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Molecular Biology

D-Index
48
Citations
10275
World Ranking
2673
National Ranking
1302

Overview

Kristen W. Lynch is affiliated with the University of Pennsylvania in the United States. Their research primarily intersects the fields of biochemistry, genetics, and molecular biology, with a focus on molecular biology, immunology, cancer research, hematology, and infectious diseases.

Their work extensively explores topics related to RNA research and splicing, RNA modifications and cancer, RNA and protein synthesis mechanisms, cancer-related molecular mechanisms, interferon and immune responses, immune cell function and interaction, and acute myeloid leukemia research.

Recent publications by Kristen W. Lynch include the following papers:

  • Pharmacological activation of STING blocks SARS-CoV-2 infection, 2021, Science Immunology
  • Alternative splicing and cancer: insights, opportunities, and challenges from an expanding view of the transcriptome, 2020, Genes & Development
  • Viral-induced alternative splicing of host genes promotes influenza replication, 2020, eLife
  • The three as: Alternative splicing, alternative polyadenylation and their impact on apoptosis in immune function, 2021, Immunological Reviews
  • Alternative splicing redefines landscape of commonly mutated genes in acute myeloid leukemia, 2021, Proceedings of the National Academy of Sciences

Kristen W. Lynch frequently collaborates with other researchers, including:

  • Max Ferretti
  • Yoseph Barash
  • Mathieu Quesnel-Vallières
  • Sara Cherry
  • Andrei Thomas-Tikhonenko

Their publications are commonly found in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Cell Reports, Nucleic Acids Research, and The Journal of Immunology.

Best Publications

  • A compendium of RNA-binding motifs for decoding gene regulation

    Debashish Ray;Hilal Kazan;Kate B. Cook;Matthew T. Weirauch;Matthew T. Weirauch

  • Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy

    Elena Sotillo;David M. Barrett;Kathryn L. Black;Asen Bagashev

  • A new view of transcriptome complexity and regulation through the lens of local splicing variations

    Jorge Vaquero-Garcia;Alejandro Barrera;Matthew R Gazzara;Juan González-Vallinas

  • An optogenetic gene expression system with rapid activation and deactivation kinetics

    Laura B Motta-Mena;Anna Reade;Michael J Mallory;Spencer Glantz

  • Assembly of specific SR protein complexes on distinct regulatory elements of the Drosophila doublesex splicing enhancer.

    K W Lynch;T Maniatis

  • Consequences of regulated pre-mRNA splicing in the immune system.

    Kristen W. Lynch

  • Global analysis of alternative splicing during T-cell activation

    Joanna Y. Ip;Alan Tong;Qun Pan;Justin D. Topp

  • Regulation of Alternative Splicing: More than Just the ABCs

    Amy E. House;Kristen W. Lynch

  • Synergistic interactions between two distinct elements of a regulated splicing enhancer.

    Kristen W. Lynch;Tom Maniatis

  • Control of alternative splicing in immune responses: many regulators, many predictions, much still to learn.

    Nicole M. Martinez;Kristen W. Lynch

  • Common themes in the function of transcription and splicing enhancers.

    Klemens J Hertel;Kristen W Lynch;Tom Maniatis

  • A Model System for Activation-Induced Alternative Splicing of CD45 Pre-mRNA in T Cells Implicates Protein Kinase C and Ras

    Kristen W. Lynch;Arthur Weiss

  • HnRNP L represses exon splicing via a regulated exonic splicing silencer

    Caryn R Rothrock;Amy E House;Kristen W Lynch

  • A CD45 polymorphism associated with multiple sclerosis disrupts an exonic splicing silencer.

    Kristen W. Lynch;Arthur Weiss

  • Phosphorylation-Dependent Regulation of PSF by GSK3 Controls CD45 Alternative Splicing

    Florian Heyd;Kristen W. Lynch

  • Pharmacological activation of STING blocks SARS-CoV-2 infection.

    Minghua Li;Max Ferretti;Baoling Ying;Hélène Descamps

  • An exonic splicing silencer represses spliceosome assembly after ATP-dependent exon recognition

    Amy E House;Kristen W Lynch

  • Stem-Loop Recognition by DDX17 Facilitates miRNA Processing and Antiviral Defense

    Ryan H. Moy;Brian S. Cole;Ari Yasunaga;Beth Gold

  • A cell-based screen for splicing regulators identifies hnRNP LL as a distinct signal-induced repressor of CD45 variable exon 4.

    Justin D. Topp;Jason Jackson;Alexis A. Melton;Kristen W. Lynch

  • Regulation of Alternative Splicing: More than Just

    Amy E. House;Kristen W. Lynch

Frequent Co-Authors

Sara Cherry
Sara Cherry University of Pennsylvania
Adolfo García-Sastre
Adolfo García-Sastre Icahn School of Medicine at Mount Sinai
Xiang-Dong Fu
Xiang-Dong Fu Westlake University
Tom Maniatis
Tom Maniatis Columbia University
Martin Carroll
Martin Carroll University of Pennsylvania
Benjamin A. Garcia
Benjamin A. Garcia Washington University in St. Louis
Benjamin J. Blencowe
Benjamin J. Blencowe University of Toronto
John B. Hogenesch
John B. Hogenesch Cincinnati Children's Hospital Medical Center
Arthur Weiss
Arthur Weiss University of California, San Francisco
Matthew T. Weirauch
Matthew T. Weirauch Cincinnati Children's Hospital Medical Center

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