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Molecular Biology

D-Index
46
Citations
7990
World Ranking
2808
National Ranking
1348

Overview

Sarah J. Wheelan is affiliated with Johns Hopkins University School of Medicine in the United States. Their research spans across multiple disciplines within biochemistry, genetics, and molecular biology, with significant contributions in medicine. The main fields of study include biochemistry, genetics, molecular biology, and medicine, while the subfields focus on molecular biology, oncology, immunology, cancer research, and epidemiology.

The scientist's work covers a variety of topics reflecting contemporary techniques and applications in molecular and cancer biology. These topics include:

  • CRISPR and Genetic Engineering
  • Cancer Genomics and Diagnostics
  • Single-cell and Spatial Transcriptomics
  • Gene Expression and Cancer Classification
  • Molecular Biology Techniques and Applications
  • Hepatitis C Virus Research
  • Advanced Biosensing and Bioanalysis Techniques

Sarah J. Wheelan has contributed research to several peer-reviewed journals. Frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Nature
  • Molecular Microbiology
  • The Prostate

Their recent work includes papers such as:

  • "Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers," 2021, published in Nature
  • "A conserved intratumoral regulatory T cell signature identifies 4-1BB as a pan-cancer target," 2020, published in Journal of Clinical Investigation
  • "Inverting the model of genomics data sharing with the NHGRI Genomic Data Science Analysis, Visualization, and Informatics Lab-space," 2022, published in Cell Genomics
  • "De novo genome assembly of Candida glabrata reveals cell wall protein complement and structure of dispersed tandem repeat arrays," 2020, published in Molecular Microbiology
  • "Cell wall protein variation, break-induced replication, and subtelomere dynamics in Candida glabrata," 2021, published in Molecular Microbiology

The scientist has collaborated extensively with colleagues, including frequent co-authors such as Alyza Skaist, Srinivasan Yegnasubramanian, Ajay Vaghasia, Jennifer Meyers, and William G. Nelson.

Best Publications

  • Spidey: a tool for mRNA-to-genomic alignments.

    Sarah J. Wheelan;Deanna M. Church;James M. Ostell

  • Nuclear miRNA Regulates the Mitochondrial Genome in the Heart

    Samarjit Das;Marcella Ferlito;Oliver A. Kent;Karen Fox-Talbot

  • Gibbon genome and the fast karyotype evolution of small apes

    Lucia Carbone;R. Alan Harris;Sante Gnerre;Krishna R. Veeramah;Krishna R. Veeramah

  • Directed targeting of chromatin to the nuclear lamina is mediated by chromatin state and A-type lamins

    Jennifer C. Harr;Teresa Romeo Luperchio;Xianrong Wong;Erez Cohen

  • Extensive somatic L1 retrotransposition in colorectal tumors

    Szilvia Solyom;Adam D. Ewing;Eric P. Rahrmann;Tara T. Doucet

  • Mobile Interspersed Repeats Are Major Structural Variants in the Human Genome

    Cheng Ran Lisa Huang;Anna M. Schneider;Yunqi Lu;Tejasvi Niranjan

  • piggyBac transposase tools for genome engineering

    Xianghong Li;Erin R. Burnight;Ashley L. Cooney;Nirav Malani

  • Domain size distributions can predict domain boundaries

    Sarah J. Wheelan;Aron Marchler-Bauer;Stephen H. Bryant

  • Genome-wide consequences of deleting any single gene

    Xinchen Teng;Margaret Dayhoff-Brannigan;Wen Chih Cheng;Catherine E. Gilbert

  • Cellular resolution maps of X-chromosome inactivation: implications for neural development, function, and disease

    Hao Wu;Junjie Luo;Huimin Yu;Amir Rattner

  • GeneDesign: Rapid, automated design of multikilobase synthetic genes

    Sarah M. Richardson;Sarah J. Wheelan;Robert M. Yarrington;Jef D. Boeke

  • Transcriptome-Wide Binding Sites for Components of the Saccharomyces cerevisiae Non-Poly(A) Termination Pathway: Nrd1, Nab3, and Sen1

    Tyler J. Creamer;Miranda M. Darby;Nuttara Jamonnak;Paul Schaughency

  • Clinical Validation of KRAS, BRAF, and EGFR Mutation Detection Using Next-Generation Sequencing

    Ming Tseh Lin;Stacy L. Mosier;Michele Thiess;Katie F. Beierl

  • Sequence and Comparative Analysis of the Mouse 1-Megabase Region Orthologous to the Human 11p15 Imprinted Domain

    Patrick Onyango;Webb Miller;Jessica Lehoczky;Cheuk T. Leung

  • Gene-breaking: a new paradigm for human retrotransposon-mediated gene evolution.

    Sarah J. Wheelan;Yasunori Aizawa;Jeffrey S. Han;Jef D. Boeke

  • Active retrotransposition by a synthetic L1 element in mice.

    Wenfeng An;Jeffrey S. Han;Jeffrey S. Han;Sarah J. Wheelan;Edward S. Davis

  • Sequence variations in the public human genome data reflect a bottlenecked population history

    Gabor Marth;Greg Schuler;Raymond Yeh;Ruth Davenport

  • DNA transposon Hermes inserts into DNA in nucleosome-free regions in vivo

    Sunil Gangadharan;Loris Mularoni;Jennifer Fain-Thornton;Jennifer Fain-Thornton;Sarah J. Wheelan

  • Yeast Nrd1, Nab3, and Sen1 transcriptome-wide binding maps suggest multiple roles in post-transcriptional RNA processing

    Nuttara Jamonnak;Tyler J. Creamer;Miranda M. Darby;Paul Schaughency

  • ATM Kinase Is Required for Telomere Elongation in Mouse and Human Cells

    Stella Suyong Lee;Craig Bohrson;Alexandra Mims Pike;Sarah Jo Wheelan

Frequent Co-Authors

Jef D. Boeke
Jef D. Boeke New York University
Srinivasan Yegnasubramanian
Srinivasan Yegnasubramanian Johns Hopkins University School of Medicine
Joseph A. Califano
Joseph A. Califano University of California, San Diego
James R. Eshleman
James R. Eshleman Johns Hopkins University School of Medicine
Kenneth W. Kinzler
Kenneth W. Kinzler Johns Hopkins University
Bert Vogelstein
Bert Vogelstein Johns Hopkins University
Ludmila Danilova
Ludmila Danilova Johns Hopkins University
William H. Westra
William H. Westra Icahn School of Medicine at Mount Sinai
Alan K. Meeker
Alan K. Meeker Johns Hopkins University School of Medicine
David L. Thomas
David L. Thomas Johns Hopkins University

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