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Paul J. Carter

Paul J. Carter

D-Index & Metrics

Biology and Biochemistry

D-Index
72
Citations
33595
World Ranking
6118
National Ranking
2873

Overview

Paul J. Carter is affiliated with Genentech in the United States and has a research profile focused primarily on medicine and biochemistry, genetics, and molecular biology. Their work spans multiple subfields including radiology, nuclear medicine and imaging, molecular biology, oncology, immunology, and spectroscopy.

The scientist's main areas of study and research topics include monoclonal and polyclonal antibodies, protein purification and stability, CAR-T cell therapy, biosimilars and bioanalytical methods, glycosylation and glycoproteins, immune cell function and interaction, and T-cell and B-cell immunology.

Frequent coauthors in their research include Christoph Spiess, Patrick Wu, Andrew C. Chan, Gregory D. Martyn, and Saeed Izadi. These collaborations appear in various research outputs contributing to a breadth of topics within antibody therapeutics and immunology.

Paul J. Carter has published research in several scientific venues, with notable appearances in:

  • mAbs
  • Nature Reviews Immunology
  • Cell
  • Trends in Immunology
  • Nature Reviews Drug Discovery

Recent publications demonstrate their involvement in antibody-related research and immunogenicity assessments with selected papers including:

  • Designing antibodies as therapeutics, 2022, Cell
  • Immunogenicity risk assessment and mitigation for engineered antibody and protein therapeutics, 2024, Nature Reviews Drug Discovery

Other publications relevant to antibody biophysics and safety assessment are:

  • Variable domain mutational analysis to probe the molecular mechanisms of high viscosity of an IgG 1 antibody, 2024, mAbs
  • Nonclinical immunogenicity risk assessment for knobs-into-holes bispecific IgG 1 antibodies, 2024, mAbs

Paul J. Carter's research contributions are situated at the intersection of antibody therapeutics and immune system interactions, with an emphasis on both biophysical properties and immunogenicity risk assessments. Their published work reflects ongoing investigations into improving the efficacy and safety profiles of antibody-based treatments.

Best Publications

  • Humanization of an anti-p185HER2 antibody for human cancer therapy.

    P. Carter;L. Presta;C. M. Gorman;J. B. B. Ridgway

  • Method for making humanized antibodies

    Paul J. Carter;Leonard G. Presta

  • Potent antibody therapeutics by design

    Paul J. Carter

  • Humanized antibodies and methods for making them

    Paul J. Carter;Leonard G. Presta

  • Hydrogen bonding and biological specificity analysed by protein engineering

    Alan R. Fersht;Jian-Ping Shi;Jack Knill-Jones;Denise M. Lowe

  • Improving the efficacy of antibody-based cancer therapies.

    Paul Carter

  • Therapeutic antibodies for autoimmunity and inflammation

    Andrew C. Chan;Paul J. Carter

  • Expression, in colon bacillus, of antibody fragment having at least cysteine present as free thiol, and use for production of bifunctional f(ab')2 antibody

    Paul J Carter;カーター,ポール・ジェイ

  • ‘Knobs-into-holes’ engineering of antibody CH3 domains for heavy chain heterodimerization

    John B.B. Ridgway;Leonard G. Presta;Paul Carter

  • Method for making multispecific antibodies having heteromultimeric and common components

    W. Robert Arathoon;Paul J. Carter;Anne M. Merchant;Leonard G. Presta

  • Dissecting the catalytic triad of a serine protease

    Paul Carter;James A. Wells

  • Improved oligonudeotide site-directed rautagenesis using M13 vectors

    Paul Carter;Hugues Bedouelle;Greg Winter

  • An efficient route to human bispecific IgG

    A. M. Merchant;Zhenping Zhu;Zhenping Zhu;J. Q. Yuan;A. Goddard

  • The use of double mutants to detect structural changes in the active site of the tyrosyl-tRNA synthetase (Bacillus stearothermophilus)

    Paul J. Carter;Greg Winter;Anthony J. Wilkinson;Alan R. Fersht

  • Next generation antibody drugs: pursuit of the 'high-hanging fruit'.

    Paul J. Carter;Greg A. Lazar

  • Differential responses of human tumor cell lines to anti-p185HER2 monoclonal antibodies.

    G D Lewis;I Figari;B Fendly;W L Wong

  • Alternative molecular formats and therapeutic applications for bispecific antibodies.

    Christoph Spiess;Qianting Zhai;Paul J. Carter

  • STERICALLY STABILIZED ANTI-HER2 IMMUNOLIPOSOMES : DESIGN AND TARGETING TO HUMAN BREAST CANCER CELLS IN VITRO

    Dmitri Kirpotin;John W. Park;Keelung Hong;Samuel Zalipsky

  • High level Escherichia coli expression and production of a bivalent humanized antibody fragment.

    Carter P;Kelley Rf;Rodrigues Ml;Snedecor B

  • Introduction to current and future protein therapeutics: A protein engineering perspective

    Paul J. Carter

Frequent Co-Authors

Greg Winter
Greg Winter University of Cambridge
Nan Chiang
Nan Chiang Brigham and Women's Hospital
Anthony J. Wilkinson
Anthony J. Wilkinson University of York
James A. Wells
James A. Wells University of California, San Francisco
Hans-Peter Gerber
Hans-Peter Gerber Seattle Genetics (United States)
Mary M.Y. Waye
Mary M.Y. Waye Chinese University of Hong Kong

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