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Molecular Biology

D-Index
54
Citations
16590
World Ranking
2303
National Ranking
1135

Overview

John P. Manis is affiliated with Boston Children's Hospital in the United States and has a primary research focus within the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans several subfields, notably Molecular Biology, Genetics, Immunology, Hematology, and Pediatrics, Perinatology and Child Health.

The main topics covered in Manis's research include:

  • Hemoglobinopathies and Related Disorders
  • CRISPR and Genetic Engineering
  • Prenatal Screening and Diagnostics
  • Virus-based gene therapy research
  • Erythrocyte Function and Pathophysiology
  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology

Manis has contributed frequently to several scientific journals. The most common publication venues are:

  • Blood
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Blood Advances
  • Transfusion
  • New England Journal of Medicine

Frequent collaborators include:

  • Christian Brendel
  • David A. Williams
  • Daniel E. Bauer
  • David G. Justus
  • Myriam Armant

Some recent papers authored or co-authored by John P. Manis are:

  • "Post-Transcriptional Genetic Silencing of BCL11A to Treat Sickle Cell Disease," 2020, published in New England Journal of Medicine
  • "Therapeutic base editing of human hematopoietic stem cells," 2020, published in Nature Medicine
  • "Preclinical Evaluation of a Novel Lentiviral Vector Driving Lineage-Specific BCL11A Knockdown for Sickle Cell Gene Therapy," 2020, published in Molecular Therapy - Methods & Clinical Development
  • "Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion," 2021, published in Science Translational Medicine
  • "Antibody-mediated antigen loss switches augmented immunity to antibody-mediated immunosuppression," 2023, published in Blood

Best Publications

  • Plasma cell differentiation requires the transcription factor XBP-1

    Andreas M. Reimold;Neal N. Iwakoshi;John Manis;Prashanth Vallabhajosyula

  • Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

    Hwei-Ling Cheng;Raul Mostoslavsky;Shin'ichi Saito;John P. Manis

  • MDC1 Maintains Genomic Stability by Participating in the Amplification of ATM-Dependent DNA Damage Signals

    Zhenkun Lou;Katherine Minter-Dykhouse;Sonia Franco;Monica Gostissa

  • Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development

    Yijie Gao;David O. Ferguson;David O. Ferguson;Wei Xie;John P. Manis

  • IgH class switching and translocations use a robust non-classical end-joining pathway

    Catherine T. Yan;Cristian Boboila;Ellen Kris Souza;Sonia Franco

  • Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors.

    Craig H. Bassing;Heikyung Suh;David O. Ferguson;David O. Ferguson;Katrin F. Chua

  • Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations.

    Chengming Zhu;Kevin D. Mills;David O. Ferguson;Charles Lee

  • Mechanism and control of class-switch recombination

    John P Manis;Ming Tian;Frederick W Alt

  • DNA Ligase IV Deficiency in Mice Leads to Defective Neurogenesis and Embryonic Lethality via the p53 Pathway

    Karen M. Frank;Norman E. Sharpless;Yijie Gao;Jo Ann M. Sekiguchi

  • Growth Retardation and Leaky SCID Phenotype of Ku70-Deficient Mice

    Yansong Gu;Katherine J. Seidl;Gary A. Rathbun;Chengming Zhu

  • Highly efficient therapeutic gene editing of human hematopoietic stem cells.

    Yuxuan Wu;Jing Zeng;Jing Zeng;Benjamin P. Roscoe;Pengpeng Liu

  • Post-Transcriptional Genetic Silencing of BCL11A to Treat Sickle Cell Disease

    Erica B. Esrick;Leslie E. Lehmann;Alessandra Biffi;Maureen Achebe

  • 53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination

    John P Manis;Julio C Morales;Zhenfang Xia;Jeffery L Kutok

  • Ku70 Is Required for Late B Cell Development and Immunoglobulin Heavy Chain Class Switching

    John P. Manis;Yansong Gu;Rusty Lansford;Eiichiro Sonoda

  • Leaky Scid Phenotype Associated with Defective V(D)J Coding End Processing in Artemis-Deficient Mice

    Sean Rooney;Jo Ann Sekiguchi;Chengming Zhu;Hwei Ling Cheng

  • The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation

    Uttiya Basu;Jayanta Chaudhuri;Jayanta Chaudhuri;Craig Alpert;Shilpee Dutt

  • Evolution of the immunoglobulin heavy chain class switch recombination mechanism.

    Jayanta Chaudhuri;Uttiya Basu;Uttiya Basu;Ali Zarrin;Ali Zarrin;Catherine Yan;Catherine Yan

  • H2AX Prevents DNA Breaks from Progressing to Chromosome Breaks and Translocations

    Sonia Franco;Monica Gostissa;Shan Zha;David B. Lombard

  • S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase.

    Robert Wuerffel;Lili Wang;Fernando Grigera;John Manis

  • Deficiencies of GM-CSF and Interferon γ Link Inflammation and Cancer

    Thomas Enzler;Silke Gillessen;John P. Manis;David Ferguson

Frequent Co-Authors

Frederick W. Alt
Frederick W. Alt Boston Children's Hospital
Raif S. Geha
Raif S. Geha Boston Children's Hospital
Luigi D. Notarangelo
Luigi D. Notarangelo National Institutes of Health
David A. Williams
David A. Williams Boston Children's Hospital
Silvia Giliani
Silvia Giliani University of Brescia
Waleed Al-Herz
Waleed Al-Herz Kuwait University
Andrew R. Gennery
Andrew R. Gennery Newcastle University
Laurie Davidson
Laurie Davidson Howard Hughes Medical Institute
Jo Ann Sekiguchi
Jo Ann Sekiguchi University of Michigan–Ann Arbor
Klaus Rajewsky
Klaus Rajewsky Max Delbrück Center for Molecular Medicine

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