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Genetics

D-Index
56
Citations
37316
World Ranking
3448
National Ranking
1492

Overview

Lars G. Fritsche is affiliated with the University of Michigan-Ann Arbor in the United States. Their research contributions span multiple domains within medicine and biochemistry, genetics, and molecular biology. Fritsche's work frequently addresses genetic associations and epidemiology, retinal imaging and analysis, and COVID-19 clinical research.

Their main fields of study include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Within these broad fields, Fritsche's research delves into specific subfields such as:

  • Genetics
  • Molecular Biology
  • Infectious Diseases
  • Ophthalmology
  • Radiology, Nuclear Medicine and Imaging

Key topics of Fritsche's work cover:

  • Genetic Associations and Epidemiology
  • Retinal Imaging and Analysis
  • COVID-19 Clinical Research Studies
  • Retinal Diseases and Treatments
  • Bioinformatics and Genomic Networks
  • Epigenetics and DNA Methylation
  • COVID-19 and Mental Health

Fritsche has published in several scientific venues, with multiple contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Genetics
  • arXiv (Cornell University)
  • Cell Genomics
  • Nature Communications

Selected recent publications include:

  • "Global Prevalence of Post-Coronavirus Disease 2019 (COVID-19) Condition or Long COVID: A Meta-Analysis and Systematic Review," 2022, The Journal of Infectious Diseases
  • "A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease," 2021, Nature Genetics
  • "Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations," 2021, Cell
  • "Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease," 2022, Cell Genomics
  • "Scalable generalized linear mixed model for region-based association tests in large biobanks and cohorts," 2020, Nature Genetics

Frequent collaborators in their research include:

  • Bhramar Mukherjee
  • Wei Zhou
  • Cristen J. Willer
  • Kristian Hveem
  • Jonas B. Nielsen

Best Publications

  • A global reference for human genetic variation.

    Adam Auton;Gonçalo R. Abecasis;David M. Altshuler;Richard M. Durbin

  • Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies

    Wei Zhou;Jonas B. Nielsen;Lars G. Fritsche;Rounak Dey

  • A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

    Lars G. Fritsche;Wilmar Igl;Jessica N.Cooke Bailey;Felix Grassmann

  • A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease.

    Douglas P Wightman;Iris E Jansen;Jeanne E Savage;Alexey A Shadrin

  • A global reference for human genetic variation

    Adam Auton;Gonçalo R. Abecasis;David M. Altshuler;Richard M. Durbin

  • Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk

    Andrea Rivera;Sheila A. Fisher;Lars G. Fritsche;Claudia N. Keilhauer

  • Seven new loci associated with age-related macular degeneration

    Lars G. Fritsche;Lars G. Fritsche;Wei Chen;Wei Chen;Matthew Schu;Brian L. Yaspan

  • Biobank-driven genomic discovery yields new insight into atrial fibrillation biology

    Jonas B. Nielsen;Rosa B. Thorolfsdottir;Rosa B. Thorolfsdottir;Lars G. Fritsche;Wei Zhou

  • Exome-wide association study of plasma lipids in > 300,000 individuals

    Dajiang J Liu;Gina M Peloso;Gina M Peloso;Haojie Yu;Adam S Butterworth;Adam S Butterworth

  • Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology

    Manuel A. Ferreira;Judith M. Vonk;Hansjörg Baurecht;Ingo Marenholz;Ingo Marenholz

  • Age-Related Macular Degeneration: Genetics and Biology Coming Together

    Lars G. Fritsche;Robert N. Fariss;Dwight Stambolian;Gonçalo R. Abecasis

  • Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA.

    Lars G Fritsche;Thomas Loenhardt;Andreas Janssen;Sheila A Fisher

  • Systemic Complement Activation in Age-Related Macular Degeneration

    Hendrik P N Scholl;Peter Charbel Issa;Maja Walier;Stefanie Janzer

  • Retinal transcriptome and eQTL analyses identify genes associated with age-related macular degeneration

    Rinki Ratnapriya;Olukayode A. Sosina;Olukayode A. Sosina;Margaret R. Starostik;Madeline Kwicklis

  • Defective complement control of Factor H (Y402H) and FHL-1 in age-related macular degeneration

    Christine Skerka;Nadine Lauer;Andreas A W A Weinberger;Claudia N Keilhauer

  • An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD)

    Lars G. Fritsche;Nadine Lauer;Andrea Hartmann;Selina Stippa

  • CRX ChIP-seq reveals the cis-regulatory architecture of mouse photoreceptors

    Joseph C. Corbo;Karen A. Lawrence;Marcus Karlstetter;Connie A. Myers

  • Evidence of a causal relationship between body mass index and psoriasis: A mendelian randomization study

    Ashley Budu-Aggrey;Ben Brumpton;Jess Tyrrell;Jess Tyrrell;Sarah Watkins

  • Scalable generalized linear mixed model for region-based association tests in large biobanks and cohorts.

    Wei Zhou;Zhangchen Zhao;Jonas B. Nielsen;Lars G. Fritsche

  • Exploring and visualizing large-scale genetic associations by using PheWeb

    Sarah A Gagliano Taliun;Peter VandeHaar;Andrew P Boughton;Ryan P Welch

Frequent Co-Authors

Gonçalo R. Abecasis
Gonçalo R. Abecasis University of Michigan–Ann Arbor
Kristian Hveem
Kristian Hveem Norwegian University of Science and Technology
Cristen J. Willer
Cristen J. Willer University of Michigan–Ann Arbor
Bernhard H. F. Weber
Bernhard H. F. Weber University of Regensburg
Anand Swaroop
Anand Swaroop National Institutes of Health
Kari Stefansson
Kari Stefansson deCODE Genetics (Iceland)
Emily Y. Chew
Emily Y. Chew National Institutes of Health
Michael Boehnke
Michael Boehnke University of Michigan–Ann Arbor
Hyun Min Kang
Hyun Min Kang University of Michigan–Ann Arbor
John R.W. Yates
John R.W. Yates University of Cambridge

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