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Overview

Gregory P. Downey is affiliated with National Jewish Health in the United States. Their research primarily focuses on Medicine, with extensive work in Pulmonary and Respiratory Medicine, Infectious Diseases, Health, Toxicology and Mutagenesis, Molecular Biology, and Physiology.

The main topics addressed in their research include:

  • Air Quality and Health Impacts
  • SARS-CoV-2 and COVID-19 Research
  • Respiratory Support and Mechanisms
  • COVID-19 Clinical Research Studies
  • Climate Change and Health Impacts
  • Tuberous Sclerosis Complex Research
  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Downey has contributed to various publication venues, most notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • American Journal of Respiratory and Critical Care Medicine
  • American Journal of Respiratory Cell and Molecular Biology
  • European Respiratory Journal
  • CHEST Journal

Significant recent papers by Downey include:

  • Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report, 2022, American Journal of Respiratory Cell and Molecular Biology
  • The basis of a more contagious 501Y.V1 variant of SARS-CoV-2, 2021, Cell Research
  • Saracatinib, a Selective Src Kinase Inhibitor, Blocks Fibrotic Responses in Preclinical Models of Pulmonary Fibrosis, 2022, American Journal of Respiratory and Critical Care Medicine
  • 501Y.V2 and 501Y.V3 variants of SARS-CoV-2 lose binding to bamlanivimab in vitro, 2021, mAbs
  • Influenza virus infection increases ACE2 expression and shedding in human small airway epithelial cells, 2021, European Respiratory Journal

Frequent co-authors working alongside Downey include:

  • Hong Wei Chu
  • Kelly A. Correll
  • Yael Aschner
  • Haolin Liu
  • Qianqian Zhang

Overall, Downey's contributions span fundamental and applied research in pulmonary diseases and infectious pathogens, highlighting ongoing investigations into the biological mechanisms underlying respiratory conditions and emerging viral variants.

Best Publications

  • An Official American Thoracic Society Workshop Report: Features and Measurements of Experimental Acute Lung Injury in Animals

    Gustavo Matute-Bello;Gregory Downey;Bethany B. Moore;Steve D. Groshong

  • Efficacy and safety of sirolimus in lymphangioleiomyomatosis.

    Francis X. McCormack;Yoshikazu Inoue;Joel Moss;Lianne G. Singer

  • Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function

    Lea Fialkow;Yingchun Wang;Gregory P. Downey

  • Mechanics of stimulated neutrophils: cell stiffening induces retention in capillaries

    GS Worthen;B Schwab;EL Elson;GP Downey

  • Neutrophil activation and acute lung injury.

    Warren L. Lee;Gregory P. Downey

  • Leukocyte elastase: physiological functions and role in acute lung injury.

    Warren L. Lee;Gregory P. Downey

  • Oxidative stress and acute lung injury.

    Chung-Wai Chow;Maria Teresa Herrera Abreu;Tomoko Suzuki;Gregory P. Downey

  • The remote ischemic preconditioning stimulus modifies inflammatory gene expression in humans

    Igor E. Konstantinov;Sara Arab;Rajesh K. Kharbanda;Jia Li

  • Transepithelial migration of neutrophils: mechanisms and implications for acute lung injury.

    Rachel L. Zemans;Sean P. Colgan;Gregory P. Downey;Gregory P. Downey

  • Rac1 Deletion in Mouse Neutrophils Has Selective Effects on Neutrophil Functions

    Michael Glogauer;Christophe C. Marchal;Fei Zhu;Aelaf Worku

  • The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance

    Ellen L Burnham;William J Janssen;David W H Riches;Marc Moss

  • The Role of Actin-binding Protein 280 in Integrin-dependent Mechanoprotection

    Michael Glogauer;Pam Arora;Deborah Chou;Paul A. Janmey

  • Rapidly progressive bronchiolitis obliterans with organizing pneumonia.

    Andrea J. Cohen;Talmadge E. King;Gregory P. Downey

  • Official American Thoracic Society/Japanese Respiratory Society Clinical Practice Guidelines: Lymphangioleiomyomatosis Diagnosis and Management

    Francis X. McCormack;Nishant Gupta;Geraldine R. Finlay;Lisa R. Young

  • Cystic Fibrosis Mouse Models

    Claudine Guilbault;Zienab Saeed;Gregory P. Downey;Danuta Radzioch

  • Neutrophil granule contents in the pathogenesis of lung injury.

    Theo J Moraes;Joanna H Zurawska;Gregory P Downey

  • An SH3 binding region in the epithelial Na+ channel (alpha rENaC) mediates its localization at the apical membrane.

    D Rotin;D Bar-Sagi;H O'Brodovich;J Merilainen

  • Proteases and lung injury.

    Theo J. Moraes;Chung-Wai Chow;Gregory P. Downey

  • Retention of leukocytes in capillaries: role of cell size and deformability.

    G. P. Downey;D. E. Doherty;B. Schwab;E. L. Elson

  • Activation of the mitogen-activated protein kinase signaling pathway in neutrophils. Role of oxidants.

    L. Fialkow;Chi Kin Chan;D. Rotin;S. Grinstein

Frequent Co-Authors

Christopher A. McCulloch
Christopher A. McCulloch University of Toronto
Thomas K. Waddell
Thomas K. Waddell University Health Network
Peter M. Henson
Peter M. Henson National Jewish Health
Katherine A. Siminovitch
Katherine A. Siminovitch Lunenfeld-Tanenbaum Research Institute
Michael Glogauer
Michael Glogauer University of Toronto
Francis X. McCormack
Francis X. McCormack University of Cincinnati
David W. H. Riches
David W. H. Riches University of Colorado Denver
Elliot L. Elson
Elliot L. Elson Washington University in St. Louis
Bruce C. Trapnell
Bruce C. Trapnell Cincinnati Children's Hospital Medical Center
Kevin K. Brown
Kevin K. Brown National Jewish Health

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