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Biology and Biochemistry

D-Index
86
Citations
23342
World Ranking
3021
National Ranking
1536

Overview

Bechara Kachar is affiliated with the National Institutes of Health in the United States. Their research spans several areas within biochemistry, genetics, molecular biology, and neuroscience, with a particular focus on hearing-related processes and disorders. The primary fields of study include biochemistry, genetics, molecular biology, and neuroscience, supported by subfields such as molecular biology, sensory systems, physiology, cell biology, and neurology.

Their work addresses a range of topics including hearing, cochlea, tinnitus, genetics, erythrocyte function and pathophysiology, vestibular and auditory disorders, RNA regulation and disease, connexins and lens biology, calcium signaling and nucleotide metabolism, and skin and cellular biology research.

Bechara Kachar's recent publications include:

  • Myosin-VIIa is expressed in multiple isoforms and essential for tensioning the hair cell mechanotransduction complex, 2020, Nature Communications
  • T cell protein tyrosine phosphatase protects intestinal barrier function by restricting epithelial tight junction remodeling, 2021, Journal of Clinical Investigation
  • Nanoarchitecture and dynamics of the mouse enteric glycocalyx examined by freeze-etching electron tomography and intravital microscopy, 2020, Communications Biology
  • Mutation of SLC7A14 causes auditory neuropathy and retinitis pigmentosa mediated by lysosomal dysfunction, 2022, Science Advances
  • Selective binding and transport of protocadherin 15 isoforms by stereocilia unconventional myosins in a heterologous expression system, 2022, Scientific Reports

Their frequent co-authors include Runjia Cui, Seham Ebrahim, Evan Krystofiak, Huizhan Liu, and David Z. Z. He.

Bechara Kachar's publications often appear in specific venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Scientific Reports, Journal of Clinical Investigation, and Communications Biology.

Best Publications

  • Determination of elastic moduli of thin layers of soft material using the atomic force microscope.

    Emilios K. Dimitriadis;Ferenc Horkay;Julia Maresca;Bechara Kachar

  • CNS Myelin and Sertoli Cell Tight Junction Strands Are Absent in Osp/Claudin-11 Null Mice

    Alexander Gow;Cherie M Southwood;Jing Song Li;Milena Pariali

  • Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells.

    Piotr Kazmierczak;Hirofumi Sakaguchi;Joshua Tokita;Elizabeth M. Wilson-Kubalek

  • Mutations in the gene encoding tight junction claudin-14 cause autosomal recessive deafness DFNB29.

    Edward R Wilcox;Quianna L Burton;Sadaf Naz;Saima Riazuddin;Saima Riazuddin

  • Mutations in Cdh23, encoding a new type of cadherin, cause stereocilia disorganization in waltzer, the mouse model for Usher syndrome type 1D.

    Federica Di Palma;Ralph H. Holme;Elizabeth C. Bryda;Inna A. Belyantseva

  • Targeted disruption of mouse Pds provides insight about the inner-ear defects encountered in Pendred syndrome

    Lorraine A. Everett;Inna A. Belyantseva;Konrad Noben-Trauth;Raquel Cantos

  • Electrokinetic shape changes of cochlear outer hair cells

    Bechara Kachar;William E. Brownell;Richard Altschuler;Jörgen Fex

  • A role for actin arcs in the leading-edge advance of migrating cells

    Dylan T. Burnette;Suliana Manley;Prabuddha Sengupta;Rachid Sougrat

  • Liquid-crystalline solvents as mechanistic probes. Part 37. Novel family of gelators of organic fluids and the structure of their gels

    Yih Chyuan Lin;Bechara Kachar;Richard G. Weiss

  • An actin molecular treadmill and myosins maintain stereocilia functional architecture and self-renewal

    Agnieszka K. Rzadzinska;Mark E. Schneider;Caroline Davies;Gavin P. Riordan

  • The cell biology of hearing

    Martin Schwander;Bechara Kachar;Ulrich Müller

  • Evidence for the lipidic nature of tight junction strands

    Bechara Kachar;Thomas S. Reese

  • High-resolution structure of hair-cell tip links.

    Bechara Kachar;Marianne Parakkal;Mauricio Kurc;Yi Dong Zhao

  • A membrane-based force generation mechanism in auditory sensory cells.

    Federico Kalinec;Matthew C. Holley;Kuni H. Iwasa;David J. Lim

  • Ablation of uroplakin III gene results in small urothelial plaques, urothelial leakage, and vesicoureteral reflux.

    P Hu;F.-M Deng;F.-X Liang;C.-M Hu

  • Role of membrane proteins in permeability barrier function: uroplakin ablation elevates urothelial permeability

    Ping Hu;Susan Meyers;Feng-Xia Liang;Fang-Ming Deng

  • Expression and localization of prestin and the sugar transporter GLUT-5 during development of electromotility in cochlear outer hair cells.

    Inna A. Belyantseva;Henry J. Adler;Rui Curi;Gregory I. Frolenkov

  • On tight-junction structure

    Pedro Pinto da Silva;Bechara Kachar

  • Mutations in Mcoln3 associated with deafness and pigmentation defects in varitint-waddler (Va) mice.

    Federica Di Palma;Inna A. Belyantseva;Hung J. Kim;Thomas F. Vogt

  • The mechanism of cytoplasmic streaming in characean algal cells: sliding of endoplasmic reticulum along actin filaments.

    Bechara Kachar;T. S. Reese

Frequent Co-Authors

Inna A. Belyantseva
Inna A. Belyantseva National Institutes of Health
Thomas S. Reese
Thomas S. Reese National Institutes of Health
Raul Urrutia
Raul Urrutia Medical College of Wisconsin
Ronald S. Petralia
Ronald S. Petralia National Institutes of Health
Jörgen Fex
Jörgen Fex National Institutes of Health
Ulrich Müller
Ulrich Müller Johns Hopkins University School of Medicine
Robert J. Wenthold
Robert J. Wenthold National Institutes of Health
Tung-Tien Sun
Tung-Tien Sun New York University
Karen P. Steel
Karen P. Steel King's College London
Thomas B. Friedman
Thomas B. Friedman National Institutes of Health

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