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Dennis E. Hruby

D-Index & Metrics

Biology and Biochemistry

D-Index
63
Citations
10895
World Ranking
10461
National Ranking
4541

Dennis E. Hruby publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Dennis E. Hruby sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 238 publications — 64th percentile

64% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Dennis E. Hruby D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Dennis E. Hruby sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 63 D-Index — 49th percentile

49% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Dennis E. Hruby is affiliated with Siga Technologies in the United States and has contributed extensively to research in immunology, microbiology, biochemistry, genetics, molecular biology, and medicine. Their work primarily focuses on viral infections, especially poxvirus research and outbreaks. Hruby's research spans related fields such as virology, epidemiology, molecular biology, genetics, and plant science, reflecting a broad interest in both human and plant viruses.

The scientist's main research topics include:

  • Poxvirus research and outbreaks
  • Herpesvirus infections and treatments
  • Bacillus and Francisella bacterial research
  • Virus-based gene therapy research
  • Plant virus research studies
  • Immunotherapy and immune responses

Hruby has authored multiple papers, with several notable recent publications that highlight specific viral treatments and regulatory advances. Key papers include:

  • "An overview of tecovirimat for smallpox treatment and expanded anti-orthopoxvirus applications," 2020, Expert Review of Anti-infective Therapy
  • "Tecovirimat is effective against human monkeypox virus in vitro at nanomolar concentrations," 2022, Nature Microbiology
  • "Tecovirimat for Clade I MPXV Infection in the Democratic Republic of Congo," 2025, New England Journal of Medicine
  • "Overview of the regulatory approval of tecovirimat intravenous formulation for treatment of smallpox: potential impact on smallpox outbreak response capabilities, and future tecovirimat development potential," 2023, Expert Review of Anti-infective Therapy
  • "Tecovirimat is highly efficient on the Monkeypox virus lineage responsible for the international 2022 outbreak," 2022, bioRxiv (Cold Spring Harbor Laboratory)

Frequent co-authors in Hruby's publications include:

  • Douglas W. Grosenbach
  • Andrew T. Russo
  • Kady M. Honeychurch
  • Paul G. Long
  • Gaelle Frénois-Veyrat

Publications have appeared predominantly in venues such as:

  • Expert Review of Anti-infective Therapy
  • Nature Microbiology
  • New England Journal of Medicine
  • bioRxiv (Cold Spring Harbor Laboratory)
  • PLoS Biology

Hruby's research emphasis illustrates a consistent focus on the development and evaluation of antiviral agents, with particular attention to tecovirimat as a treatment for orthopoxvirus infections including smallpox and monkeypox. Their work also addresses regulatory frameworks and outbreak response capabilities related to antiviral therapeutics.

Best Publications

  • An Orally Bioavailable Antipoxvirus Compound (ST-246) Inhibits Extracellular Virus Formation and Protects Mice from Lethal Orthopoxvirus Challenge

    Guang Yang;Daniel C. Pevear;Marc H. Davies;Marc S. Collett

  • Severe Eczema Vaccinatum in a Household Contact of a Smallpox Vaccinee

    Surabhi Vora;Inger Damon;Vincent Fulginiti;Vincent Fulginiti;Stephen G. Weber

  • Yeast KEX2 endopeptidase correctly cleaves a neuroendocrine prohormone in mammalian cells

    Gary Thomas;Barbara A. Thorne;Laurel Thomas;Richard G. Allen

  • Nonhuman Primates Are Protected from Smallpox Virus or Monkeypox Virus Challenges by the Antiviral Drug ST-246

    John Huggins;Arthur Goff;Lisa Hensley;Eric Mucker

  • Neomycin resistance as a dominant selectable marker for selection and isolation of vaccinia virus recombinants.

    Christine A. Franke;Charles M. Rice;James H. Strauss;Dennis E. Hruby

  • Processing and secretion of nerve growth factor: expression in mammalian cells with a vaccinia virus vector.

    R H Edwards;M J Selby;W C Mobley;S L Weinrich

  • Inactivation of the srtA Gene in Streptococcus gordonii Inhibits Cell Wall Anchoring of Surface Proteins and Decreases In Vitro and In Vivo Adhesion

    Tové C. Bolken;Christine A. Franke;Kevin F. Jones;Gloria O. Zeller

  • Chlamydia psittaci IncA is phosphorylated by the host cell and is exposed on the cytoplasmic face of the developing inclusion

    D. D. Rockey;D. Grosenbach;D. E. Hruby;M. G. Peacock

  • Expression of Sindbis virus structural proteins via recombinant vaccinia virus: synthesis, processing, and incorporation into mature Sindbis virions.

    Charles M. Rice;Christine A. Franke;James H. Strauss;Dennis E. Hruby

  • Pox proteomics: mass spectrometry analysis and identification of Vaccinia virion proteins

    Jennifer D Yoder;Tsefang S Chen;Cliff R Gagnier;Srilakshmi Vemulapalli

  • Insertional inactivation of the large subunit of ribonucleotide reductase encoded by vaccinia virus is associated with reduced virulence in vivo

    S. J. Child;G. J. Palumbo;R. M. L. Buller;D. E. Hruby

  • Conditional lethal expression of the vaccinia virus L1R myristylated protein reveals a role in virion assembly.

    M P Ravanello;D E Hruby

  • Progressive Vaccinia: Case Description and Laboratory-Guided Therapy With Vaccinia Immune Globulin, ST-246, and CMX001

    Edith R. Lederman;Edith R. Lederman;Whitni Davidson;Harold L. Groff;Scott K. Smith

  • The multistep proteolytic maturation pathway utilized by vaccinia virus P4a protein: a degenerate conserved cleavage motif within core proteins.

    Judy K. Vanslyke;Stephen S. Whitehead;Elizabeth M. Wilson;Dennis E. Hruby

  • Development of the small-molecule antiviral ST-246 as a smallpox therapeutic.

    Douglas W Grosenbach;Robert Jordan;Dennis E Hruby

  • Expression and cell type--specific processing of human preproenkephalin with a vaccinia recombinant.

    Gary Thomas;Edward Herbert;Dennis E. Hruby

  • Development of ST-246® for Treatment of Poxvirus Infections.

    Robert Jordan;Janet M. Leeds;Shanthakumar Tyavanagimatt;Dennis E. Hruby

  • The Vaccinia Virus I7L Gene Product Is The Core Protein Proteinase

    Chelsea M. Byrd;Tove' C. Bolken;Dennis E. Hruby;Dennis E. Hruby

  • Conserved DegP Protease in Gram-Positive Bacteria Is Essential for Thermal and Oxidative Tolerance and Full Virulence in Streptococcus pyogenes

    C. Hal Jones;Tove' C. Bolken;Kevin F. Jones;Gloria O. Zeller

  • Interaction of GRASP, a Protein encoded by a Novel Retinoic Acid-induced Gene, with Members of the Cytohesin Family of Guanine Nucleotide Exchange Factors

    Daniel J. Nevrivy;Valerie J. Peterson;Dorina Avram;Jane E. Ishmael

Frequent Co-Authors

Vincent A. Fischetti
Vincent A. Fischetti Rockefeller University
Gary Thomas
Gary Thomas University of Pittsburgh
Stephen S. Whitehead
Stephen S. Whitehead National Institute of Allergy and Infectious Diseases
Olaf Schneewind
Olaf Schneewind University of Chicago
Robert J. Genco
Robert J. Genco University at Buffalo, State University of New York
Howard K. Kuramitsu
Howard K. Kuramitsu University at Buffalo, State University of New York
Robert Snoeck
Robert Snoeck KU Leuven
James H. Strauss
James H. Strauss California Institute of Technology
Erik De Clercq
Erik De Clercq Rega Institute for Medical Research
Graciela Andrei
Graciela Andrei KU Leuven

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