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Molecular Biology

D-Index
63
Citations
20797
World Ranking
1778
National Ranking
891

Research.com Recognitions

  • 2010 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Roger Brent is affiliated with the Fred Hutchinson Cancer Research Center in the United States. Their research primarily spans the field of Biochemistry, Genetics, and Molecular Biology, with specific focus on Molecular Biology as the dominant subfield.

The scientist's recent work includes studies published in a range of journals and platforms. Notable papers are:

  • A precisely adjustable, variation-suppressed eukaryotic transcriptional controller to enable genetic discovery, 2021, eLife
  • Autorepression-Based Conditional Gene Expression System in Yeast for Variation-Suppressed Control of Protein Dosage, 2023, Current Protocols
  • Individual yeast cells signal at different levels but each with good precision, 2025, Royal Society Open Science
  • Individual yeast cells signal at different levels but each with good precision, 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • Autorepression-based conditional gene expression system in yeast for variation-suppressed control of protein dosage, 2022, bioRxiv (Cold Spring Harbor Laboratory)

These publications reflect an ongoing interest in genetic control mechanisms, particularly in yeast, and the modulation of gene expression variability.

Roger Brent has collaborated frequently with several coauthors, most notably:

  • Aslı Azizoğlu
  • Jonathan E. Venetz
  • Steven S. Andrews
  • Fabian Rudolf
  • Cristina Loureiro

The scientist's work has appeared mainly in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • eLife
  • Current Protocols
  • Royal Society Open Science

Their research touches on topics such as:

  • CRISPR and Genetic Engineering
  • Gene Regulatory Network Analysis
  • Fungal and yeast genetics research
  • RNA and protein synthesis mechanisms
  • Microbial Metabolic Engineering and Bioproduction
  • Bioinformatics and Genomic Networks
  • Cell Image Analysis Techniques

In 2010, Roger Brent was recognized as a Fellow of the American Association for the Advancement of Science (AAAS).

Best Publications

  • Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2

    Jenő Gyuris;Erica Golemis;Helen Chertkov;Roger Brent

  • Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites

    Antonis S. Zervos;Jenő Gyuris;Roger Brent

  • A eukaryotic transcriptional activator bearing the DNA specificity of a prokaryotic repressor

    Roger Brent;Mark Ptashne

  • Correlation of two-hybrid affinity data with in vitro measurements.

    J Estojak;R Brent;E A Golemis

  • Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins

    Paroush Z;Finley Rl;Kidd T;Wainwright Sm

  • A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology

    Markus Herrgard;Neil Swainston;Paul Dobson;Warwick B. Dunn

  • Interaction Trap/Two-Hybrid System to Identify Interacting Proteins

    Erica A. Golemis;Ilya Serebriiskii;Russell L. Finley;Mikhail G. Kolonin

  • Mechanism of action of the lexA gene product

    Roger Brent;Mark Ptashne

  • APC binds to the novel protein EB1

    Lio-Kuo Su;Marilee Burrell;David E Hill;Jenö Gyuris

  • DNA specificity of the bicoid activator protein is determined by homeodomain recognition helix residue 9

    Steven D. Hanes;Roger Brent

  • Genetic selection of peptide aptamers that recognize and inhibit cyclin-dependent kinase 2

    Pierre Colas;Barak Cohen;Timm Jessen;Irina Grishina

  • TWO CLASSES OF PROTEINS DEPENDENT ON EITHER THE PRESENCE OR ABSENCE OF THYROID HORMONE FOR INTERACTION WITH THE THYROID HORMONE RECEPTOR

    Jae Woon Lee;Hueng Sik Choi;Jeno Gyuris;Roger Brent

  • Modelling cellular behaviour.

    Drew Endy;Roger Brent

  • Regulated cell-to-cell variation in a cell-fate decision system

    Alejandro Colman-Lerner;Andrew Gordon;Eduard Serra;Tina Chin

  • INTERACTION MATING REVEALS BINARY AND TERNARY CONNECTIONS BETWEEN DROSOPHILA CELL CYCLE REGULATORS

    Russell L. Finley;Roger Brent

  • Yeast Cbk1 and Mob2 activate daughter-specific genetic programs to induce asymmetric cell fates.

    Alejandro Colman-Lerner;Tina E. Chin;Roger Brent

  • Detailed Simulations of Cell Biology with Smoldyn 2.1

    Steven S. Andrews;Nathan J. Addy;Roger Brent;Adam P. Arkin;Adam P. Arkin

  • A bacterial repressor protein or a yeast transcriptional terminator can block upstream activation of a yeast gene

    Roger Brent;Mark Ptashne

  • Interaction trap system for isolating proteins

    Roger Dr. Brent;Jeno Gyuris;Erica Golemis

  • A genetic model for interaction of the homeodomain recognition helix with DNA.

    Steven D. Hanes;Roger Brent

Frequent Co-Authors

Erica A. Golemis
Erica A. Golemis Fox Chase Cancer Center
Mark Ptashne
Mark Ptashne Memorial Sloan Kettering Cancer Center
Pamela A. Silver
Pamela A. Silver Harvard University
Eirikur Steingrimsson
Eirikur Steingrimsson University of Iceland
Richard D. Smith
Richard D. Smith Pacific Northwest National Laboratory
Adam P. Arkin
Adam P. Arkin Lawrence Berkeley National Laboratory
Neal G. Copeland
Neal G. Copeland The University of Texas MD Anderson Cancer Center
Nancy A. Jenkins
Nancy A. Jenkins The University of Texas MD Anderson Cancer Center
Andrea Ballabio
Andrea Ballabio Baylor College of Medicine
David H. Ledbetter
David H. Ledbetter University of Florida

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