World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
59
Citations
9504
World Ranking
2041
National Ranking
1014

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Amino acid

His main research concerns Molecular biology, Immunotoxin, Pseudomonas exotoxin, Recombinant DNA and Monoclonal antibody. The various areas that he examines in his Molecular biology study include Mesothelin, Transmembrane domain and Functional genomics. His Immunotoxin study deals with the bigger picture of Antibody.

The study incorporates disciplines such as Cytotoxic T cell, Immunogenicity and Virology in addition to Pseudomonas exotoxin. His work carried out in the field of Recombinant DNA brings together such families of science as Protein structure, Disulfide bond and Stereochemistry. His Monoclonal antibody research integrates issues from Cancer cell and Plasma protein binding.

His most cited work include:

  • Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors (274 citations)
  • A recombinant immunotoxin containing a disulfide-stabilized Fv fragment (261 citations)
  • Site-specific chemical modification with polyethylene glycol of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenicity. (238 citations)

What are the main themes of his work throughout his whole career to date?

Byungkook Lee mainly focuses on Molecular biology, Gene, Antibody, Protein structure and Genetics. The concepts of his Molecular biology study are interwoven with issues in Cell culture, Fusion protein, Epitope, Pseudomonas exotoxin and Monoclonal antibody. Pseudomonas exotoxin is a subfield of Recombinant DNA that Byungkook Lee investigates.

His Gene research is multidisciplinary, incorporating elements of Breast cancer and Prostate cancer. Byungkook Lee has researched Antibody in several fields, including Cancer cell, Cell and Antigen. His work deals with themes such as Protein secondary structure, Peptide sequence, Sequence alignment, Crystallography and Protein domain, which intersect with Protein structure.

He most often published in these fields:

  • Molecular biology (30.62%)
  • Gene (21.88%)
  • Antibody (19.38%)

What were the highlights of his more recent work (between 2005-2019)?

  • Molecular biology (30.62%)
  • Genetics (17.50%)
  • Gene (21.88%)

In recent papers he was focusing on the following fields of study:

His primary areas of investigation include Molecular biology, Genetics, Gene, Protein structure and Peptide sequence. His research integrates issues of Epitope, Antibody, Mesothelin and Pseudomonas exotoxin in his study of Molecular biology. Byungkook Lee is interested in Immunotoxin, which is a branch of Antibody.

He has included themes like Recombinant DNA and Antigen in his Immunotoxin study. His Gene research is multidisciplinary, incorporating perspectives in Urokinase receptor and Acetylcholine receptor. His research in the fields of Sequence alignment overlaps with other disciplines such as 14-3-3 protein.

Between 2005 and 2019, his most popular works were:

  • Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors (274 citations)
  • A Binding Domain on Mesothelin for CA125/MUC16 (119 citations)
  • Recombinant immunotoxin engineered for low immunogenicity and antigenicity by identifying and silencing human B-cell epitopes (118 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Amino acid

Byungkook Lee spends much of his time researching Molecular biology, Epitope, Immunotoxin, Virology and Pseudomonas exotoxin. His Molecular biology study combines topics from a wide range of disciplines, such as Mesothelin, Antibody, Monoclonal antibody and Peptide sequence. His Antibody research includes elements of Cell culture, Transfection and Prostate, LNCaP, Prostate cancer.

His Monoclonal antibody study combines topics in areas such as Polyclonal antibodies, Transmembrane domain, Immunofluorescence, Binding site and Topology. His Immunotoxin study integrates concerns from other disciplines, such as Epitope mapping and Immunogenicity. His Glycoprotein research incorporates themes from Peritoneal fluid, Cancer research, Peritoneal Neoplasm and Ovarian tumor.

Best Publications

  • Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors

    Jennifer A A Gubbels;Jennifer Belisle;Masanori Onda;Claudine Rancourt

  • Site-specific chemical modification with polyethylene glycol of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenicity.

    Yasuo Tsutsumi;Masanori Onda;Satoshi Nagata;Byungkook Lee

  • A recombinant immunotoxin containing a disulfide-stabilized Fv fragment

    U. Brinkmann;Y. Reiter;Sun-Hee Jung;Byungkook Lee

  • Engineering antibody Fv fragments for cancer detection and therapy: disulfide-stabilized Fv fragments.

    Yoram Reiter;Ulrich Brinkmann;Byungkook Lee;Ira Pastan

  • The physical origin of the low solubility of nonpolar solutes in water.

    B. Lee

  • Stabilization of the Fv fragments in recombinant immunotoxins by disulfide bonds engineered into conserved framework regions

    Yoram Reiter;Ulrich Brinkmann;Robert J. Kreitman;Sun-Hee Jung

  • MRP8, a new member of ABC transporter superfamily, identified by EST database mining and gene prediction program, is highly expressed in breast cancer.

    Tapan K. Bera;Sanghyuk Lee;Giuliana Salvatore;Byungkook Lee

  • A Two-State Model of Hydrophobic Hydration That Produces Compensating Enthalpy and Entropy Changes

    B. Lee;Giuseppe Graziano

  • Discovery of three genes specifically expressed in human prostate by expressed sequence tag database analysis

    George Vasmatzis;Magnus Essand;Ulrich Brinkmann;Byungkook Lee

  • A Binding Domain on Mesothelin for CA125/MUC16

    Osamu Kaneko;Lucy Gong;Jingli Zhang;Johanna K. Hansen

  • Improved binding and antitumor activity of a recombinant anti-erbB2 immunotoxin by disulfide stabilization of the Fv fragment.

    Y. Reiter;U. Brinkmann;Sun-Hee Jung;Byungkook Lee

  • Recombinant immunotoxin engineered for low immunogenicity and antigenicity by identifying and silencing human B-cell epitopes

    Wenhai Liu;Masanori Onda;Byungkook Lee;Robert J. Kreitman

  • MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer.

    Tapan K. Bera;Carlo Iavarone;Carlo Iavarone;Vasantha Kumar;Sanghyuk Lee

  • Methods of making recombinant disulfide-stabilized polypeptide fragments having binding specificity

    Ira H. Pastan;Byungkook Lee;Sun-Hee Jung;Ulrich Brinkmann

  • Protein structure alignment using environmental profiles.

    Jongsun Jung;Byungkook Lee

  • Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes

    Masanori Onda;Richard Beers;Laiman Xiang;Byungkook Lee

  • Mesothelin, Stereocilin, and Otoancorin are predicted to have superhelical structures with ARM-type repeats

    Bangalore K Sathyanarayana;Yoonsoo Hahn;Yoonsoo Hahn;Manish S Patankar;Ira Pastan

  • Lowering the isoelectric point of the Fv portion of recombinant immunotoxins leads to decreased nonspecific animal toxicity without affecting antitumor activity.

    Masanori Onda;Satoshi Nagata;Yasuo Tsutsumi;James J. Vincent

  • Characterization of the B Cell Epitopes Associated with a Truncated Form of Pseudomonas Exotoxin (PE38) Used to Make Immunotoxins for the Treatment of Cancer Patients

    Masanori Onda;Satoshi Nagata;David J. FitzGerald;Richard Beers

  • Novel genes in the PAGE and GAGE family of tumor antigens found by homology walking in the dbEST database.

    Ulrich Brinkmann;George Vasmatzis;Byungkook Lee;Ira Pastan

Frequent Co-Authors

Ira Pastan
Ira Pastan Center for Cancer Research
George Vasmatzis
George Vasmatzis Mayo Clinic
Ulrich Brinkmann
Ulrich Brinkmann Roche (Switzerland)
Robert J. Kreitman
Robert J. Kreitman National Cancer Institute
David J. FitzGerald
David J. FitzGerald MRC Laboratory of Molecular Biology
Itai Benhar
Itai Benhar Tel Aviv University
Eduardo A. Padlan
Eduardo A. Padlan National Institutes of Health
Peter J. Munson
Peter J. Munson Center for Information Technology
Mitchell Ho
Mitchell Ho Center for Cancer Research
Robert L. Strausberg
Robert L. Strausberg Ludwig Cancer Research

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