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Biology and Biochemistry

D-Index
55
Citations
8755
World Ranking
15253
National Ranking
370

Overview

Jan Jacob Schuringa is affiliated with the University Medical Center Groningen in the Netherlands. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on subfields such as Molecular Biology, Hematology, Immunology, Genetics, and Cancer Research.

Their main research topics include:

  • Acute Myeloid Leukemia Research
  • Immune cells in cancer
  • Histone Deacetylase Inhibitors Research
  • Protein Degradation and Inhibitors
  • Epigenetics and DNA Methylation
  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Retinoids in leukemia and cellular processes

Jan Jacob Schuringa has published extensively, contributing frequently to the following journals and venues:

  • Blood
  • HemaSphere
  • Blood Advances
  • Experimental Hematology
  • bioRxiv (Cold Spring Harbor Laboratory)

Some of their recent publications include:

  • Innovations, challenges, and minimal information for standardization of humanized mice, 2020, EMBO Molecular Medicine
  • Prevalence, predictors, and outcomes of clonal hematopoiesis in individuals aged ≥80 years, 2021, Blood Advances
  • Evolutionary landscape of clonal hematopoiesis in 3,359 individuals from the general population, 2023, Cancer Cell
  • Erythrocytosis in the general population: clinical characteristics and association with clonal hematopoiesis, 2020, Blood Advances
  • The Glycolytic Gatekeeper PDK1 defines different metabolic states between genetically distinct subtypes of human acute myeloid leukemia, 2022, Nature Communications

Frequent collaborators in their work include:

  • Diego A. Pereira-Martins
  • Gerwin Huls
  • Eduardo Magalhães Rego
  • Isabel Weinhäuser
  • Emanuele Ammatuna

Best Publications

  • Cancer stem cell definitions and terminology: the devil is in the details

    Peter Valent;Dominique Bonnet;Ruggero De Maria;Tsvee Lapidot

  • Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from IL-10.

    Diane Lejeune;Laure Dumoutier;Stefan Constantinescu;Wiebe Kruijer

  • Constitutive Stat3, Tyr705, and Ser727 phosphorylation in acute myeloid leukemia cells caused by the autocrine secretion of interleukin-6

    Jan-Jacob Schuringa;Albertus T. J. Wierenga;Wiebe Kruijer;Edo Vellenga

  • Repression of BMI1 in normal and leukemic human CD34+ cells impairs self-renewal and induces apoptosis

    Aleksandra Rizo;Sandra Olthof;Lina Han;Edo Vellenga

  • Signaling pathways in self-renewing hematopoietic and leukemic stem cells: do all stem cells need a niche?

    Aleksandra Rizo;Edo Vellenga;Gerald de Haan;Jan Jacob Schuringa

  • Constitutive activation of STAT5A promotes human hematopoietic stem cell self-renewal and erythroid differentiation.

    Jan Jacob Schuringa;Ki Young Chung;Giovanni Morrone;Malcolm A.S. Moore

  • Ser727-dependent transcriptional activation by association of p300 with STAT3 upon IL-6 stimulation.

    Jan-Jacob Schuringa;Hein Schepers;Edo Vellenga;Wiebe Kruijer

  • Reconstructing the human hematopoietic niche in immunodeficient mice: opportunities for studying primary multiple myeloma.

    Richard W. J. Groen;Willy A. Noort;Reinier A. Raymakers;Henk-Jan Prins

  • Non-canonical PRC1.1 Targets Active Genes Independent of H3K27me3 and Is Essential for Leukemogenesis

    Vincent van den Boom;Henny Maat;Marjan Geugien;Aida Rodríguez López

  • Long-term maintenance of human hematopoietic stem/progenitor cells by expression of BMI1.

    Aleksandra Rizo;Bert Dontje;Edo Vellenga;Gerald de Haan

  • Interleukin-6-induced STAT3 transactivation and Ser727 phosphorylation involves Vav, Rac-1 and the kinase SEK-1/MKK-4 as signal transduction components.

    Jan-Jacob Schuringa;Luigi J. C. Jonk;Wim H. A. Dokter;Edo Vellenga

  • Gene expression profiling in the leukemic stem cell-enriched CD34+ fraction identifies target genes that predict prognosis in normal karyotype AML

    H J M de Jonge;C M Woolthuis;A Z Vos;A Mulder

  • MEN2A-RET-induced cellular transformation by activation of STAT3

    Jan Jacob Schuringa;Katarzyna Wojtachnio;Werner Hagens;Edo Vellenga

  • STAT5 is required for long-term maintenance of normal and leukemic human stem/progenitor cells.

    Hein Schepers;Hein Schepers;Djoke van Gosliga;Albertus T. J. Wierenga;Bart J. L. Eggen

  • Bone marrow dysfunction in chronic heart failure patients

    B. Daan Westenbrink;Adriaan A. Voors;Rudolf A. de Boer;Jan J. Schuringa

  • Sequential Activation of Rac-1, SEK-1/MKK-4, and Protein Kinase Cδ Is Required for Interleukin-6-induced STAT3 Ser-727 Phosphorylation and Transactivation

    Jan-Jacob Schuringa;Lodewijk V. Dekker;Edo Vellenga;Wiebe Kruijer

  • Apoptosis and cancer stem cells: Implications for apoptosis targeted therapy

    Frank A. E. Kruyt;Jan Jacob Schuringa

  • Establishing long-term cultures with self-renewing acute myeloid leukemia stem/progenitor cells

    Djoke van Gosliga;Hein Schepers;Aleksandra Rizo;Dorina van der Kolk

  • Maximal STAT5-induced proliferation and self-renewal at intermediate STAT5 activity levels

    Albertus T. J. Wierenga;Edo Vellenga;Jan Jacob Schuringa

  • A Proteomics and Transcriptomics Approach to Identify Leukemic Stem Cell (LSC) Markers

    Francesco Bonardi;Fabrizia Fusetti;Patrick Deelen;Djoke van Gosliga

Frequent Co-Authors

Edo Vellenga
Edo Vellenga University Medical Center Groningen
Malcolm A.S. Moore
Malcolm A.S. Moore Memorial Sloan Kettering Cancer Center
Joost H.A. Martens
Joost H.A. Martens Radboud University
Gerald de Haan
Gerald de Haan University Medical Center Groningen
Bart J. L. Eggen
Bart J. L. Eggen University Medical Center Groningen
Wim J. Quax
Wim J. Quax University of Groningen
Paul J. Coffer
Paul J. Coffer Utrecht University
Peter J. M. Valk
Peter J. M. Valk Erasmus University Rotterdam
Pim van der Harst
Pim van der Harst University Medical Center Utrecht
Tuna Mutis
Tuna Mutis Vrije Universiteit Amsterdam

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