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D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
34321
World Ranking
8929
National Ranking
37

Overview

Kah-Leong Lim is affiliated with Nanyang Technological University in Singapore and focuses research primarily in the fields of Medicine, Biochemistry, Genetics and Molecular Biology, and Neuroscience. Their work spans several subfields including Neurology, Molecular Biology, Cellular and Molecular Neuroscience, Physiology, and Epidemiology.

The scientist's research covers a range of topics, notably Parkinson's Disease mechanisms and treatments, nuclear receptors and signaling, autophagy in disease and therapy, Alzheimer's disease research and treatments, lipid metabolism and biosynthesis, neuroinflammation and neurodegeneration mechanisms, and neurological diseases and metabolism.

Selected recent papers authored or coauthored by Kah-Leong Lim include:

  • Ultrafast Detection of Peroxynitrite in Parkinson's Disease Models Using a Near-Infrared Fluorescent Probe, 2020, Analytical Chemistry
  • Lysosomal acidification dysfunction in microglia: an emerging pathogenic mechanism of neuroinflammation and neurodegeneration, 2023, Journal of Neuroinflammation
  • A Flexi-PEGDA Upconversion Implant for Wireless Brain Photodynamic Therapy, 2020, Advanced Materials
  • Mitochondria targeting drugs for neurodegenerative diseases-Design, mechanism and application, 2022, Acta Pharmaceutica Sinica B
  • PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function, 2020, Nature Chemical Biology

Frequent collaborators in their research include Chengwu Zhang, Lin Li, Christopher Chen, Chou Chai, and Yee Jie Yeap.

Publications by Kah-Leong Lim appear repeatedly in venues such as bioRxiv (Cold Spring Harbor Laboratory), International Journal of Molecular Sciences, NeuroMolecular Medicine, SSRN Electronic Journal, and Advanced Materials.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

    Daniel J. Klionsky;Hagai Abeliovich;Patrizia Agostinis;Devendra K. Agrawal

  • Parkin ubiquitinates the α-synuclein–interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

    Kenny K.K. Chung;Yi Zhang;Kah Leong Lim;Yuji Tanaka

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

    Andrew B. West;Darren J. Moore;Catherine Choi;Shaida A. Andrabi

  • Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1 : implications for Lewy body formation

    Kah Leong Lim;Katherine C. M. Chew;Jeanne M. M. Tan;Cheng Wang

  • Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

    Joo-Yong Lee;Yoshito Nagano;J. Paul Taylor;Kah Leong Lim

  • Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases

    Jeanne M M Tan;Esther S P Wong;Donald S. Kirkpatrick;Olga Pletnikova

  • Loss of locus coeruleus neurons and reduced startle in parkin null mice

    Rainer von Coelln;Bobby Thomas;Joseph M. Savitt;Kah Leong Lim

  • Intraparticle Energy Level Alignment of Semiconducting Polymer Nanoparticles to Amplify Chemiluminescence for Ultrasensitive In Vivo Imaging of Reactive Oxygen Species.

    Xu Zhen;Chengwu Zhang;Chen Xie;Qingqing Miao

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Targeted disruption of the tyrosine phosphatase PTPα leads to constitutive downregulation of the kinases Src and Fyn

    Sathivel Ponniah;Dennis Z.M. Wang;Kah Leong Lim;Catherine J. Pallen

  • Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin

    Sathya R. Sriram;Xiaojie Li;Han Seok Ko;Kenny K.K. Chung

  • Parkin Protects against LRRK2 G2019S Mutant-Induced Dopaminergic Neurodegeneration in Drosophila

    Chee Hoe Ng;Shaun Z.S. Mok;Cherlyn Koh;Xuezhi Ouyang

  • Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function

    Cheng Wang;Han Seok Ko;Bobby Thomas;Fai Tsang

  • A sensitive two-photon probe to selectively detect monoamine oxidase B activity in Parkinson’s disease models

    Lin Li;Cheng-Wu Zhang;Grace Y. J. Chen;Biwei Zhu

  • Reactive oxygen species trigger Parkin/PINK1 pathway-dependent mitophagy by inducing mitochondrial recruitment of Parkin.

    Bin Xiao;Jian-Yuan Goh;Lin Xiao;Hongxu Xian

  • Autophagy-mediated clearance of aggresomes is not a universal phenomenon

    Esther S.P. Wong;Jeanne M.M. Tan;Wen E. Soong;Kamila Hussein

  • AMP kinase activation mitigates dopaminergic dysfunction and mitochondrial abnormalities in Drosophila models of Parkinson's disease.

    Chee-Hoe Ng;Melissa S. H. Guan;Cherlyn Koh;Xuezhi Ouyang

Frequent Co-Authors

Ted M. Dawson
Ted M. Dawson Johns Hopkins University School of Medicine
Eng-King Tan
Eng-King Tan National University of Singapore
Valina L. Dawson
Valina L. Dawson Johns Hopkins University School of Medicine
Wei Huang
Wei Huang Northwestern Polytechnical University
Catherine J. Pallen
Catherine J. Pallen University of British Columbia
Tso-Pang Yao
Tso-Pang Yao Duke University
Evelina Gatti
Evelina Gatti Aix-Marseille University
Han-Ming Shen
Han-Ming Shen University of Macau
Beth Levine
Beth Levine The University of Texas Southwestern Medical Center
Sergio Lavandero
Sergio Lavandero University of Chile

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