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Biology and Biochemistry

D-Index
60
Citations
16011
World Ranking
11793
National Ranking
5071

Overview

David W. H. Riches is affiliated with the University of Colorado Denver in the United States. Their research primarily focuses on the field of Medicine, with a strong specialization in Pulmonary and Respiratory Medicine. Other subfields of study include Molecular Biology, Surgery, Biomaterials, and Electrical and Electronic Engineering.

The scientist's work extensively covers topics related to pulmonary conditions and respiratory health. The main topics of their research include:

  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Inhalation and Respiratory Drug Delivery
  • Neonatal Respiratory Health Research
  • Medical Imaging and Pathology Studies
  • Tissue Engineering and Regenerative Medicine
  • Occupational and environmental lung diseases
  • Fibroblast Growth Factor Research

David W. H. Riches has contributed to multiple peer-reviewed papers. Recent publications include:

  • "Regulation of epithelial transitional states in murine and human pulmonary fibrosis," 2023, Journal of Clinical Investigation
  • "Persistent, Progressive Pulmonary Fibrosis and Epithelial Remodeling in Mice," 2021, American Journal of Respiratory Cell and Molecular Biology
  • "Inhibition of antiapoptotic BCL-2 proteins with ABT-263 induces fibroblast apoptosis, reversing persistent pulmonary fibrosis," 2023, JCI Insight
  • "Loss of Fas signaling in fibroblasts impairs homeostatic fibrosis resolution and promotes persistent pulmonary fibrosis," 2020, JCI Insight
  • "Engineering Hybrid-Hydrogels Comprised of Healthy or Diseased Decellularized Extracellular Matrix to Study Pulmonary Fibrosis," 2022, Cellular and Molecular Bioengineering

Their frequent co-authors include:

  • Elizabeth F. Redente
  • Rachel L. Zemans
  • Rachel Blomberg
  • Chelsea M. Magin
  • Benjamin Edelman

David W. H. Riches has been published multiple times in various venues, with frequent contributions to:

  • Journal of Clinical Investigation
  • American Journal of Respiratory Cell and Molecular Biology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • JCI Insight
  • American Journal of Respiratory and Critical Care Medicine

Best Publications

  • Early Pulmonary Inflammation in Infants with Cystic Fibrosis

    Talat Z. Khan;Jeffrey S. Wagener;Thomas Bost;Jose Martinez

  • Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes.

    Sergey Nejentsev;Neil Walker;David Riches;Michael Egholm

  • Vitamin D Inhibits Monocyte/Macrophage Proinflammatory Cytokine Production by Targeting MAPK Phosphatase-1

    Yong Zhang;Donald Y. M. Leung;Brittany N. Richers;Yusen Liu;Yusen Liu

  • Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs

    Donald G. Phinney;Michelangelo Di Giuseppe;Joel Njah;Ernest Sala

  • Minimal Differentiation of Classical Monocytes as They Survey Steady-State Tissues and Transport Antigen to Lymph Nodes

    Claudia Jakubzick;Claudia Jakubzick;Emmanuel L. Gautier;Sophie L. Gibbings;Dorothy K. Sojka

  • Hyaluronate activation of CD44 induces insulin-like growth factor-1 expression by a tumor necrosis factor-alpha-dependent mechanism in murine macrophages.

    P. W. Noble;F. R. Lake;P. M. Henson;D. W. H. Riches

  • IFN-gamma + LPS induction of iNOS is modulated by ERK, JNK/SAPK, and p38(mapk) in a mouse macrophage cell line.

    Edward D. Chan;David W. H. Riches

  • The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance

    Ellen L Burnham;William J Janssen;David W H Riches;Marc Moss

  • ERK-mediated phosphorylation of Thr735 in TNFα-converting enzyme and its potential role in TACE protein trafficking

    Surinder M. Soond;Bethany Everson;David W. H. Riches;Gillian Murphy

  • Increased expression of the interleukin-8 gene by alveolar macrophages in idiopathic pulmonary fibrosis. A potential mechanism for the recruitment and activation of neutrophils in lung fibrosis.

    P C Carré;R L Mortenson;T E King;P W Noble

  • Matrix metalloproteinase 3 is a mediator of pulmonary fibrosis.

    Cory M. Yamashita;Lior Dolgonos;Rachel L. Zemans;Scott K. Young

  • Autophagy variation within a cell population determines cell fate through selective degradation of Fap-1

    Jacob M. Gump;Leah Staskiewicz;Michael J. Morgan;Alison Bamberg

  • Tumor Necrosis Factor-α Accelerates the Resolution of Established Pulmonary Fibrosis in Mice by Targeting Profibrotic Lung Macrophages

    Elizabeth F. Redente;Rebecca C. Keith;William Janssen;Peter M. Henson

  • Corticosteroid-resistant asthma is associated with classical antimicrobial activation of airway macrophages.

    Elena Goleva;Pia J. Hauk;Clifton F. Hall;Andrew H. Liu

  • Potential of Nintedanib in Treatment of Progressive Fibrosing Interstitial Lung Diseases

    Lutz Wollin;Jörg H.W. Distler;Elizabeth F. Redente;David W.H. Riches

  • Tumor necrosis factor alpha rapidly activates the mitogen-activated protein kinase (MAPK) cascade in a MAPK kinase kinase-dependent, c-Raf-1-independent fashion in mouse macrophages.

    Brent W. Winston;Carol A. Lange-Carter;Anne M. Gardner;Gary L. Johnson

  • Particle digestibility is required for induction of the phosphatidylserine recognition mechanism used by murine macrophages to phagocytose apoptotic cells.

    V. A. Fadok;D. J. Laszlo;P. W. Noble;L. Weinstein

  • Induction of inducible nitric oxide synthase-NO* by lipoarabinomannan of Mycobacterium tuberculosis is mediated by MEK1-ERK, MKK7-JNK, and NF-kappaB signaling pathways.

    Edward D. Chan;Kristin R. Morris;John T. Belisle;Preston Hill

  • Age and sex dimorphisms contribute to the severity of bleomycin-induced lung injury and fibrosis

    Elizabeth F. Redente;Kristen M. Jacobsen;Joshua J. Solomon;Abigail R. Lara

  • Evaluation of the role of mitogen-activated protein kinases in the expression of inducible nitric oxide synthase by IFN-gamma and TNF-alpha in mouse macrophages.

    Edward D. Chan;Brent W. Winston;Soo-Taek Uh;Murry W. Wynes

Frequent Co-Authors

Peter M. Henson
Peter M. Henson National Jewish Health
Edward D. Chan
Edward D. Chan National Jewish Health
Paul W. Noble
Paul W. Noble Cedars-Sinai Medical Center
Donna L. Bratton
Donna L. Bratton University of Colorado Anschutz Medical Campus
Gregory P. Downey
Gregory P. Downey National Jewish Health
Donald Y.M. Leung
Donald Y.M. Leung National Jewish Health
Gary L. Johnson
Gary L. Johnson University of North Carolina at Chapel Hill
Carlyne D. Cool
Carlyne D. Cool University of Colorado Denver
Valerie A. Fadok
Valerie A. Fadok Zoetis (United States)
Rubin M. Tuder
Rubin M. Tuder University of Colorado Denver

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