His primary areas of investigation include Internal medicine, Endocrinology, Genetics, Cell biology and Peroxisome proliferator-activated receptor. In his research, Proinflammatory cytokine and Vascular smooth muscle is intimately related to Macrophage, which falls under the overarching field of Internal medicine. His Endocrinology study frequently involves adjacent topics like Cell signaling.
In his study, CRISPR interference, CRISPR, Enhancer, Effector and Transcription activator-like effector nuclease is strongly linked to Computational biology, which falls under the umbrella field of Genetics. His Cell biology research incorporates elements of Tube formation, microRNA, Angiogenesis and Cellular differentiation. His Peroxisome proliferator-activated receptor study integrates concerns from other disciplines, such as Peroxisome, Rosiglitazone, Insulin and Homeostasis.
His main research concerns Internal medicine, Endocrinology, Cell biology, Inflammation and Peroxisome proliferator-activated receptor. His work deals with themes such as Wild type and Cardiology, which intersect with Internal medicine. His study on Endocrinology is mostly dedicated to connecting different topics, such as Downregulation and upregulation.
He has included themes like Embryonic stem cell, Vascular smooth muscle and Cellular differentiation in his Cell biology study. The concepts of his Inflammation study are interwoven with issues in Endothelial stem cell, Cancer research, Cytokine, Transcription factor and Macrophage. His studies in Peroxisome proliferator-activated receptor integrate themes in fields like Peroxisome and Rosiglitazone.
Y. Eugene Chen mainly investigates Internal medicine, Endocrinology, Cholesterol, Cancer research and Computational biology. The various areas that Y. Eugene Chen examines in his Internal medicine study include Minor allele frequency and Cardiology. His Endocrinology study frequently intersects with other fields, such as Nonalcoholic fatty liver disease.
His research in Cancer research intersects with topics in Inflammation, Transcription factor, Telomerase, Telomere and Macrophage. His study looks at the intersection of Transcription factor and topics like IRS1 with TFEB and Cell biology. Y. Eugene Chen combines subjects such as Downregulation and upregulation and Metabolism with his study of Cell biology.
His scientific interests lie mostly in Internal medicine, Vascular smooth muscle, Fatty liver, Adipose tissue and Pathology. The Internal medicine study combines topics in areas such as Phenotype and Endocrinology. His biological study spans a wide range of topics, including Thoracic aortic aneurysm, Cell, Calponin, Autophagy and Pharmacological therapy.
His biological study deals with issues like Bioinformatics, which deal with fields such as Type 2 diabetes. His work investigates the relationship between Adipose tissue and topics such as Mendelian randomization that intersect with problems in Insulin resistance. His Pathology research is multidisciplinary, relying on both Lineage specific, Myocardin, In vitro and Neural crest.
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Exome-wide association study of plasma lipids in > 300,000 individuals
Dajiang J Liu;Gina M Peloso;Gina M Peloso;Haojie Yu;Adam S Butterworth;Adam S Butterworth.
Nature Genetics (2017)
RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency.
Jun Song;Dongshan Yang;Jie Xu;Tianqing Zhu.
Nature Communications (2016)
miR-497 regulates neuronal death in mouse brain after transient focal cerebral ischemia
Ke Jie Yin;Zhen Deng;Huarong Huang;Milton Hamblin.
Neurobiology of Disease (2010)
Loss of Perivascular Adipose Tissue on Peroxisome Proliferator–Activated Receptor-γ Deletion in Smooth Muscle Cells Impairs Intravascular Thermoregulation and Enhances Atherosclerosis
Lin Chang;Luis Villacorta;Rongxia Li;Milton Hamblin.
The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis
Kezhong Zhang;Kezhong Zhang;Shiyu Wang;Jyoti Malhotra;Justin R Hassler.
The EMBO Journal (2011)
Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk
Oddgeir L Holmen;He-Ming Zhang;Yanbo Fan;Daniel H. Hovelson.
Nature Genetics (2014)
Perivascular Adipose Tissue in Vascular Function and Disease: A Review of Current Research and Animal Models
Nicholas K. Brown;Zhou Zhou;Jifeng Zhang;Rong Zeng.
Arteriosclerosis, Thrombosis, and Vascular Biology (2014)
Molecular recognition of nitrated fatty acids by PPAR gamma.
Yong Li;Yong Li;Jifeng Zhang;Francisco J Schopfer;Dariusz Martynowski.
Nature Structural & Molecular Biology (2008)
Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol
Leslie A Lange;Youna Hu;He Zhang;Chenyi Xue.
American Journal of Human Genetics (2014)
Peroxisome proliferator-activated receptor delta regulation of miR-15a in ischemia-induced cerebral vascular endothelial injury.
Ke Jie Yin;Zhen Deng;Zhen Deng;Milton Hamblin;Yi Xiang.
The Journal of Neuroscience (2010)
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