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Ulrich Brinkmann

Ulrich Brinkmann

D-Index & Metrics

Biology and Biochemistry

D-Index
74
Citations
22338
World Ranking
5539
National Ranking
109

Overview

Ulrich Brinkmann is affiliated with Roche (Switzerland) and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research spans several specialized areas including molecular biology, oncology, radiology, nuclear medicine, cancer research, and renewable energy, sustainability, and the environment.

Their work has focused on key topics such as monoclonal and polyclonal antibodies research, CAR-T cell therapy research, microRNA in disease regulation, RNA and protein synthesis mechanisms, glycosylation and glycoproteins research, nanofabrication and lithography techniques, and RNA modifications and cancer.

Among recent publications authored or co-authored by Ulrich Brinkmann are:

  • The present and future of bispecific antibodies for cancer therapy, 2024, Nature Reviews Drug Discovery
  • Bispecific antibodies, 2021, Science
  • Format and geometries matter: Structure-based design defines the functionality of bispecific antibodies, 2020, Computational and Structural Biotechnology Journal
  • Diphthamide-deficiency syndrome: a novel human developmental disorder and ribosomopathy, 2020, European Journal of Human Genetics
  • Format chain exchange (FORCE) for high-throughput generation of bispecific antibodies in combinatorial binder-format matrices, 2020, Nature Communications

Frequent co-authors collaborating with Ulrich Brinkmann include Klaus Mayer, Raffael Schaffrath, Koray Ütkür, Steffen Dickopf, and Guy Georges.

Their research has been published multiple times in a range of journals, with repetition in these venues:

  • Cancer Genomics & Proteomics
  • Nature Communications
  • Computational and Structural Biotechnology Journal
  • Genetics in Medicine
  • Biomolecules

Best Publications

  • Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

    S. Hoffmeyer;O. Burk;O. von Richter;H. P. Arnold

  • Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects.

    Ingolf Cascorbi;Thomas Gerloff;Andreas Johne;Christian Meisel

  • Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1.

    Asra Siddiqui;Reinhold Kerb;Michael E. Weale;Ulrich Brinkmann

  • The making of bispecific antibodies

    Ulrich Brinkmann;Roland E. Kontermann

  • A method for increasing the yield of properly folded recombinant fusion proteins: Single-chain immunotoxins from renaturation of bacterial inclusion bodies

    Johannes Buchner;Ira Pastan;Ulrich Brinkmann

  • High-level expression of recombinant genes in Escherichia coli is dependent on the availability of the dnaY gene product.

    Ulrich Brinkmann;Ralf E. Mattes;Ralf E. Mattes;Peter Buckel

  • Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis

    Matthias Schwab;Elke Schaeffeler;Claudia Marx;Martin F. Fromm

  • Modulation of steady-state kinetics of digoxin by haplotypes of the P-glycoprotein MDR1 gene.

    Andreas Johne;Karla Köpke;Thomas Gerloff;Ingrid Mai

  • Frequency of C3435T polymorphism of MDR1 gene in African people

    Elke Schaeffeler;Michel Eichelbaum;Michel Eichelbaum;Ulrich Brinkmann;Anja Penger

  • MDR1 gene polymorphisms and disposition of the P‐glycoprotein substrate fexofenadine

    Siegfried Drescher;Elke Schaeffeler;Monika Hitzl;Ute Hofmann

  • Association of the P-Glycoprotein Transporter MDR1C3435T Polymorphism with the Susceptibility to Renal Epithelial Tumors

    Michael Siegsmund;Ulrich Brinkmann;Elke Scháffeler;Gregor Weirich

  • A recombinant immunotoxin containing a disulfide-stabilized Fv fragment

    U. Brinkmann;Y. Reiter;Sun-Hee Jung;Byungkook Lee

  • Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene.

    Klaus Gellner;Regina Eiselt;Elisabeth Hustert;Hannes Arnold

  • B3(Fv)-PE38KDEL, a single-chain immunotoxin that causes complete regression of a human carcinoma in mice.

    Ulrich Brinkmann;Lee H. Pai;David J. Fitzgerald;Mark Willingham

  • Engineering antibody Fv fragments for cancer detection and therapy: disulfide-stabilized Fv fragments.

    Yoram Reiter;Ulrich Brinkmann;Byungkook Lee;Ira Pastan

  • Progress in overcoming the chain association issue in bispecific heterodimeric IgG antibodies

    Christian Klein;Claudio Sustmann;Markus Thomas;Kay Stubenrauch

  • Natural protein variants of pregnane X receptor with altered transactivation activity toward CYP3A4.

    Elisabeth Hustert;Arne Zibat;Elena Presecan-Siedel;Regina Eiselt

  • Engineering interchain disulfide bonds into conserved framework regions of Fv fragments: improved biochemical characteristics of recombinant immunotoxins containing disulfide-stabilized Fv.

    Yoram Reiter;Ulrich Brinkmann;Keith O. Webber;Sun-Hee Jung

  • Stabilization of the Fv fragments in recombinant immunotoxins by disulfide bonds engineered into conserved framework regions

    Yoram Reiter;Ulrich Brinkmann;Robert J. Kreitman;Sun-Hee Jung

  • ABC drug transporters : hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2

    Reinhold Kerb;Sven Hoffmeyer;Ulrich Brinkmann

Frequent Co-Authors

Ira Pastan
Ira Pastan Center for Cancer Research
Ivar Roots
Ivar Roots Charité - University Medicine Berlin
Christian Klein
Christian Klein Roche (Switzerland)
Michel Eichelbaum
Michel Eichelbaum University of Tübingen
Byungkook Lee
Byungkook Lee National Institutes of Health
Ingolf Cascorbi
Ingolf Cascorbi Kiel University
Matthias Schwab
Matthias Schwab University of Tübingen
Jürgen Brockmöller
Jürgen Brockmöller University of Göttingen
Roland E. Kontermann
Roland E. Kontermann University of Stuttgart
George Vasmatzis
George Vasmatzis Mayo Clinic

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