2011 - ASM Fellow "In recognition of distinguished contributions to the field of materials science and metallography through technical marketing and volunteer service."
His primary areas of study are Pseudomonas exotoxin, Immunotoxin, Molecular biology, Exotoxin and Antibody. His study in Pseudomonas exotoxin is interdisciplinary in nature, drawing from both Cytotoxic T cell, Microbiology and Virology. His Immunotoxin study combines topics in areas such as Cancer research and Immunotherapy.
His Molecular biology research includes themes of Epitope, Epidermal growth factor, Fusion protein and Escherichia coli. His work in Exotoxin addresses issues such as Stereochemistry, which are connected to fields such as Microbial toxins, Polyethylene glycol and Glutathione. David J. FitzGerald works mostly in the field of Antibody, limiting it down to topics relating to Antigen and, in certain cases, Cancer cell, Diphtheria toxin, Cell biology, Cell surface receptor and Internalization.
His main research concerns Pseudomonas exotoxin, Immunotoxin, Molecular biology, Exotoxin and Biochemistry. His Pseudomonas exotoxin research is under the purview of Recombinant DNA. His Immunotoxin study integrates concerns from other disciplines, such as Cancer research and Antigen.
As a part of the same scientific study, he usually deals with the Molecular biology, concentrating on Cytotoxicity and frequently concerns with Pharmacology. The concepts of his Exotoxin study are interwoven with issues in Epitope, In vitro and Mutant. His work on Amino acid, Cleavage, Furin and Protease is typically connected to Elongation factor as part of general Biochemistry study, connecting several disciplines of science.
David J. FitzGerald mainly focuses on Immunotoxin, Cancer research, Pseudomonas exotoxin, Molecular biology and Cancer cell. His research on Immunotoxin concerns the broader Antibody. His Cancer research research includes elements of Recombinant immunotoxin and Pancreatic cancer.
His Pseudomonas exotoxin study incorporates themes from Cell, Antigen, Pharmacology and Furin. David J. FitzGerald has included themes like Epitope, Apoptosis, B cell and Cytotoxicity in his Molecular biology study. His study looks at the relationship between Cancer cell and fields such as Tyrosine kinase, as well as how they intersect with chemical problems.
David J. FitzGerald mainly investigates Immunotoxin, Molecular biology, Pseudomonas exotoxin, Apoptosis and Antibody. His Immunotoxin research incorporates elements of Cytotoxic T cell and Keyhole limpet hemocyanin. As a part of the same scientific family, David J. FitzGerald mostly works in the field of Molecular biology, focusing on Cytotoxicity and, on occasion, Transferrin receptor, Caspase 7 and Caspase 3.
David J. FitzGerald focuses mostly in the field of Pseudomonas exotoxin, narrowing it down to matters related to Furin and, in some cases, Tyrosine kinase, Cancer cell and Cancer research. His work in the fields of Apoptosis, such as Programmed cell death and Unfolded protein response, overlaps with other areas such as BH3 Mimetic ABT-737. His work in Antibody addresses subjects such as Immunotherapy, which are connected to disciplines such as Antigen and Chronic lymphocytic leukemia.
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Immunotoxin Therapy of Cancer
Ira Pastan;Raffit Hassan;David J. FitzGerald;Robert J. Kreitman.
Nature Reviews Cancer (2006)
Efficacy of the Anti-CD22 Recombinant Immunotoxin BL22 in Chemotherapy-Resistant Hairy-Cell Leukemia
Robert J. Kreitman;Wyndham H. Wilson;Karen Bergeron;Miranda Raggio.
The New England Journal of Medicine (2001)
Functional domains of Pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli.
Jaulang Hwang;David J. Fitzgerald;Sankar Adhya;Ira Pastan.
Cell (1987)
A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin
Vijay K. Chaudhary;Gary Queen;Richard P. Junghans;Thomas A. Waldmann.
Nature (1989)
Identification of tandem duplicate regulatory small RNAs in Pseudomonas aeruginosa involved in iron homeostasis
Paula J. Wilderman;Nathaniel A. Sowa;David J. FitzGerald;Peter C. FitzGerald.
Proceedings of the National Academy of Sciences of the United States of America (2004)
Recombinant toxins for cancer treatment.
Ira Pastan;David Fitzgerald.
Science (1991)
Immunotoxin Treatment of Cancer
Ira Pastan;Raffit Hassan;David J. FitzGerald;Robert J. Kreitman.
Annual Review of Medicine (2007)
Anti-CD22–chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia
Waleed Haso;Daniel W. Lee;Nirali N. Shah;Maryalice Stetler-Stevenson.
Blood (2013)
Recombinant toxins as novel therapeutic agents.
Ira Pastan;Vijay Chaudhary;David J. FitzGerald.
Annual Review of Biochemistry (1992)
Phase I Trial of Anti-CD22 Recombinant Immunotoxin Moxetumomab Pasudotox (CAT-8015 or HA22) in Patients With Hairy Cell Leukemia
Robert J. Kreitman;Martin S. Tallman;Tadeusz Robak;Steven Coutre.
Journal of Clinical Oncology (2012)
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