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D-Index & Metrics

Biology and Biochemistry

D-Index
61
Citations
12419
World Ranking
11421
National Ranking
296

Overview

Frank A.E. Kruyt is affiliated with the University Medical Center Groningen in the Netherlands. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on several subfields including Cell Biology, Molecular Biology, Epidemiology, Oncology, and Biomedical Engineering.

The scientist's recent publications cover diverse topics related to cancer biology and treatment strategies. Notable papers include:

  • TGF-β promotes microtube formation in glioblastoma through thrombospondin 1, 2021, Neuro-Oncology
  • The unfolded protein response as regulator of cancer stemness and differentiation: Mechanisms and implications for cancer therapy, 2021, Biochemical Pharmacology
  • Physics of Brain Cancer: Multiscale Alterations of Glioblastoma Cells under Extracellular Matrix Stiffening, 2022, Pharmaceutics
  • Bioinspired Processing: Complex Coacervates as Versatile Inks for 3D Bioprinting, 2023, Advanced Materials
  • Three-dimensional culture models to study glioblastoma - current trends and future perspectives, 2021, Current Opinion in Pharmacology

Frequent coauthors include:

  • Liang Dong
  • Mohammad Khoonkari
  • Wilfred F.A. den Dunnen
  • Schelto Kruijff
  • Rob J. M. Groen

Common publication venues for their work are:

  • Neuro-Oncology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biochemical Pharmacology
  • International Journal of Molecular Sciences
  • Journal of Neurosurgery

The main research topics addressed in their work include:

  • Cellular Mechanics and Interactions
  • Meningioma and schwannoma management
  • Glioma Diagnosis and Treatment
  • Microtubule and mitosis dynamics
  • Cell death mechanisms and regulation
  • Nanoplatforms for cancer theranostics
  • Cancer-related Molecular Pathways

Frank A.E. Kruyt's research integrates multiple aspects of cancer biology, particularly related to glioblastoma and brain cancer. Their work also explores molecular pathways, cancer stemness, and innovative technological approaches such as 3D bioprinting. The scientist's contributions are positioned within a multidisciplinary framework involving cellular and molecular biology, cancer treatment, and bioengineering methodologies.

Best Publications

  • Cell Death Independent of Caspases: A Review

    Linda E. Bröker;Frank A.E. Kruyt;Giuseppe Giaccone

  • Expression cloning of a cDNA for the major Fanconi anaemia gene, FAA

    J R Foe;M A Rooimans;L Bosnoyan-Collins;N Alon

  • Response to epidermal growth factor receptor inhibitors in non-small cell lung cancer cells: Limited antiproliferative effects and absence of apoptosis associated with persistent activity of extracellular signal-regulated kinase or Akt kinase pathways

    Maarten L Janmaat;Frank A E Kruyt;José A Rodriguez;Giuseppe Giaccone

  • Apoptosis: Target of cancer therapy

    Carlos G Ferreira;Mirjam Epping;Frank A E Kruyt;Giuseppe Giaccone

  • Global Histone Modifications Predict Prognosis of Resected Non–Small-Cell Lung Cancer

    Fabrice Barlési;Giuseppe Giaccone;Marielle I. Gallegos-Ruiz;Anderson Loundou

  • Hypoxia enhances migration and invasion in glioblastoma by promoting a mesenchymal shift mediated by the HIF1α-ZEB1 axis

    Justin Vareecal Joseph;Siobhan Conroy;Kirill Pavlov;Pallavi Sontakke

  • Cathepsin B mediates caspase-independent cell death induced by microtubule stabilizing agents in non-small cell lung cancer cells.

    Linda E. Bröker;Cynthia Huisman;Simone W. Span;José A. Rodriguez

  • Chemotherapy triggers apoptosis in a caspase-8-dependent and mitochondria-controlled manner in the non-small cell lung cancer cell line NCI-H460.

    Carlos G. Ferreira;Simone W. Span;Godefridus J. Peters;Frank A. E. Kruyt

  • Circulating tumor cells in small-cell lung cancer: a predictive and prognostic factor

    T.J.N. Hiltermann;M.M. Pore;A. van den Berg;W. Timens

  • The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG

    Johan P. de Winter;Laura van der Weel;Jan de Groot;Stacie Stone

  • CRM1-mediated nuclear export determines the cytoplasmic localization of the antiapoptotic protein Survivin

    Jose A. Rodríguez;Simone W. Span;Carlos G.M. Ferreira;Frank A.E. Kruyt

  • TRAIL and cancer therapy

    Frank A.E. Kruyt

  • Playing the DISC: Turning on TRAIL death receptor-mediated apoptosis in cancer

    Bodvael Pennarun;Annemieke Meijer;Elisabeth G E de Vries;Jan H Kleibeuker

  • Non-canonical kinase signaling by the death ligand TRAIL in cancer cells: discord in the death receptor family.

    K Azijli;B Weyhenmeyer;G J Peters;S de Jong

  • TGF-β is an inducer of ZEB1-dependent mesenchymal transdifferentiation in glioblastoma that is associated with tumor invasion

    J V Joseph;S Conroy;T Tomar;E Eggens-Meijer

  • TGF-β as a therapeutic target in high grade gliomas - promises and challenges.

    Justin V. Joseph;Veerakumar Balasubramaniyan;Annemiek Walenkamp;Frank A.E. Kruyt

  • Abnormal Microsomal Detoxification Implicated in Fanconi Anemia Group C by Interaction of the FAC Protein With NADPH Cytochrome P450 Reductase

    Frank A.E. Kruyt;Taizo Hoshino;Taizo Hoshino;Johnson M. Liu;Johnson M. Liu;Pius Joseph;Pius Joseph

  • Enhanced cytotoxicity induced by gefitinib and specific inhibitors of the Ras or phosphatidyl inositol‐3 kinase pathways in non‐small cell lung cancer cells

    Maarten L. Janmaat;José A. Rodriguez;Mariëlle Gallegos-Ruiz;Frank A.E. Kruyt

  • A physical complex of the Fanconi anemia proteins FANCG/XRCC9 and FANCA

    Q. Waisfisz;J. P. De Winter;F. A. E. Kruyt;J. De Groot

  • TRAIL therapy in non–small cell lung cancer cells: sensitization to death receptor–mediated apoptosis by proteasome inhibitor bortezomib

    Jens Voortman;Tatiana P. Resende;Mohamed A.I. Abou El Hassan;Giuseppe Giaccone

Frequent Co-Authors

Godefridus J. Peters
Godefridus J. Peters Gdańsk Medical University
Giuseppe Giaccone
Giuseppe Giaccone Cornell University
Fré Arwert
Fré Arwert VU University Medical Center
Wim J. Quax
Wim J. Quax University of Groningen
Jan H. Kleibeuker
Jan H. Kleibeuker University Medical Center Groningen
Hans Joenje
Hans Joenje VU University Medical Center
Manuel Buchwald
Manuel Buchwald University of Toronto
Gerrit Jansen
Gerrit Jansen Amsterdam UMC
Anke van den Berg
Anke van den Berg University Medical Center Groningen
Henk L. Dekker
Henk L. Dekker University of Amsterdam

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