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Immunology

D-Index
93
Citations
31555
World Ranking
970
National Ranking
533

Overview

Mariana J. Kaplan is affiliated with the National Institutes of Health in the United States. Their research contributions focus primarily on medicine and immunology and microbiology, with a significant number of publications in subfields such as immunology, rheumatology, molecular biology, immunology and allergy, and epidemiology.

The scientist's main research topics cover a range of immune system functions and diseases, including:

  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Systemic Lupus Erythematosus Research
  • Inflammasome and immune disorders
  • Immune cells in cancer
  • Immune Response and Inflammation
  • Cell Adhesion Molecules Research
  • Immune Cell Function and Interaction

Mariana J. Kaplan has been involved in numerous publications across a variety of scientific journals. Frequent publication venues include:

  • Arthritis & Rheumatology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Journal of Immunology
  • Annals of the Rheumatic Diseases
  • Frontiers in Immunology

Recent key papers authored or co-authored by Mariana J. Kaplan span topics related to autoinflammatory disease, neutrophil functions, and autoimmune disorders. Notable recent papers are:

  • Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease (2020, New England Journal of Medicine)
  • Neutrophil extracellular traps in systemic autoimmune and autoinflammatory diseases (2022, Nature reviews. Immunology)
  • Neutrophil phenotypes and functions in cancer: A consensus statement (2022, The Journal of Experimental Medicine)
  • Patients with COVID-19: in the dark-NETs of neutrophils (2021, Cell Death and Differentiation)
  • Somatic Mutations in UBA1 Define a Distinct Subset of Relapsing Polychondritis Patients With VEXAS (2021, Arthritis & Rheumatology)

Mariana J. Kaplan frequently collaborates with several co-authors, among the most common are:

  • Carmelo Carmona-Rivera
  • Shuichiro Nakabo
  • Sarfaraz Hasni
  • Sarthak Gupta
  • Richard Bucala

Best Publications

  • NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis

    Ritika Khandpur;Carmelo Carmona-Rivera;Anuradha Vivekanandan-Giri;Alison Gizinski

  • Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity

    Mariana J. Kaplan;Marko Radic

  • Netting Neutrophils Induce Endothelial Damage, Infiltrate Tissues, and Expose Immunostimulatory Molecules in Systemic Lupus Erythematosus

    Eneida Villanueva;Srilakshmi Yalavarthi;Celine C. Berthier;Jeffrey B. Hodgin

  • Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease.

    David B. Beck;Marcela A. Ferrada;Keith A. Sikora;Amanda K. Ombrello

  • Mast Cells and Neutrophils Release IL-17 through Extracellular Trap Formation in Psoriasis

    Andrew M. Lin;Cory J. Rubin;Ritika Khandpur;Jennifer Y. Wang

  • A Distinct Subset of Proinflammatory Neutrophils Isolated from Patients with Systemic Lupus Erythematosus Induces Vascular Damage and Synthesizes Type I IFNs

    Michael F. Denny;Srilakshmi Yalavarthi;Wenpu Zhao;Seth G. Thacker

  • VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease.

    Jeonghan Kim;Rajeev Gupta;Luz P. Blanco;Shutong Yang

  • Neutrophil Extracellular Trap–Associated Protein Activation of the NLRP3 Inflammasome Is Enhanced in Lupus Macrophages

    J. Michelle Kahlenberg;Carmelo Carmona-Rivera;Carolyne K. Smith;Mariana J. Kaplan

  • Little Peptide, Big Effects: The Role of LL-37 in Inflammation and Autoimmune Disease

    J. Michelle Kahlenberg;Mariana J. Kaplan

  • Peptidylarginine Deiminase Inhibition Reduces Vascular Damage and Modulates Innate Immune Responses in Murine Models of Atherosclerosis

    Jason S. Knight;Wei Luo;Alexander A. O’Dell;Srilakshmi Yalavarthi

  • Neutrophil extracellular traps induce endothelial dysfunction in systemic lupus erythematosus through the activation of matrix metalloproteinase-2

    Carmelo Carmona-Rivera;Wenpu Zhao;Srilakshmi Yalavarthi;Mariana J Kaplan

  • The role of neutrophils and NETosis in autoimmune and renal diseases

    Sarthak Gupta;Mariana J. Kaplan

  • Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice

    Jason S Knight;Venkataraman Subramanian;Alexander A O'Dell;Srilakshmi Yalavarthi

  • To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps

    Sebastian Boeltz;Poorya Amini;Hans Joachim Anders;Felipe Andrade

  • Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus

    Jason S. Knight;Wenpu Zhao;Wei Luo;Venkataraman Subramanian

  • Low density granulocytes: a distinct class of neutrophils in systemic autoimmunity

    Carmelo Carmona-Rivera;Mariana J. Kaplan

  • Neutrophils in the pathogenesis and manifestations of SLE.

    Mariana J. Kaplan

  • Demethylation of ITGAL (CD11a) regulatory sequences in systemic lupus erythematosus.

    Qianjin Lu;Mariana J. Kaplan;Donna Ray;Doreen Ray

  • Endothelial cell apoptosis in systemic lupus erythematosus: a common pathway for abnormal vascular function and thrombosis propensity

    Sanjay Rajagopalan;Emily C. Somers;Robert D. Brook;Christine Kehrer

  • Interferon-α promotes abnormal vasculogenesis in lupus: a potential pathway for premature atherosclerosis

    Michael F. Denny;Seth Thacker;Hemal Mehta;Emily C. Somers

Frequent Co-Authors

Jason S. Knight
Jason S. Knight University of Michigan–Ann Arbor
Bruce C. Richardson
Bruce C. Richardson University of Michigan–Ann Arbor
Robert D. Brook
Robert D. Brook University of Michigan–Ann Arbor
Marko Z. Radic
Marko Z. Radic University of Tennessee Health Science Center
Richard M. Siegel
Richard M. Siegel National Institutes of Health
Alan T. Remaley
Alan T. Remaley National Institutes of Health
Ivona Aksentijevich
Ivona Aksentijevich National Institutes of Health
David A. Fox
David A. Fox University of Michigan–Ann Arbor
Claudia Kemper
Claudia Kemper National Institutes of Health
Michael Davis
Michael Davis Georgia Institute of Technology

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