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Biology and Biochemistry

D-Index
61
Citations
9925
World Ranking
11610
National Ranking
4995

Overview

John Svaren is affiliated with the University of Wisconsin-Madison in the United States. Their research primarily spans the fields of Neuroscience and Biochemistry, Genetics and Molecular Biology, with significant contributions to subfields such as Molecular Biology, Cellular and Molecular Neuroscience, Neurology, Developmental Neuroscience, and Cell Biology.

Their scientific work addresses a range of topics including:

  • Hereditary Neurological Disorders
  • Nerve injury and regeneration
  • Neurogenesis and neuroplasticity mechanisms
  • Peripheral Neuropathies and Disorders
  • Neurological diseases and metabolism
  • Single-cell and spatial transcriptomics
  • Signaling Pathways in Disease

Frequent publication venues where Svaren's work has appeared include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Brain
  • Glia
  • Journal of Neuroscience
  • Human Molecular Genetics

Recent published papers authored or co-authored by Svaren include:

  • "Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun," 2021, eLife
  • "CTCF loss mediates unique DNA hypermethylation landscapes in human cancers," 2020, Clinical Epigenetics
  • "MicroRNAs as Biomarkers of Charcot-Marie-Tooth Disease Type 1A," 2021, Neurology
  • "JUN Regulation of Injury-Induced Enhancers in Schwann Cells," 2022, Journal of Neuroscience
  • "Neurofilament light plasma concentration positively associates with age and negatively associates with weight and height in the dog," 2020, Neuroscience Letters

John Svaren has collaborated frequently with several researchers, often working together on multiple projects. Notable frequent co-authors include:

  • Raghu Ramesh
  • Seongsik Won
  • Ki H.
  • John J. Moran
  • Daifeng Wang

Best Publications

  • Fluoro ketone inhibitors of hydrolytic enzymes.

    Michael H. Gelb;John P. Svaren;Robert H. Abeles

  • NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli.

    J Svaren;B R Sevetson;E D Apel;D B Zimonjic

  • Associations Between Early Life Stress and Gene Methylation in Children

    Sarah E. Romens;Jennifer McDonald;John Svaren;Seth D. Pollak

  • EGR2 Mutations in Inherited Neuropathies Dominant-Negatively Inhibit Myelin Gene Expression

    Rakesh Nagarajan;John Svaren;Nam Le;Toshiyuki Araki

  • MYRF Is a Membrane-Associated Transcription Factor That Autoproteolytically Cleaves to Directly Activate Myelin Genes

    Helena Bujalka;Matthias Koenning;Stacey Jackson;Victoria M. Perreau

  • The molecular machinery of myelin gene transcription in Schwann cells

    John Svaren;Dies Meijer

  • Transcription factors vs nucleosomes: regulation of the PH05 promoter in yeast

    John Svaren;Wolfram Hörz

  • EGR1 Target Genes in Prostate Carcinoma Cells Identified by Microarray Analysis

    John Svaren;Torsten Ehrig;Sarki A. Abdulkadir;Markus U. Ehrengruber

  • Impaired prostate tumorigenesis in Egr1-deficient mice.

    Sarki A. Abdulkadir;Zhican Qu;Emily Garabedian;Sheng Kwei Song

  • Activation of Luteinizing Hormone β Gene by Gonadotropin-releasing Hormone Requires the Synergy of Early Growth Response-1 and Steroidogenic Factor-1

    Christoph Dorn;Qinglin Ou;John Svaren;Peter A. Crawford

  • HDAC-mediated deacetylation of NF-κB is critical for Schwann cell myelination

    Ying Chen;Haibo Wang;Sung Ok Yoon;Xiaomei Xu

  • A nucleosome precludes binding of the transcription factor Pho4 in vivo to a critical target site in the PHO5 promoter.

    U. Venter;J. Svaren;J. Schmitz;A. Schmid

  • The structure and assembly of active chromatin

    John Svaren;Roger Chalkley

  • YAP and TAZ control peripheral myelination and the expression of laminin receptors in Schwann cells

    Yannick Poitelon;Camila Lopez-Anido;Kathleen Catignas;Caterina Berti

  • Functional Consequences of Mutations in the Early Growth Response 2 Gene (EGR2) Correlate with Severity of Human Myelinopathies

    Laura E. Warner;John Svaren;Jeffrey Milbrandt;James R. Lupski;James R. Lupski

  • The transactivation domain of Pho4 is required for nucleosome disruption at the PHO5 promoter.

    J Svaren;J Schmitz;W Hörz

  • Nab1, a Corepressor of NGFI-A (Egr-1), Contains an Active Transcriptional Repression Domain

    Alexander H. Swirnoff;Elizabeth D. Apel;John Svaren;Bradley R. Sevetson

  • Nab proteins are essential for peripheral nervous system myelination

    Nam Le;Rakesh Nagarajan;James Y T Wang;John Svaren

  • NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex.

    Rajini Srinivasan;Gennifer M. Mager;Rebecca M. Ward;Joshua Mayer

  • Charcot-Marie-Tooth disease

    Phu Duong;John Svaren

Frequent Co-Authors

Wolfram Hörz
Wolfram Hörz Ludwig-Maximilians-Universität München
Lawrence Wrabetz
Lawrence Wrabetz University at Buffalo, State University of New York
M. Suresh
M. Suresh University of Wisconsin–Madison
Michael E. Shy
Michael E. Shy University of Iowa
Mary M. Reilly
Mary M. Reilly University College London
Roger Chalkley
Roger Chalkley Vanderbilt University
Rhona Mirsky
Rhona Mirsky University College London
Rashmi Bansal
Rashmi Bansal University of Connecticut
Stephan Züchner
Stephan Züchner University of Miami
Frank Baas
Frank Baas Leiden University Medical Center

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