World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
76
Citations
56311
World Ranking
1127
National Ranking
583

Overview

James R. Eshleman is affiliated with the Johns Hopkins University School of Medicine in the United States. Their research spans multiple areas within medicine and biochemistry, genetics, and molecular biology. A significant portion of their work focuses on cancer research, oncology, molecular biology, pulmonary and respiratory medicine, and pathology and forensic medicine.

The scientist's primary topics of research cover cancer genomics and diagnostics, pancreatic and hepatic oncology research, genetic factors in colorectal cancer, CRISPR and genetic engineering, cancer cells and metastasis, renal cell carcinoma treatment, and advanced biosensing and bioanalysis techniques.

Recent publications by James R. Eshleman include the following papers:

  • Patient-derived Organoid Pharmacotyping is a Clinically Tractable Strategy for Precision Medicine in Pancreatic Cancer, 2020, Annals of Surgery
  • Nivolumab plus ipilimumab, with or without enzalutamide, in AR-V7-expressing metastatic castration-resistant prostate cancer: A phase-2 nonrandomized clinical trial, 2021, The Prostate
  • Tumor Frameshift Mutation Proportion Predicts Response to Immunotherapy in Mismatch Repair-Deficient Prostate Cancer, 2020, The Oncologist
  • DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association, 2021, Communications Biology
  • Molecular characterization of organoids derived from pancreatic intraductal papillary mucinous neoplasms, 2020, The Journal of Pathology

The scientist frequently collaborates with several co-authors, including Ralph H. Hruban, Ming-Tseh Lin, Nicholas J. Roberts, Aparna Pallavajjala, and Kirsten Bowland. These collaborations have contributed to a substantial number of joint publications.

James R. Eshleman's work is often published in specialized venues that include:

  • Cancer Research
  • Journal of Molecular Diagnostics
  • American Journal of Clinical Pathology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Modern Pathology

This combination of research fields, topics, and publication venues highlights the focus on translational and diagnostic aspects of oncology and molecular biology, particularly emphasizing pancreatic and prostate cancers. Their scientific contributions integrate molecular characterization, immunotherapy response prediction, and precision medicine approaches.

Best Publications

  • PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

    Dung T. Le;Jennifer N. Uram;Hao Wang;Bjarne R. Bartlett

  • Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

    Dung T. Le;Dung T. Le;Jennifer N. Durham;Jennifer N. Durham;Kellie N. Smith;Hao Wang

  • Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

    Siân Jones;Xiaosong Zhang;D. Williams Parsons;D. Williams Parsons;Jimmy Cheng Ho Lin

  • A National Cancer Institute Workshop on Microsatellite Instability for Cancer Detection and Familial Predisposition: Development of International Criteria for the Determination of Microsatellite Instability in Colorectal Cancer

    C. Richard Boland;Stephen N. Thibodeau;Stanley R. Hamilton;David Sidransky

  • Genomic analyses identify molecular subtypes of pancreatic cancer

    Bailey P;Chang Dk;Nones K;Nones K;Johns Al

  • Whole genomes redefine the mutational landscape of pancreatic cancer.

    Nicola Waddell;Marina Pajic;Ann Marie Patch;David K. Chang

  • Distant metastasis occurs late during the genetic evolution of pancreatic cancer

    Shinichi Yachida;Siân Jones;Ivana Bozic;Tibor Antal;Tibor Antal

  • Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

    Andrew V. Biankin;Andrew V. Biankin;Andrew V. Biankin;Nicola Waddell;Karin S. Kassahn;Marie Claude Gingras

  • International network of cancer genome projects

    Thomas J. Hudson;Thomas J. Hudson;Warwick Anderson;Axel Aretz;Anna D. Barker

  • Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

    David M. Berman;Sunil S. Karhadkar;Anirban Maitra;Rocio Montes De Oca

  • Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer.

    Vinod P. Balachandran;Marta Łuksza;Julia N. Zhao;Vladimir Makarov

  • DPC4 Gene Status of the Primary Carcinoma Correlates With Patterns of Failure in Patients With Pancreatic Cancer

    Christine A. Iacobuzio-Donahue;Baojin Fu;Shinichi Yachida;Mingde Luo

  • Exomic Sequencing Identifies PALB2 as a Pancreatic Cancer Susceptibility Gene

    Siân Jones;Siân Jones;Ralph H. Hruban;Mihoko Kamiyama;Michael Borges

  • Microsatellite Instability as a Biomarker for PD-1 Blockade

    Jonathan C. Dudley;Ming Tseh Lin;Dung T. Le;James R. Eshleman

  • Recurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development

    Jian Wu;Hanno Matthaei;Anirban Maitra;Marco Dal Molin

  • Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways

    Jian Wu;Yuchen Jiao;Marco Dal Molin;Anirban Maitra

  • Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays.

    Christine A. Iacobuzio-Donahue;Anirban Maitra;Mari Olsen;Anson W. Lowe

  • ATM Mutations in Patients with Hereditary Pancreatic Cancer

    Nicholas J. Roberts;Yuchen Jiao;Jun Yu;Levy Kopelovich

  • Comparison of Sanger Sequencing, Pyrosequencing, and Melting Curve Analysis for the Detection of KRAS Mutations: Diagnostic and Clinical Implications

    Athanasios C. Tsiatis;Alexis Norris-Kirby;Roy G. Rich;Michael J. Hafez

  • PD-1 blockade in tumors with mismatch repair deficiency.

    Dung T. Le;Jennifer N. Uram;Hao Wang;Bjarne Bartlett

Frequent Co-Authors

Ralph H. Hruban
Ralph H. Hruban Johns Hopkins University School of Medicine
Michael Goggins
Michael Goggins Johns Hopkins University
Anirban Maitra
Anirban Maitra The University of Texas MD Anderson Cancer Center
Bert Vogelstein
Bert Vogelstein Johns Hopkins University
Alison P. Klein
Alison P. Klein Johns Hopkins University
Kenneth W. Kinzler
Kenneth W. Kinzler Johns Hopkins University
Christopher L. Wolfgang
Christopher L. Wolfgang New York University
Nickolas Papadopoulos
Nickolas Papadopoulos Johns Hopkins University School of Medicine
Marcia I. Canto
Marcia I. Canto Johns Hopkins University
Richard D. Schulick
Richard D. Schulick University of Colorado Anschutz Medical Campus

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring Molecular Biology can open doors to a variety of related online degrees and career options in the life and behavioral sciences. Many students who start with molecular biology are also interested in human behavior, mental health, or work at the intersection of science and the community.

Those curious about rapidly advancing their education may consider accelerated psychology masters programs to deepen their understanding of psychological processes and research methods. For individuals interested in direct client support and mental health services, earning a masters degree in counseling online provides a flexible route to certification.

If integrating biology with legal or investigative work fascinates you, consider exploring what can i do with a forensic psychology degree for insights into crime scene analysis, criminal profiling, and the justice system. Additionally, those drawn to child development may pursue a masters in child psychology to work in schools, clinics, or social services.

Each of these pathways complements a background in molecular biology and broadens your career prospects across health, research, education, and public service sectors.

Best Scientists Citing James R. Eshleman

Trending Scientists

Recently Published Articles