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Biology and Biochemistry

D-Index
69
Citations
17928
World Ranking
7348
National Ranking
3363

Overview

Shey-Shing Sheu is affiliated with Thomas Jefferson University in the United States, specializing primarily in the field of Biochemistry, Genetics and Molecular Biology. Their research encompasses molecular mechanisms related to mitochondrial function and pathology, with significant contributions to understanding ATP synthase and ATPases, cardiac ischemia and reperfusion, metabolism and genetic disorders, ion channel regulation and function, cardiac electrophysiology and arrhythmias, as well as genetic neurodegenerative diseases.

Their recent publications demonstrate a focus on mitochondrial physiology and cardiac cellular mechanisms. Notable papers include:

  • Phosphorylation of cyclophilin D at serine 191 regulates mitochondrial permeability transition pore opening and cell death after ischemia-reperfusion (2020, Cell Death and Disease)
  • Enhanced Mitochondria-SR Tethering Triggers Adaptive Cardiac Muscle Remodeling (2023, Circulation Research)
  • Defective dimerization of FoF1-ATP synthase secondary to glycation favors mitochondrial energy deficiency in cardiomyocytes during aging (2022, Aging Cell)
  • Non-conventional mitochondrial permeability transition: Its regulation by mitochondrial dynamics (2022, Biochimica et Biophysica Acta (BBA) - Bioenergetics)
  • Low intensity magnetic fields stimulate the electron transport chain in heart mitochondria (2022, Biophysical Journal)

They frequently collaborate with researchers such as Yuexing Yuan, Marilén Federico, Zuzana Nichtová, Celia Fernández-Sanz, and Hui-Ying Tsai. These collaborators have coauthored multiple papers with Sheu, indicating ongoing partnerships in subjects related to mitochondrial biology and cardiac physiology.

The main publication venues for their work include:

  • Biophysical Journal
  • Biochimica et Biophysica Acta (BBA) - Bioenergetics
  • Journal of Molecular and Cellular Cardiology
  • Circulation Research
  • Cell Death and Disease

Their research subfields reveal an emphasis on molecular biology with additional expertise in cardiology and cardiovascular medicine, clinical biochemistry, cellular and molecular neuroscience, and pathology and forensic medicine. This multidisciplinary approach supports their investigations into mitochondrial mechanisms and their implications in cardiac and metabolic diseases.

Best Publications

  • Calcium, ATP, and ROS: a mitochondrial love-hate triangle

    Paul S. Brookes;Yisang Yoon;James L. Robotham;M. W. Anders

  • Mitochondrial calcium transport: physiological and pathological relevance

    T. E. Gunter;K. K. Gunter;S. S. Sheu;C. E. Gavin

  • Superoxide Flashes in Single Mitochondria

    Wang Wang;Huaqiang Fang;Linda Groom;Aiwu Cheng

  • Targeting antioxidants to mitochondria: A new therapeutic direction

    Shey-Shing Sheu;Dhananjaya Nauduri;M.W. Anders

  • Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen species.

    Tianzheng Yu;Shey Shing Sheu;James L. Robotham;Yisang Yoon

  • Crosstalk signaling between mitochondrial Ca2+ and ROS.

    Robert F Feissner;Jolanta Skalska;Winston E Gaum;Shey-Shing Sheu

  • The Voltage-Dependent Anion Channel (VDAC): Function in Intracellular Signalling, Cell Life and Cell Death

    V. Shoshan-Barmatz;A. Israelson;D. Brdiczka;S. S. Sheu

  • Transmembrane Na+ and Ca2+ electrochemical gradients in cardiac muscle and their relationship to force development.

    S S Sheu;H A Fozzard

  • Mitochondrial Calcium Uptake from Physiological-type Pulses of Calcium A DESCRIPTION OF THE RAPID UPTAKE MODE

    Genevieve C. Sparagna;Karlene K. Gunter;Shey-Shing Sheu;Thomas E. Gunter

  • Increase in intracellular sodium ion activity during stimulation in mammalian cardiac muscle.

    C J Cohen;H A Fozzard;S S Sheu

  • The Permeability Transition Pore Controls Cardiac Mitochondrial Maturation and Myocyte Differentiation

    Jennifer R. Hom;Rodrigo A. Quintanilla;David L. Hoffman;Karen L. de Mesy Bentley

  • Identification of a Ryanodine Receptor in Rat Heart Mitochondria

    Gisela Beutner;Virendra K. Sharma;David R. Giovannucci;David I. Yule

  • Characteristics and possible functions of mitochondrial Ca(2+) transport mechanisms.

    Thomas E. Gunter;Shey-Shing Sheu

  • Morphological dynamics of mitochondria--a special emphasis on cardiac muscle cells.

    Jennifer Hom;Shey-Shing Sheu

  • Mitochondrial Ca(2+) and regulation of the permeability transition pore.

    Stephen Hurst;Jan Hoek;Shey-Shing Sheu

  • Transport of Ca2+ from Sarcoplasmic Reticulum to Mitochondria in Rat Ventricular Myocytes

    V K Sharma;V Ramesh;C Franzini-Armstrong;S S Sheu

  • Increased Drp1 Acetylation by Lipid Overload Induces Cardiomyocyte Death and Heart Dysfunction

    Qingxun Hu;Huiliang Zhang;Nicolás Gutiérrez Cortés;Dan Wu;Dan Wu

  • Mitochondrial contact sites: their role in energy metabolism and apoptosis.

    Dieter G. Brdiczka;Dmitry B. Zorov;Shey-Shing Sheu

  • Type 1 ryanodine receptor in cardiac mitochondria: transducer of excitation-metabolism coupling.

    Gisela Beutner;Virendra K. Sharma;Lin Lin;Shin-Young Ryu

  • Association of Sorcin With the Cardiac Ryanodine Receptor

    Marian B. Meyers;Virginia M. Pickel;Shey-Shing Sheu;Virendra K. Sharma

Frequent Co-Authors

Robert T. Dirksen
Robert T. Dirksen University of Rochester
Yisang Yoon
Yisang Yoon Augusta University
Paul S. Brookes
Paul S. Brookes University of Rochester Medical Center
Heping Cheng
Heping Cheng Peking University
M. W. Anders
M. W. Anders University of Rochester Medical Center
Toren Finkel
Toren Finkel University of Pittsburgh
Godfrey L. Smith
Godfrey L. Smith University of Glasgow
Robert A. Gross
Robert A. Gross University of Rochester
W. J. Lederer
W. J. Lederer University of Maryland, Baltimore
Feliciano Protasi
Feliciano Protasi University of Chieti-Pescara

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