His scientific interests lie mostly in RNA splicing, Alternative splicing, Genetics, Exon and Intron. The various areas that he examines in his RNA splicing study include Molecular biology, Gene expression, Computational biology and RNA-binding protein. His research integrates issues of Mutation and Human genome in his study of Alternative splicing.
He is involved in the study of Genetics that focuses on Exonic splicing enhancer in particular. In his research, Endocrinology, Protein kinase C and Hyperphosphorylation is intimately related to Myotonic dystrophy, which falls under the overarching field of RNA. His MBNL1 study incorporates themes from Myotonic Disorder and Skeletal muscle.
RNA splicing, Alternative splicing, Genetics, Cell biology and Exon are his primary areas of study. His RNA splicing study integrates concerns from other disciplines, such as Molecular biology, RNA-binding protein and Intron. The Alternative splicing study combines topics in areas such as Gene expression and Myotonic dystrophy.
In Myotonic dystrophy, Thomas A. Cooper works on issues like RNA, which are connected to DNA. His work carried out in the field of Genetics brings together such families of science as Computational biology and Pathogenesis. His work on C2C12 as part of general Cell biology study is frequently linked to Heart development, bridging the gap between disciplines.
Thomas A. Cooper mostly deals with Cell biology, RNA splicing, Alternative splicing, Skeletal muscle and Myotonic dystrophy. His Cell biology research is multidisciplinary, incorporating elements of CELF1 Protein, Photoreceptor degeneration, Gene expression and Trinucleotide repeat expansion. His RNA splicing research is within the category of Genetics.
His Alternative splicing study contributes to a more complete understanding of Gene. His biological study spans a wide range of topics, including Autophagy and Proteostasis. The study incorporates disciplines such as Endocrinology, Wasting, Cardiac conduction and Exon in addition to Myotonic dystrophy.
The scientist’s investigation covers issues in RNA splicing, Genetics, Skeletal muscle, Cell biology and Gene expression. Many of his studies on RNA splicing involve topics that are commonly interrelated, such as Regulatory sequence. His research integrates issues of Autophagy, Protein degradation, Transcriptome, Alternative splicing and Proteostasis in his study of Skeletal muscle.
His Alternative splicing research incorporates themes from Muscle relaxation and NFAT. Thomas A. Cooper has included themes like RNA, CELF1 Protein, DNA and Trinucleotide repeat expansion in his Cell biology study. His studies deal with areas such as Alu element, Duchenne muscular dystrophy, Myotonic dystrophy and Genome as well as Exon.
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Pre-mRNA splicing and human disease
Nuno André Faustino;Thomas A. Cooper.
Genes & Development (2003)
RNA and Disease
Thomas A. Cooper;Lili Wan;Gideon Dreyfuss.
Splicing in disease: disruption of the splicing code and the decoding machinery
Guey-Shin Wang;Thomas A. Cooper.
Nature Reviews Genetics (2007)
Disruption of Splicing Regulated by a CUG-Binding Protein in Myotonic Dystrophy
Anne V. Philips;Lubov T. Timchenko;Thomas A. Cooper.
Aberrant regulation of insulin receptor alternative splicing is associated with insulin resistance in myotonic dystrophy
Rajesh S. Savkur;Anne V. Philips;Thomas A. Cooper.
Nature Genetics (2001)
Loss of the muscle-specific chloride channel in type 1 myotonic dystrophy due to misregulated alternative splicing.
Nicolas Charlet-B.;Rajesh S. Savkur;Gopal Singh;Anne V. Philips.
Molecular Cell (2002)
Functional consequences of developmentally regulated alternative splicing
Auinash Kalsotra;Thomas A. Cooper.
Nature Reviews Genetics (2011)
The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo
Kristen L. Meerbrey;Guang Hu;Jessica D. Kessler;Kevin Roarty.
Proceedings of the National Academy of Sciences of the United States of America (2011)
RNA-mediated neuromuscular disorders.
Laura P W Ranum;Thomas A Cooper.
Annual Review of Neuroscience (2006)
A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart
Auinash Kalsotra;Xinshu Xiao;Amanda J. Ward;John C. Castle.
Proceedings of the National Academy of Sciences of the United States of America (2008)
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