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Overview

Caroline Seynaeve is a researcher affiliated with Erasmus University Rotterdam in the Netherlands. Their work primarily focuses on the fields of biochemistry, genetics, and molecular biology, with a significant emphasis on medicine. Seynaeve's research contributions span various subfields, particularly cancer research, genetics, oncology, pulmonary and respiratory medicine, and radiology, nuclear medicine, and imaging.

The main topics explored in Seynaeve's research include breast cancer treatment studies, advanced breast cancer therapies, estrogen and related hormone effects, HER2/EGFR in cancer research, BRCA gene mutations in cancer, cancer risks and factors, and monoclonal and polyclonal antibodies research.

Frequent publication venues for Seynaeve's work are:

  • Journal of Clinical Oncology
  • Annals of Oncology
  • Cancer Research
  • Journal of Molecular Diagnostics
  • JAMA Oncology

Notable recent papers authored or co-authored by Seynaeve include:

  • Overestimation of Late Distant Recurrences in High-Risk Patients With ER-Positive Breast Cancer: Validity and Accuracy of the CTS5 Risk Score in the TEAM and IDEAL Trials (2020, Journal of Clinical Oncology)
  • Discordance between Immunohistochemistry and Erb-B2 Receptor Tyrosine Kinase 2 mRNA to Determine Human Epidermal Growth Factor Receptor 2 Low Status for Breast Cancer (2022, Journal of Molecular Diagnostics)
  • High-Dose Chemotherapy With Hematopoietic Stem Cell Transplant in Patients With High-Risk Breast Cancer and 4 or More Involved Axillary Lymph Nodes (2020, JAMA Oncology)
  • Ten-year distant-recurrence risk prediction in breast cancer by CanAssist Breast (CAB) in Dutch sub-cohort of the randomized TEAM trial (2023, Breast Cancer Research)
  • Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent (2020, UNC Libraries)

Caroline Seynaeve regularly collaborates with several co-authors, including:

  • Cornelis J. H. van de Velde
  • Annette Hasenburg
  • Christos Markopoulos
  • John M. S. Bartlett
  • Daniel Rea

The consistent focus on breast cancer in Seynaeve's research aligns with their extensive publication record in cancer research and oncology. Their contributions contribute to ongoing studies analyzing breast cancer treatment methodologies, hormone-related effects, and genetic risk factors.

Best Publications

  • Association analysis identifies 65 new breast cancer risk loci

    Kyriaki Michailidou;Kyriaki Michailidou;Sara Lindström;Sara Lindström;Joe Dennis;Jonathan Beesley

  • Breast cancer after prophylactic bilateral mastectomy in women with a BRCA1 or BRCA2 mutation

    Hanne Meijers-Heijboer;Bert van Geel;Wim L.J. van Putten;Sonja C. Henzen-Logmans

  • Large-scale genotyping identifies 41 new loci associated with breast cancer risk

    Kyriaki Michailidou;Per Hall;Anna Gonzalez-Neira;Maya Ghoussaini

  • RAD51B in Familial Breast Cancer

    Liisa M. Pelttari;Sofia Khan;Mikko Vuorela;Johanna I. Kiiski

  • Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes

    Nasim Mavaddat;Kyriaki Michailidou;Kyriaki Michailidou;Joe Dennis;Michael Lush

  • Associations of Breast Cancer Risk Factors With Tumor Subtypes: A Pooled Analysis From the Breast Cancer Association Consortium Studies

    Xiaohong R. Yang;Jenny Chang-Claude;Ellen L. Goode;Fergus J. Couch

  • Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer

    Kyriaki Michailidou;Jonathan Beesley;Sara Lindstrom;Sander Canisius

  • Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

    Stig E. Bojesen;Stig E. Bojesen;Karen A. Pooley;Sharon E. Johnatty;Jonathan Beesley

  • Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants

    Nasim Mavaddat;Paul D.P. Pharoah;Kyriaki Michailidou;Jonathan Tyrer

  • MicroRNA related polymorphisms and breast cancer risk

    Sofia Khan;Dario Greco;Dario Greco;Kyriaki Michailidou;Roger L. Milne;Roger L. Milne

  • Micrometastases or Isolated Tumor Cells and the Outcome of Breast Cancer

    Maaike de Boer;Carolien H.M. van Deurzen;Jos A.A.M. van Dijck;George F. Borm

  • Neuropsychological Performance in Survivors of Breast Cancer More Than 20 Years After Adjuvant Chemotherapy

    Vincent Koppelmans;Monique M.B. Breteler;Willem Boogerd;Caroline Seynaeve

  • Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2.

    Shahana Ahmed;Gilles Thomas;Maya Ghoussaini;Catherine S. Healey

  • Survival and tumour characteristics of breast-cancer patients with germline mutations of BRCA1

    LC Verhoog;Ctm Brekelmans;C Seynaeve;Lmc van den Bosch

  • Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer.

    Timothy R. Rebbeck;Nandita Mitra;Fei Wan;Olga M. Sinilnikova

  • Adjuvant tamoxifen and exemestane in early breast cancer (TEAM): a randomised phase 3 trial

    Cornelis J H van de Velde;Daniel Rea;Caroline Seynaeve;Hein Putter

  • Presymptomatic DNA testing and prophylactic surgery in families with a BRCA1 or BRCA2 mutation

    EJ Meijers-Heijboer;LC Verhoog;Ctm Brekelmans;C Seynaeve

  • Effectiveness of Breast Cancer Surveillance in BRCA1/2 Gene Mutation Carriers and Women With High Familial Risk

    C.T.M. Brekelmans;C. Seynaeve;C.C.M. Bartels;M.M.A. Tilanus-Linthorst

  • Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk

    Fergus J. Couch;Xianshu Wang;Lesley McGuffog;Andrew Lee

  • Survival and Tumour Characteristics of Breast-Cancer Patients with Germline Mutations of BRCA1

    L. C. Verhoog;C. T. M. Brekelmans;C. Seynaeve;L. M. C. Van Den Bosch

Frequent Co-Authors

Hiltrud Brauch
Hiltrud Brauch German Cancer Research Center
Graham G. Giles
Graham G. Giles University of Melbourne
Roger L. Milne
Roger L. Milne Cancer Council Victoria
Peter Devilee
Peter Devilee Leiden University Medical Center
Irene L. Andrulis
Irene L. Andrulis University of Toronto
Barbara Burwinkel
Barbara Burwinkel Heidelberg University
Jenny Chang-Claude
Jenny Chang-Claude German Cancer Research Center
Douglas F. Easton
Douglas F. Easton University of Cambridge
Stig E. Bojesen
Stig E. Bojesen University of Copenhagen
Fergus J. Couch
Fergus J. Couch Mayo Clinic

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