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Biology and Biochemistry

D-Index
49
Citations
37009
World Ranking
17799
National Ranking
431

Overview

Wiep Scheper is a researcher affiliated with Utrecht University in the Netherlands, focusing on multiple areas within biomedical science. Their primary fields of study include Medicine, Neuroscience, and Biochemistry, Genetics and Molecular Biology. Scheper's work particularly emphasizes subfields such as Physiology, Neurology, Molecular Biology, Cellular and Molecular Neuroscience, and Cell Biology.

Their research topics span several important aspects of neurodegenerative diseases and brain function, with notable attention to Alzheimer's disease research and treatments, neuroinflammation and neurodegeneration mechanisms, and endoplasmic reticulum stress and disease. Other major areas include Parkinson's disease mechanisms and treatments, neuroscience and neuropharmacology research, cholinesterase and neurodegenerative diseases, and functional brain connectivity studies.

Recent publications illustrate the depth and focus of their scientific inquiry. These include:

  • In vivo tau pathology is associated with synaptic loss and altered synaptic function (2021, Alzheimer s Research & Therapy)
  • The UPR in Neurodegenerative Disease: Not Just an Inside Job (2020, Biomolecules)
  • Unfolded protein response activation in C9orf72 frontotemporal dementia is associated with dipeptide pathology and granulovacuolar degeneration in granule cells (2020, Brain Pathology)
  • Neuron-specific translational control shift ensures proteostatic resilience during ER stress (2022, The EMBO Journal)
  • Untangling the origin and function of granulovacuolar degeneration bodies in neurodegenerative proteinopathies (2020, Acta Neuropathologica Communications)

Scheper frequently publishes in venues such as Alzheimer's & Dementia, Alzheimer s Research & Therapy, Acta Neuropathologica Communications, Current Protocols, and bioRxiv (Cold Spring Harbor Laboratory).

Their collaborative work often includes partnerships with several recurring coauthors, including Jeroen J.M. Hoozemans, Vera I. Wiersma, Kevin Llewelyn Batenburg, Vivi M. Heine, and Marta Jorge-Oliva, indicating sustained research relationships in neurodegeneration and related fields.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • The Unfolded Protein Response Is Activated in Pretangle Neurons in Alzheimer’s Disease Hippocampus

    Jeroen J.M. Hoozemans;Elise S. van Haastert;Diana A.T. Nijholt;Annemieke J.M. Rozemuller

  • The unfolded protein response is activated in Alzheimer's disease.

    J. J. M. Hoozemans;R. Veerhuis;E. S. Van Haastert;J. M. Rozemuller

  • Activation of the unfolded protein response in Parkinson's disease

    J J M Hoozemans;E S van Haastert;P Eikelenboom;R A I de Vos

  • The unfolded protein response in neurodegenerative diseases: a neuropathological perspective.

    Wiep Scheper;Jeroen J. M. Hoozemans

  • The significance of neuroinflammation in understanding Alzheimer's disease

    P. Eikelenboom;P. Eikelenboom;R. Veerhuis;W. Scheper;A. J. M. Rozemuller

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Activation of the unfolded protein response is an early event in Alzheimer's and Parkinson's disease.

    Jeroen J M Hoozemans;Elise S van Haastert;Diana A T Nijholt;Annemieke J M Rozemuller

  • The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies

    Diana A. T. Nijholt;Elise S. van Haastert;Annemieke J. M. Rozemuller;Wiep Scheper

  • IRE1 Signaling Exacerbates Alzheimer's Disease Pathogenesis

    Claudia Duran-Aniotz;Victor Hugo Cornejo;Sandra Espinoza;Álvaro O Ardiles

  • PEGylated nanoparticles bind to and alter amyloid-beta peptide conformation: toward engineering of functional nanomedicines for Alzheimer's disease.

    Davide Brambilla;Romain Verpillot;Benjamin Le Droumaguet;Julien Nicolas

  • Branched KLVFF tetramers strongly potentiate inhibition of beta-amyloid aggregation.

    Sidhartha M. Chafekar;Hinke Malda;Maarten Merkx;E. W. Meijer

  • Endoplasmic reticulum stress activates autophagy but not the proteasome in neuronal cells: implications for Alzheimer's disease

    D A T Nijholt;T R de Graaf;E S van Haastert;A Osório Oliveira

  • Proteasome Activation by Small Molecules.

    Yves Leestemaker;Annemieke de Jong;Katharina F. Witting;Renske Penning

  • Versatile and efficient targeting using a single nanoparticulate platform: application to cancer and Alzheimer's disease.

    Benjamin Le Droumaguet;Julien Nicolas;Davide Brambilla;Simona Mura

  • Liposomes bi-functionalized with phosphatidic acid and an ApoE-derived peptide affect Aβ aggregation features and cross the blood–brain-barrier: Implications for therapy of Alzheimer disease

    Laura Bana;Stefania Minniti;Elisa Salvati;Silvia Sesana

  • Oligomer-specific Abeta toxicity in cell models is mediated by selective uptake.

    Sidhartha M. Chafekar;Frank Baas;Wiep Scheper

Frequent Co-Authors

Frank Baas
Frank Baas Leiden University Medical Center
Piet Eikelenboom
Piet Eikelenboom Vrije Universiteit Amsterdam
Sergio Lavandero
Sergio Lavandero University of Chile
Boris Zhivotovsky
Boris Zhivotovsky Karolinska Institute
Evelina Gatti
Evelina Gatti Aix-Marseille University
Philippe Pierre
Philippe Pierre Aix-Marseille University
Felix Randow
Felix Randow MRC Laboratory of Molecular Biology
Beth Levine
Beth Levine The University of Texas Southwestern Medical Center
Steven Finkbeiner
Steven Finkbeiner University of California, San Francisco
Stephen A. Spector
Stephen A. Spector University of California, San Diego

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