D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Medicine D-index 85 Citations 19,498 275 World Ranking 9761 National Ranking 5162
Biology and Biochemistry D-index 88 Citations 20,805 301 World Ranking 1761 National Ranking 999

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • DNA

His scientific interests lie mostly in Internal medicine, Endocrinology, Biochemistry, Apolipoprotein B and Molecular biology. His Internal medicine research focuses on Cholesterol, Adipose tissue, Lipoprotein, Fatty liver and Adipocyte. His research in Adipose tissue intersects with topics in Lipid droplet and Insulin resistance.

Adipogenesis, Very low-density lipoprotein, Lipoprotein lipase, Triglyceride and Insulin are the primary areas of interest in his Endocrinology study. Lawrence Chan works mostly in the field of Apolipoprotein B, limiting it down to concerns involving Genetic enhancement and, occasionally, Lesion. The study incorporates disciplines such as Complementary DNA, RNA and Chromosome 7 in addition to Molecular biology.

His most cited work include:

  • Protection against fatty liver but normal adipogenesis in mice lacking adipose differentiation-related protein. (254 citations)
  • Mechanism of action of the sex steroid hormones (first of three parts). (249 citations)
  • Structure and evolution of the lipase superfamily (243 citations)

What are the main themes of his work throughout his whole career to date?

His main research concerns Internal medicine, Endocrinology, Molecular biology, Biochemistry and Apolipoprotein B. His study ties his expertise on Genetic enhancement together with the subject of Internal medicine. Diabetes mellitus, Cholesterol, Lipoprotein, Insulin and Very low-density lipoprotein are among the areas of Endocrinology where the researcher is concentrating his efforts.

The Molecular biology study combines topics in areas such as Genetics, Nucleic acid sequence, Southern blot, Complementary DNA and Gene. His Apolipoprotein B research incorporates themes from RNA editing, Gene expression, Messenger RNA and Low-density lipoprotein. His work deals with themes such as Lesion and Receptor, which intersect with LDL receptor.

He most often published in these fields:

  • Internal medicine (52.50%)
  • Endocrinology (52.19%)
  • Molecular biology (23.75%)

What were the highlights of his more recent work (between 2009-2018)?

  • Internal medicine (52.50%)
  • Endocrinology (52.19%)
  • Insulin resistance (6.25%)

In recent papers he was focusing on the following fields of study:

His primary areas of study are Internal medicine, Endocrinology, Insulin resistance, Adipose tissue and Insulin. His study in Internal medicine is interdisciplinary in nature, drawing from both Diabetes mellitus and Diabetic neuropathy. Lawrence Chan has included themes like AMPK and Immunology in his Endocrinology study.

His Immunology study incorporates themes from Cancer research, Apolipoprotein E and Type 1 diabetes. His Insulin resistance study combines topics in areas such as Carbohydrate metabolism and Ghrelin. His Fatty liver research is multidisciplinary, incorporating elements of Phospholipase and Alanine transaminase.

Between 2009 and 2018, his most popular works were:

  • Patatin‐like phospholipase domain‐containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease (175 citations)
  • Patatin‐like phospholipase domain‐containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease (175 citations)
  • Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues (123 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • DNA

Lawrence Chan mainly focuses on Internal medicine, Endocrinology, Insulin resistance, Adipose tissue and Diabetes mellitus. His study in AMPK extends to Internal medicine with its themes. He undertakes multidisciplinary investigations into Endocrinology and Dorsal root ganglion in his work.

While the research belongs to areas of Insulin resistance, he spends his time largely on the problem of Ghrelin, intersecting his research to questions surrounding Genetically modified mouse, Brain-derived neurotrophic factor, Hyperinsulinemia, Glucose tolerance test and Thermogenin. The concepts of his Diabetes mellitus study are interwoven with issues in FGF21 and Fibroblast growth factor. His Glucose homeostasis research integrates issues from Receptor, Very low-density lipoprotein, Glucagon-Like Peptide-2 Receptor and Triglyceride.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Protection against Fatty Liver but Normal Adipogenesis in Mice Lacking Adipose Differentiation-Related Protein

Benny Hung-Junn Chang;Lan Li;Antoni Paul;Susumu Taniguchi.
Molecular and Cellular Biology (2006)

400 Citations

Mechanism of action of the sex steroid hormones (second of three parts).

Lawrence Chan;Bert W. O'Malley.
The New England Journal of Medicine (1976)

382 Citations

The absence of p53 accelerates atherosclerosis by increasing cell proliferation in vivo.

Natalia V. Guevara;Natalia V. Guevara;Han Seob Kim;Ekaterina I. Antonova;Lawrence Chan.
Nature Medicine (1999)

370 Citations

Structure and evolution of the lipase superfamily

W. A. Hide;L. Chan;Wen-Hsiung Li.
Journal of Lipid Research (1992)

361 Citations

Post-translational Modifications of the Four Conserved Lysine Residues within the Collagenous Domain of Adiponectin Are Required for the Formation of Its High Molecular Weight Oligomeric Complex

Yu Wang;Yu Wang;Karen S.L. Lam;Lawrence Chan;Kok Weng Chan.
Journal of Biological Chemistry (2006)

341 Citations

The db/db mouse, a model for diabetic dyslipidemia: Molecular characterization and effects of western diet feeding

Kunihisa Kobayashi;Trudy M. Forte;Susumu Taniguchi;Brian Y. Ishida.
Metabolism-clinical and Experimental (2000)

333 Citations

Apolipoprotein B, the major protein component of triglyceride-rich and low density lipoproteins.

L Chan.
Journal of Biological Chemistry (1992)

322 Citations

Insulin Regulation of Lipoprotein Lipase Activity in 3T3-L1 Adipocytes is Mediated at Posttranscriptional and Posttranslational Levels

C F Semenkovich;M Wims;L Noe;J Etienne.
Journal of Biological Chemistry (1989)

313 Citations

Lifetime correction of genetic deficiency in mice with a single injection of helper-dependent adenoviral vector

In-Hoo Kim;Alicja Józkowicz;Pedro A. Piedra;Kazuhiro Oka.
Proceedings of the National Academy of Sciences of the United States of America (2001)

310 Citations

The complete cDNA and amino acid sequence of human apolipoprotein B-100.

S. H. Chen;C. Y. Yang;P. F. Chen;D. Setzer.
Journal of Biological Chemistry (1986)

301 Citations

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