What is he best known for?
The fields of study he is best known for:
His primary scientific interests are in Cancer research, Apoptosis, Programmed cell death, Cancer and Caspase.
His Cancer research research includes elements of Cell culture, Protein kinase B, Pathology, Stem cell and PTEN.
His study looks at the relationship between Apoptosis and fields such as Cancer cell, as well as how they intersect with chemical problems.
Frank A.E. Kruyt studies Inhibitor of apoptosis, a branch of Programmed cell death.
His Cancer research incorporates themes from Lung cancer, Chemotherapy and Immunology.
His study in Caspase is interdisciplinary in nature, drawing from both Calpain and Cell biology.
His most cited work include:
- Cell Death Independent of Caspases: A Review (757 citations)
- Expression cloning of a cDNA for the major Fanconi anaemia gene, FAA (388 citations)
- Response to epidermal growth factor receptor inhibitors in non-small cell lung cancer cells: Limited antiproliferative effects and absence of apoptosis associated with persistent activity of extracellular signal-regulated kinase or Akt kinase pathways (304 citations)
What are the main themes of his work throughout his whole career to date?
His main research concerns Cancer research, Apoptosis, Molecular biology, Cell biology and Cell culture.
Frank A.E. Kruyt has included themes like Cisplatin, Cancer cell, Cancer stem cell, Stem cell and Lung cancer in his Cancer research study.
His Lung cancer research is multidisciplinary, incorporating perspectives in Cancer, Chemotherapy and Bortezomib.
His work on Downregulation and upregulation expands to the thematically related Apoptosis.
His study focuses on the intersection of Molecular biology and fields such as Fanconi anemia, complementation group C with connections in the field of FANCF and FANCG.
He has researched Programmed cell death in several fields, including Autophagy and Cytotoxicity.
He most often published in these fields:
- Cancer research (49.39%)
- Apoptosis (28.66%)
- Molecular biology (18.90%)
What were the highlights of his more recent work (between 2013-2021)?
- Cancer research (49.39%)
- Cell culture (16.46%)
- Pathology (7.93%)
In recent papers he was focusing on the following fields of study:
Cancer research, Cell culture, Pathology, Internal medicine and Mesenchymal stem cell are his primary areas of study.
His Cancer research research is multidisciplinary, relying on both Epithelial–mesenchymal transition and Cancer stem cell, Stem cell.
Frank A.E. Kruyt combines subjects such as Cell growth, Molecular biology, Flow cytometry and Receptor, Growth factor with his study of Cell culture.
His studies in Internal medicine integrate themes in fields like Gastroenterology and Oncology.
His research investigates the connection between Mesenchymal stem cell and topics such as Angiogenesis that intersect with problems in Vascular endothelial growth factor A.
His work on Programmed cell death as part of general Apoptosis study is frequently linked to SK channel, therefore connecting diverse disciplines of science.
Between 2013 and 2021, his most popular works were:
- Hypoxia enhances migration and invasion in glioblastoma by promoting a mesenchymal shift mediated by the HIF1α-ZEB1 axis (160 citations)
- TGF-β is an inducer of ZEB1-dependent mesenchymal transdifferentiation in glioblastoma that is associated with tumor invasion (85 citations)
- EMT‐ and MET‐related processes in nonepithelial tumors: importance for disease progression, prognosis, and therapeutic opportunities (59 citations)
In his most recent research, the most cited papers focused on:
His primary areas of investigation include Cancer research, Epithelial–mesenchymal transition, Cancer stem cell, Pathology and Stem cell.
His studies deal with areas such as Immunohistochemistry, Molecular pathology, Gene expression, Tumor microenvironment and Mesenchymal stem cell as well as Cancer research.
His Epithelial–mesenchymal transition research incorporates elements of Breast cancer and Transdifferentiation.
His Cancer stem cell research is multidisciplinary, incorporating elements of Lung cancer and CD44.
His research integrates issues of Gene expression profiling, Transcriptome, Subclass, Regulation of gene expression and PTEN in his study of Pathology.
While the research belongs to areas of Stem cell, he spends his time largely on the problem of Cell culture, intersecting his research to questions surrounding Transcription factor and Hypoxia.
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