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Medicine

D-Index
114
Citations
116777
World Ranking
4612
National Ranking
2505

Overview

Nickolas Papadopoulos is affiliated with Johns Hopkins University School of Medicine in the United States. Their research spans various areas within medicine, biochemistry, genetics, and molecular biology, focusing significantly on cancer research and oncology. Their work also covers molecular biology, pathology and forensic medicine, as well as radiology, nuclear medicine, and imaging.

The scientist's main topics of study include:

  • Cancer Genomics and Diagnostics
  • Genetic factors in colorectal cancer
  • CAR-T cell therapy research
  • Pancreatic and Hepatic Oncology Research
  • Monoclonal and Polyclonal Antibodies Research
  • Single-cell and spatial transcriptomics
  • Radiomics and Machine Learning in Medical Imaging

Among recent papers authored or co-authored by Nickolas Papadopoulos are:

  • Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention, 2020, Science
  • Targeting a neoantigen derived from a common TP53 mutation, 2021, Science
  • The Liquid Biopsy Consortium: Challenges and opportunities for early cancer detection and monitoring, 2023, Cell Reports Medicine
  • Bispecific antibodies targeting mutant RAS neoantigens, 2021, Science Immunology
  • The Origin of Highly Elevated Cell-Free DNA in Healthy Individuals and Patients with Pancreatic, Colorectal, Lung, or Ovarian Cancer, 2023, Cancer Discovery

Frequent co-authors include Kenneth W. Kinzler, Bert Vogelstein, Chetan Bettegowda, Shibin Zhou, and Maria Popoli. These collaborations reflect sustained partnerships contributing extensively to their joint research outputs.

Papadopoulos has published predominantly in venues such as bioRxiv (Cold Spring Harbor Laboratory), Journal of Clinical Oncology, Cancer Research, Nature Communications, and Proceedings of the National Academy of Sciences. These journals are consistent platforms supporting dissemination of research in oncology, cancer biology, and related medical sciences.

The breadth of publications indicates a strong engagement with translational cancer research, addressing both diagnostic and therapeutic approaches. This research encompasses studies on biomarkers like cell-free DNA, neoantigens relevant to immunotherapies, and advances in liquid biopsy techniques.

Best Publications

  • PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

    Dung T. Le;Jennifer N. Uram;Hao Wang;Bjarne R. Bartlett

  • Cancer Genome Landscapes

    Bert Vogelstein;Nickolas Papadopoulos;Victor E. Velculescu;Shibin Zhou

  • Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

    Dung T. Le;Dung T. Le;Jennifer N. Durham;Jennifer N. Durham;Kellie N. Smith;Hao Wang

  • An Integrated Genomic Analysis of Human Glioblastoma Multiforme

    D. Williams Parsons;Siân Jones;Xiaosong Zhang;Jimmy Cheng-Ho Lin

  • Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

    Siân Jones;Xiaosong Zhang;D. Williams Parsons;D. Williams Parsons;Jimmy Cheng Ho Lin

  • Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

    Chetan Bettegowda;Chetan Bettegowda;Mark Sausen;Rebecca J. Leary;Isaac Kinde

  • Consensus coding sequences of human breast and colorectal cancers

    Tobias Sjoblom;Sian Jones;D. Williams Parsons;Laura D. Wood

  • Genomic landscapes of human breast and colorectal cancers

    Laura D. Wood;Williams D. Parsons;Sian Jones;Jimmy Lin

  • Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

    Fredrick S. Leach;Nicholas C. Nicolaides;Nickolas Papadopoulos;Bo Liu

  • Detection and localization of surgically resectable cancers with a multi-analyte blood test

    Joshua D. Cohen;Lu Li;Yuxuan Wang;Christopher Thoburn

  • Mutation of a mutL homolog in hereditary colon cancer

    Nickolas Papadopoulos;Nicholas C. Nicolaides;Ying Fei Wei;Steven M. Ruben

  • Mutations of two PMS homologues in hereditary nonpolyposis colon cancer.

    Nicholas C. Nicolaides;Nickolas Papadopoulos;Bo Liu;Ying Fei Weit

  • Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1

    Nishant Agrawal;Mitchell J. Frederick;Curtis R. Pickering;Chetan Bettegowda

  • Daxx/atrx, men1, and mtor pathway genes are frequently altered in pancreatic neuroendocrine tumors

    Yuchen Jiao;Chanjuan Shi;Barish H. Edil;Roeland F. De Wilde

  • The Vigorous Immune Microenvironment of Microsatellite Instable Colon Cancer Is Balanced by Multiple Counter-Inhibitory Checkpoints

    Nicolas J. Llosa;Michael Cruise;Ada Tam;Elizabeth C. Wicks

  • TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

    Patrick J. Killela;Zachary J. Reitman;Yuchen Jiao;Chetan Bettegowda

  • Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma

    Siân Jones;Tian Li Wang;Ie Ming Shih;Tsui Lien Mao

  • The Molecular Basis of Turcot's Syndrome

    Stanley R. Hamilton;bo Liu;Ramon E. Parsons;Nickolas Papadopoulos

  • Hypermutability and mismatch repair deficiency in RER+ tumor cells

    Ramon Parsons;Guo Min Li;Matthew J. Longley;Woei horng Fang;Woei horng Fang

  • Abstract 5606: Detection of circulating tumor DNA in early and late stage human malignancies

    Chetan Bettegowda;Mark Sausen;Rebecca Leary;Isaac Kinde

Frequent Co-Authors

Bert Vogelstein
Bert Vogelstein Johns Hopkins University
Kenneth W. Kinzler
Kenneth W. Kinzler Johns Hopkins University
Luis A. Diaz
Luis A. Diaz Memorial Sloan Kettering Cancer Center
Ralph H. Hruban
Ralph H. Hruban Johns Hopkins University School of Medicine
Victor E. Velculescu
Victor E. Velculescu Johns Hopkins University School of Medicine
Rachel Karchin
Rachel Karchin Johns Hopkins University
George J. Netto
George J. Netto University of Alabama at Birmingham
Laura D. Wood
Laura D. Wood Johns Hopkins University School of Medicine
Alison P. Klein
Alison P. Klein Johns Hopkins University
Tian Li Wang
Tian Li Wang Johns Hopkins University

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