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D-Index & Metrics

Biology and Biochemistry

D-Index
55
Citations
17769
World Ranking
14786
National Ranking
6184

Overview

Donald E. Ayer is affiliated with the University of Utah in the United States. Their research primarily spans the fields of Biochemistry, Genetics, and Molecular Biology, with significant contributions also in Medicine. Within these broader areas, their work frequently addresses subfields such as Molecular Biology, Epidemiology, Cancer Research, Physiology, and Genetics.

Ayer's research topics cover multiple areas including Ubiquitin and proteasome pathways, Autophagy in Disease and Therapy, Cancer, Hypoxia, and Metabolism, Genomics and Chromatin Dynamics, Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities, Metabolism, Diabetes, and Cancer, as well as Sirtuins and Resveratrol in Medicine.

The scientist has recently contributed to several papers, demonstrating a focus on cellular senescence, metabolism, and transcriptional regulation. Notable publications include:

  • Age-associated decline of MondoA drives cellular senescence through impaired autophagy and mitochondrial homeostasis, 2022, Cell Reports
  • The glucose-sensing transcription factor MLX balances metabolism and stress to suppress apoptosis and maintain spermatogenesis, 2021, PLoS Biology
  • Protein synthesis inhibitors stimulate MondoA transcriptional activity by driving an accumulation of glucose 6-phosphate, 2020, Cancer & Metabolism
  • TXNIP loss expands Myc-dependent transcriptional programs by increasing Myc genomic binding, 2023, PLoS Biology
  • MLX balances metabolism and stress to suppress apoptosis and maintain spermatogenesis, 2020, bioRxiv (Cold Spring Harbor Laboratory)

Ayer collaborates frequently with several coauthors, including Blake R. Wilde, Patrick A. Carroll, Brian Freie, Pei Cheng, and Sivakanthan Kasinathan.

Their work is published in venues such as bioRxiv (Cold Spring Harbor Laboratory), PLoS Biology, Cell Reports, Cancer & Metabolism, and Cell Chemical Biology. The presence of multiple publications in bioRxiv and PLoS Biology indicates a strong engagement with both preprint dissemination and peer-reviewed journals.

Best Publications

  • Max: a helix-loop-helix zipper protein that forms a sequence-specific dna-binding complex with myc and mad

    Elizabeth Marie Blackwood;Robert Neil Eisenman;Donald E. Ayer

  • Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase.

    Laszlo Nagy;Hung Ying Kao;Debabrata Chakravarti;Richard J. Lin

  • ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression

    Xiaobing Shi;Tao Hong;Kay L. Walter;Mark Ewalt

  • Histone deacetylase activity is required for full transcriptional repression by mSin3A.

    Christian A Hassig;Tracey C Fleischer;Andrew N Billin;Stuart L Schreiber

  • Mad: A heterodimeric partner for Max that antagonizes Myc transcriptional activity

    Donald E. Ayer;Leo Kretzner;Robert N. Eisenman

  • Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3.

    Donald E Ayer;Quentin A Lawrence;Robert N Eisenman

  • A role for histone deacetylase activity in HDAC1-mediated transcriptional repression

    Christian A. Hassig;Jeffrey K. Tong;Tracey C. Fleischer;Takashi Owa

  • Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

    Franz X. Schaub;Varsha Dhankani;Ashton C. Berger;Mihir Trivedi

  • A switch from Myc:Max to Mad:Max heterocomplexes accompanies monocyte/macrophage differentiation.

    Donald E. Ayer;Robert N. Eisenman

  • Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation.

    Peter J. Hurlin;Christophe Quéva;Päivi J. Koskinen;Eiríkur Steingrímsson

  • Histone deacetylases: transcriptional repression with SINers and NuRDs.

    Donald E Ayer

  • Glucose sensing by MondoA:Mlx complexes: A role for hexokinases and direct regulation of thioredoxin-interacting protein expression

    Carrie A. Stoltzman;Christopher W. Peterson;Kevin T. Breen;Deborah M. Muoio

  • β-Catenin–Histone Deacetylase Interactions Regulate the Transition of LEF1 from a Transcriptional Repressor to an Activator

    Andrew N. Billin;Hilary Thirlwell;Donald E. Ayer

  • Response of BRAF-Mutant Melanoma to BRAF Inhibition Is Mediated by a Network of Transcriptional Regulators of Glycolysis

    Tiffany J. Parmenter;Margarete Kleinschmidt;Kathryn M. Kinross;Simon T. Bond

  • Myc-Max heterodimers activate a DEAD box gene and interact with multiple E box-related sites in vivo.

    Carla Grandori;Jaclynn Mac;Friederike Siëbelt;Donald E. Ayer

  • SAP30, a Component of the mSin3 Corepressor Complex Involved in N-CoR-Mediated Repression by Specific Transcription Factors

    Carol D. Laherty;Andrew N. Billin;Robert M. Lavinsky;Gregory S. Yochum

  • Identification and Characterization of Three New Components of the mSin3A Corepressor Complex

    Tracey C. Fleischer;Ui Jeong Yun;Donald E. Ayer

  • Metabolic reprogramming in triple-negative breast cancer through Myc suppression of TXNIP

    Liangliang Shen;Liangliang Shen;John M. O’Shea;Mohan R. Kaadige;Stéphanie Cunha

  • Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization

    William J. Sullivan;Peter J. Mullen;Ernst W. Schmid;Aimee A. Flores

  • Mad Proteins Contain a Dominant Transcription Repression Domain

    Donald E. Ayer;Carol D. Laherty;Quentin A. Lawrence;Allison P. Armstrong

Frequent Co-Authors

Robert N. Eisenman
Robert N. Eisenman Fred Hutchinson Cancer Research Center
Daniel Raftery
Daniel Raftery University of Washington
Grant A. McArthur
Grant A. McArthur Peter MacCallum Cancer Centre
Georgina V. Long
Georgina V. Long University of Sydney
Stuart L. Schreiber
Stuart L. Schreiber Harvard University
Richard A. Scolyer
Richard A. Scolyer Royal Prince Alfred Hospital
Katrin F. Chua
Katrin F. Chua Stanford University
Carleen Cullinane
Carleen Cullinane Peter MacCallum Cancer Centre
Helen Rizos
Helen Rizos Macquarie University
Jay Shendure
Jay Shendure University of Washington

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