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Neuroscience
Taiwan
2026

D-Index & Metrics

Neuroscience

D-Index
51
Citations
8916
World Ranking
5550
National Ranking
13

Research.com Recognitions

  • 2026 - Research.com Neuroscience in Taiwan Leader Award
  • 2025 - Research.com Neuroscience in Taiwan Leader Award

Overview

Samuel H.H. Chan is affiliated with Chang Gung Memorial Hospital in Taiwan. Their research spans multiple fields within medicine and biological sciences, with a focus on surgery, pulmonary and respiratory medicine, molecular biology, oncology, and cardiology and cardiovascular medicine. Chan's work covers areas such as organ transplantation techniques and outcomes, anesthesia and pain management, lung cancer treatments and mutations, anesthesia and neurotoxicity research, traumatic brain injury and neurovascular disturbances, and pancreatic and hepatic oncology research.

The scientist has contributed to at least 42 publications in Medicine and 9 in Biochemistry, Genetics and Molecular Biology. Their subfield interests include surgery, pulmonary and respiratory medicine, molecular biology, oncology, and cardiovascular medicine.

Significant recent publications by Samuel H.H. Chan include:

  • Systemic therapy for pre-treated malignant mesothelioma: A systematic review, meta-analysis and network meta-analysis of randomised controlled trials, 2022, European Journal of Cancer
  • Protective role of VEGF/VEGFR2 signaling against high fatality associated with hepatic encephalopathy via sustaining mitochondrial bioenergetics functions, 2022, Journal of Biomedical Science
  • Disproportional cardiovascular depressive effects of isoflurane: Serendipitous findings from a comprehensive re-visit in mice, 2020, Lab Animal
  • Immunotherapy-related adverse events in real-world patients with advanced non-small cell lung cancer on chemoimmunotherapy: a Spinnaker study sub-analysis, 2023, Frontiers in Oncology
  • Postoperative Stroke after Spinal Anesthesia and Responses of Carotid or Cerebral Blood Flow and Baroreflex Functionality to Spinal Bupivacaine in Rats, 2021, Biology

Frequent co-authors with multiple collaborative works include:

  • Ching-Yi Tsai
  • Giuseppe Luigi Banna
  • Alessio Signori
  • Alessio Cortellini
  • Alfredo Addeo

Samuel H.H. Chan's publications have appeared in a range of journals and venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • European Journal of Cancer
  • Journal of Biomedical Science
  • Frontiers in Oncology
  • Lab Animal

In addition to journal articles, the scientist has contributed to book publications, notably a work titled Brain Stem Death, published in 2022 within the series Translational Research in Biomedicine.

Best Publications

  • Effects of long-term antiepileptic drug monotherapy on vascular risk factors and atherosclerosis.

    Yao-Chung Chuang;Hung-Yi Chuang;Tsu-Kung Lin;Chiung-Chih Chang

  • NADPH Oxidase–Derived Superoxide Anion Mediates Angiotensin II–Induced Pressor Effect via Activation of p38 Mitogen–Activated Protein Kinase in the Rostral Ventrolateral Medulla

    Samuel H.H. Chan;Kuei-Sen Hsu;Chiung-Chun Huang;Ling-Lin Wang

  • Spectral analysis of systemic arterial pressure and heart rate signals as a prognostic tool for the prediction of patient outcome in the intensive care unit

    Huey Wen Yien;Shu Shya Hseu;Lih Chyn Lee;Terry B.J. Kuo

  • Neuroinflammation and oxidative stress in rostral ventrolateral medulla contribute to neurogenic hypertension induced by systemic inflammation

    Unknown

  • Reduction in molecular synthesis or enzyme activity of superoxide dismutases and catalase contributes to oxidative stress and neurogenic hypertension in spontaneously hypertensive rats

    Samuel H.H. Chan;Ming-Hon Tai;Chia-Yen Li;Julie Y.H. Chan

  • Mitochondrial dysfunction and ultrastructural damage in the hippocampus during kainic acid-induced status epilepticus in the rat.

    Yao-Chung Chuang;Alice Y. W. Chang;Jui-Wei Lin;Shih-Pin Hsu

  • Continuous, on-line, real-time spectral analysis of systemic arterial pressure signals

    T. B.J. Kuo;S. H.H. Chan

  • Oxidative Impairment of Mitochondrial Electron Transport Chain Complexes in Rostral Ventrolateral Medulla Contributes to Neurogenic Hypertension

    Samuel H.H. Chan;Kay L.H. Wu;Alice Y.W. Chang;Ming Hon Tai

  • Differential cardiovascular responses to blockade of nNOS or iNOS in rostral ventrolateral medulla of the rat.

    Samuel H H Chan;Ling-Lin Wang;Shu-Huei Wang;Julie Y H Chan

  • Effects of propofol on nociceptive response and power spectra of electroencephalographic and systemic arterial pressure signals in the rat: correlation with plasma concentration.

    Chen-Hsien Yang;Ming-Hwang Shyr;T. B. J. Kuo;P. P. C. Tan

  • Heat Shock Protein 70 Confers Cardiovascular Protection During Endotoxemia via Inhibition of Nuclear Factor-κB Activation and Inducible Nitric Oxide Synthase Expression in the Rostral Ventrolateral Medulla

    Julie Y.H. Chan;Chen-Chun Ou;Ling-Lin Wang;Samuel H.H. Chan

  • Auto- and cross-spectral analysis of cardiovascular fluctuations during pentobarbital anesthesia in the rat.

    Cheryl C.H. Yang;Terry B.J. Kuo;Samuel H.H. Chan

  • Selective activation of vasomotor component of SAP spectrum by nucleus reticularis ventrolateralis in rats

    Terry B.J. Kuo;Cheryl C.H. Yang;Samuel H.H. Chan

  • Concentration and regional distribution of propofol in brain and spinal cord during propofol anesthesia in the rat.

    Ming Hwang Shyr;Tung Hu Tsai;Peter P.C. Tan;Chieh Fu Chen

  • What is being stimulated in acupuncture: evaluation of the existence of a specific substrate.

    Samuel H.H. Chan

  • Participation of Paraventricular Nucleus of Hypothalamus in Central Regulation of Penile Erection in the Rat

    Kuang-Kuo Chen;Samuel H.H. Chan;Luke S. Chang;Julie Y.H. Chan

  • Potentiation of Baroreceptor Reflex Response by Heat Shock Protein 70 in Nucleus Tractus Solitarii Confers Cardiovascular Protection During Heatstroke

    Pei-Lun Li;Yung-Mei Chao;Samuel H. H. Chan;Julie Y. H. Chan

  • Transcriptional Upregulation of Brain-Derived Neurotrophic Factor in Rostral Ventrolateral Medulla by Angiotensin II Significance in Superoxide Homeostasis and Neural Regulation of Arterial Pressure

    Samuel H.H. Chan;Chih Wei J. Wu;Alice Y.W. Chang;Kuei Sen Hsu

  • Diminished vasomotor component of systemic arterial pressure signals and baroreflex in brain death

    Terry B.J. Kuo;Huey Wen Yien;Shu Shya Hseu;Cheryl C.H. Yang

  • Facilitation of lumbar monosynaptic reflexes by locus coeruleus in the rat

    Julie Y.H. Chan;Simon J. Fung;Samuel H.H. Chan;Charles D. Barnes

  • Upregulation of AT1 receptor gene on activation of protein kinase Cbeta/nicotinamide adenine dinucleotide diphosphate oxidase/ERK1/2/c-fos signaling cascade mediates long-term pressor effect of angiotensin II in rostral ventrolateral medulla.

    Samuel H. H. Chan;Ling-Lin Wang;Huey-Ling Tseng;Julie Y. H. Chan

Frequent Co-Authors

Julie Y.H. Chan
Julie Y.H. Chan Kaohsiung Chang Gung Memorial Hospital
Kuei Sen Hsu
Kuei Sen Hsu National Cheng Kung University
Chiung Chun Huang
Chiung Chun Huang National Cheng Kung University
Ming-Yang Lai
Ming-Yang Lai National Taiwan University
Yung-Yang Lin
Yung-Yang Lin National Yang Ming Chiao Tung University

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