

  • Molecular and cellular basis of cardiovascular gender differences

    Michael E. Mendelsohn;Richard H. Karas

  • Estrogen receptor α mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen

    Zhong Chen;Ivan S. Yuhanna;Zoya Galcheva-Gargova;Richard H. Karas

  • Assessment of peripheral vascular endothelial function with finger arterial pulse wave amplitude

    Jeffrey T Kuvin;Ayan R Patel;Kathleen A Sliney;Natesa G Pandian

  • A transcriptionally active DNA-binding site for human p53 protein complexes.

    Walter D. Funk;Daniel T. Pak;Richard H. Karas;Woodring E. Wright

  • Postmenopausal Hormone Therapy: An Endocrine Society Scientific Statement

    Richard J. Santen;D. Craig Allred;Stacy P. Ardoin;David F. Archer

  • Human vascular smooth muscle cells contain functional estrogen receptor

    R H Karas;B L Patterson;M E Mendelsohn

  • Abnormal Vascular Function and Hypertension in Mice Deficient in Estrogen Receptor β

    Yan Zhu;Zhao Bian;Ping Lu;Richard H. Karas

  • Estrogen inhibits the vascular injury response in estrogen receptor alpha-deficient mice.

    Mark D. Iafrati;Richard H. Karas;Mark Aronovitz;Sung Kim

  • Cardiac myocytes and fibroblasts contain functional estrogen receptors

    Christian Grohé;Stefan Kahlert;Kerstin Löbbert;Michael Stimpel

  • Estrogen and progestogen use in postmenopausal women: July 2008 position statement of The North American Menopause Society.

    Utian Wh;Archer Df;Bachmann Ga;Gallagher C

  • Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure

    K Mary Tang;Guang-rong Wang;Ping Lu;Richard H Karas

  • Estrogen Receptor-α Mediates the Protective Effects of Estrogen Against Vascular Injury

    Gary Pare;Andrée Krust;Richard H. Karas;Sonia Dupont

  • Estrogen and the blood vessel wall.

    Michael E. Mendelsohn;Richard H. Karas

  • Increased Expression of Estrogen Receptor-β mRNA in Male Blood Vessels After Vascular Injury

    Volkhard Lindner;Sung K. Kim;Richard H. Karas;George G. J. M. Kuiper

  • 17β-Estradiol Reduces Cardiomyocyte Apoptosis In Vivo and In Vitro via Activation of Phospho-Inositide-3 Kinase/Akt Signaling

    Richard D. Patten;Isaac Pourati;Mark J. Aronovitz;Jason Baur

  • Association between estrogen receptor α gene variation and cardiovascular disease

    Amanda M. Shearman;L. Adrienne Cupples;Serkalem Demissie;Inga Peter

  • Peripheral vascular endothelial function testing as a noninvasive indicator of coronary artery disease

    Jeffrey T Kuvin;Ayan R Patel;Kathleen A Sliney;Natesa G Pandian

  • Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor α

    Qing Lu;David C. Pallas;Howard K. Surks;Wendy E. Baur

Frequent Co-Authors

Natesa G. Pandian
Natesa G. Pandian Tufts Medical Center
David A. Kass
David A. Kass Johns Hopkins University School of Medicine
James E. Udelson
James E. Udelson Tufts Medical Center
Michael H. Davidson
Michael H. Davidson University of Chicago
William M. Rand
William M. Rand Tufts University
Martin S. Maron
Martin S. Maron Tufts University
Marvin A. Konstam
Marvin A. Konstam Tufts Medical Center
Roger J. Davis
Roger J. Davis University of Massachusetts Chan Medical School
Christopher H. Schmid
Christopher H. Schmid Brown University

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