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Biology and Biochemistry

D-Index
61
Citations
21655
World Ranking
11116
National Ranking
4811

Overview

Karen K. Hirschi is affiliated with the University of Virginia in the United States. Their research spans multiple fields with a primary focus on Biochemistry, Genetics, and Molecular Biology, contributing 117 publications. Medicine is another significant area of study, accounting for 49 publications.

Their work encompasses several subfields, including Molecular Biology, Cell Biology, Cancer Research, Immunology, and Genetics. Hirschi's research interests are reflected in a range of main topics such as RNA modifications and cancer, Zebrafish Biomedical Research Applications, Genomics and Phylogenetic Studies, Cancer-related molecular mechanisms research, Angiogenesis and VEGF in Cancer, Single-cell and spatial transcriptomics, and Congenital heart defects research.

Recent papers authored by or associated with Hirschi include:

  • A multi-organ chip with matured tissue niches linked by vascular flow (2022, Nature Biomedical Engineering)
  • Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality (2022, Science)
  • Tet2-mediated clonal hematopoiesis in nonconditioned mice accelerates age-associated cardiac dysfunction (2020, JCI Insight)
  • Tissue-Resident Macrophage Development and Function (2021, Frontiers in Cell and Developmental Biology)
  • Vascular endothelial cell specification in health and disease (2021, Angiogenesis)

Hirschi often collaborates with a set of frequent co-authors, including:

  • Nicholas W. Chavkin
  • Elizabeth A. Nelson
  • Gloria Sheynkman
  • Kenneth Walsh
  • Gaël Genet

The scholar has published extensively across several venues, with the highest number of publications appearing in:

  • Zenodo (CERN European Organization for Nuclear Research)
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Visualized Experiments
  • JCI Insight
  • Angiogenesis

Best Publications

  • Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells

    Kathyjo A. Jackson;Susan M. Majka;Hongyu Wang;Jennifer Pocius

  • Functional arteries grown in vitro.

    L. E. Niklason;Jinming Gao;W. M. Abbott;K. K. Hirschi

  • Clonal hematopoiesis associated with Tet2 deficiency accelerates atherosclerosis development in mice

    José J. Fuster;Susan MacLauchlan;María A. Zuriaga;Maya N. Polackal

  • Pericytes in the microvasculature

    Karen K. Hirschi;Patricia A. D'Amore

  • PDGF, TGF-β, and Heterotypic Cell–Cell Interactions Mediate Endothelial Cell–induced Recruitment of 10T1/2 Cells and Their Differentiation to a Smooth Muscle Fate

    Karen K. Hirschi;Stephanie A. Rohovsky;Patricia Ann D'Amore

  • Assessing Identity, Phenotype, and Fate of Endothelial Progenitor Cells

    Karen K. Hirschi;David A. Ingram;Mervin C. Yoder

  • Endothelial Cells Modulate the Proliferation of Mural Cell Precursors via Platelet-Derived Growth Factor-BB and Heterotypic Cell Contact

    Karen K. Hirschi;Stephanie A. Rohovsky;Laurence H. Beck;Sandra R. Smith

  • The molecular basis of endothelial cell plasticity

    Elisabetta Dejana;Karen K. Hirschi;Michael Simons

  • Coregulation of vascular tube stabilization by endothelial cell TIMP-2 and pericyte TIMP-3.

    W. Brian Saunders;Brenda L. Bohnsack;Jennifer B. Faske;Nicholas J. Anthis

  • Gap junction genes Cx26 and Cx43 individually suppress the cancer phenotype of human mammary carcinoma cells and restore differentiation potential

    Karen K. Hirschi;Cheng-en Xu;Tetsuya Tsukamoto;Ruth Sager

  • Regulation of Endothelial Cell Differentiation and Specification

    Kathrina L. Marcelo;Lauren C. Goldie;Karen K. Hirschi

  • Morphologic and mechanical characteristics of engineered bovine arteries.

    Laura E. Niklason;William Abbott;Jinming Gao;Brian Klagges

  • FGF-dependent metabolic control of vascular development

    Pengchun Yu;Kerstin Wilhelm;Alexandre Dubrac;Joe K. Tung

  • Distinct progenitor populations in skeletal muscle are bone marrow derived and exhibit different cell fates during vascular regeneration

    Susan M. Majka;Kathyjo A. Jackson;Kirsten A. Kienstra;Mark W. Majesky

  • Stem cell plasticity in muscle and bone marrow.

    Margaret A. Goodell;Kathyjo Ann Jackson;Susan M. Majka;Tiejuan Mi

  • A non-canonical Notch complex regulates adherens junctions and vascular barrier function.

    William J. Polacheck;Matthew L. Kutys;Matthew L. Kutys;Jinling Yang;Jinling Yang;Jeroen Eyckmans;Jeroen Eyckmans

  • Comparison of visible and near-infrared wavelength-excitable fluorescent dyes for molecular imaging of cancer.

    Kristen E. Adams;Kristen E. Adams;Shi Ke;Sunkuk Kwon;Feng Liang

  • Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification

    Jennifer S. Fang;Brian G. Coon;Noelle Gillis;Zehua Chen

  • Control of angiogenesis by the pericyte: molecular mechanisms and significance.

    K. K. Hirschi;P. A.` D’Amore

  • Quiescence and Activation of Stem and Precursor Cell Populations in the Subependymal Zone of the Mammalian Brain Are Associated with Distinct Cellular and Extracellular Matrix Signals

    Ilias Kazanis;Justin D. Lathia;Tegy J. Vadakkan;Eric Raborn

Frequent Co-Authors

Margaret A. Goodell
Margaret A. Goodell Baylor College of Medicine
Patricia A. D'Amore
Patricia A. D'Amore Massachusetts Eye and Ear Infirmary
Monica J. Justice
Monica J. Justice Hospital for Sick Children
Kenneth Walsh
Kenneth Walsh University of Virginia
Martin A. Schwartz
Martin A. Schwartz Yale University
Michael Simons
Michael Simons Yale University
Jean-Léon Thomas
Jean-Léon Thomas Yale University
William C. Sessa
William C. Sessa Pfizer (United States)
Christopher S. Chen
Christopher S. Chen Boston University
Anne Eichmann
Anne Eichmann Yale University

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