World's Best Scientists 2026 revealed!

D-Index & Metrics

Genetics

D-Index
112
Citations
44496
World Ranking
497
National Ranking
18

Medicine

D-Index
115
Citations
46307
World Ranking
4572
National Ranking
176

Overview

Frank Baas is affiliated with Leiden University Medical Center in the Netherlands, contributing extensively to research in medicine and biochemistry, genetics, and molecular biology. Their work spans several interconnected subfields, including neurology, genetics, molecular biology, immunology, and cellular and molecular neuroscience.

The scientist's recent publications reflect a focus on neurodegenerative diseases, genetic variants, and neuroinflammation. Selected papers include:

  • TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A, 2022, Nature
  • Association of Variants in the SPTLC1 Gene With Juvenile Amyotrophic Lateral Sclerosis, 2021, JAMA Neurology
  • A Large-Scale Full GBA1 Gene Screening in Parkinson's Disease in the Netherlands, 2020, Movement Disorders
  • Tackling Neuroinflammation After Traumatic Brain Injury: Complement Inhibition as a Therapy for Secondary Injury, 2022, Neurotherapeutics
  • An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients, 2021, iScience

Baas has worked frequently with a number of coauthors, including:

  • Hemali Phatnani
  • Kees Fluiter
  • Zachary Simmons
  • Ernest Fraenkel
  • Leslie M. Thompson

The scientist regularly publishes in venues such as Frontiers in Cellular Neuroscience, bioRxiv (Cold Spring Harbor Laboratory), Nature, Blood, and Trials. These platforms reflect a research focus that bridges basic biomedical sciences and clinical applications.

The main research topics covered in Baas's work include:

  • Amyotrophic Lateral Sclerosis Research
  • Neurogenetic and Muscular Disorders Research
  • Genomics and Rare Diseases
  • RNA Research and Splicing
  • Intracerebral and Subarachnoid Hemorrhage Research
  • Hemoglobinopathies and Related Disorders
  • Hereditary Neurological Disorders

Frank Baas's publication record, spanning medicine and molecular biology domains, shows a sustained engagement with neurological disorders and the genetic and molecular mechanisms underlying them. Their work contributes to advancing understanding of diseases such as ALS and Parkinson's through genetic screening, multi-omic analyses, and investigations into neuroinflammation.

Best Publications

  • Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines.

    M. Kool;M. De Haas;G. L. Scheffer;R. J. Scheper

  • Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

    Elizabeth T. Cirulli;Brittany N Lasseigne;Slave Petrovski;Peter C Sapp

  • The Human Transcriptome Map: Clustering of Highly Expressed Genes in Chromosomal Domains

    Huib Caron;Barbera van Schaik;Merlijn van der Mee;Frank Baas

  • The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump.

    G.J.R. Zaman;M.J. Flens;M.R. van Leusden;M. de Haas

  • Duplication in chromosome 17p11.2 in Charcot-Marie-Tooth neuropathy type 1a (CMT 1a). The HMSN Collaborative Research Group.

    P Raeymaekers;V Timmerman;E Nelis;P De Jonghe

  • MRP3, an organic anion transporter able to transport anti-cancer drugs

    M. Kool;M. van der Linden;M. de Haas;G. L. Scheffer

  • Identification of mutations in the gene encoding lamins A/C in autosomal dominant limb girdle muscular dystrophy with atrioventricular conduction disturbances (LGMD1B)

    Muchir A;Bonne G;van der Kooi Aj;van Meegen M

  • Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

    Aude Nicolas;Kevin P. Kenna;Alan E. Renton;Alan E. Renton;Nicola Ticozzi

  • Mutations in ABCC6 cause pseudoxanthoma elasticum.

    A.A. Bergen;A.S. Plomp;E.J. Schuurman;S. Terry

  • A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome.

    C. C. Paulusma;M. Kool;P. J. Bosma;G. L. Scheffer

  • Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein

    G J Zaman;J Lankelma;O van Tellingen;J Beijnen

  • The unfolded protein response is activated in Alzheimer's disease.

    J. J. M. Hoozemans;R. Veerhuis;E. S. Van Haastert;J. M. Rozemuller

  • Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA.

    R. Evers;M. Kool;L. Van Deemter;H. Janssen

  • Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs

    J Wijnholds;C A Mol;L van Deemter;M de Haas

  • Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism.

    José C Moreno;Hennie Bikker;Marlies J E Kempers;A S Paul van Trotsenburg

  • Abnormal heart rate and body temperature in mice lacking thyroid hormone receptor alpha 1.

    Lilian Wikström;Catarina Johansson;Carmen Saltó;Carrolee Barlow

  • Identical point mutations of PMP-22 in Trembler-J mouse and Charcot-Marie-Tooth disease type 1A.

    L J Valentijn;F Baas;R A Wolterman;J E Hoogendijk

  • Germline mutation of INI1/SMARCB1 in familial schwannomatosis.

    Theo J.M. Hulsebos;Astrid S. Plomp;Ruud A. Wolterman;Els C. Robanus-Maandag

  • N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom.

    Luba Kalaydjieva;Luba Kalaydjieva;David Gresham;Rebecca Gooding;Lisa Heather

  • Familial amyotrophic lateral sclerosis with frontotemporal dementia is linked to a locus on chromosome 9p13.2–21.3

    Caroline Vance;Ammar Al-Chalabi;Deborah Ruddy;Bradley N. Smith

Frequent Co-Authors

Peter G. Barth
Peter G. Barth Barth Syndrome Foundation
Marina A.J. Tijssen
Marina A.J. Tijssen University Medical Center Groningen
Wiep Scheper
Wiep Scheper Utrecht University
Paul P. Tak
Paul P. Tak GlaxoSmithKline (United Kingdom)
Dirk Troost
Dirk Troost University of Amsterdam
Piet Borst
Piet Borst Antoni van Leeuwenhoek Hospital
Arie van der Ende
Arie van der Ende University of Amsterdam
Eleonora Aronica
Eleonora Aronica University of Amsterdam
Marcel Kool
Marcel Kool German Cancer Research Center
Christopher Shaw
Christopher Shaw King's College London

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