D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Genetics D-index 68 Citations 21,838 123 World Ranking 1670 National Ranking 771

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Gene expression

His scientific interests lie mostly in RNA splicing, Alternative splicing, Genetics, Exon and Intron. The various areas that he examines in his RNA splicing study include Molecular biology, Gene expression, Computational biology and RNA-binding protein. His research integrates issues of Mutation and Human genome in his study of Alternative splicing.

He is involved in the study of Genetics that focuses on Exonic splicing enhancer in particular. In his research, Endocrinology, Protein kinase C and Hyperphosphorylation is intimately related to Myotonic dystrophy, which falls under the overarching field of RNA. His MBNL1 study incorporates themes from Myotonic Disorder and Skeletal muscle.

His most cited work include:

  • Pre-mRNA splicing and human disease (1060 citations)
  • RNA and Disease (888 citations)
  • Splicing in disease: disruption of the splicing code and the decoding machinery (792 citations)

What are the main themes of his work throughout his whole career to date?

RNA splicing, Alternative splicing, Genetics, Cell biology and Exon are his primary areas of study. His RNA splicing study integrates concerns from other disciplines, such as Molecular biology, RNA-binding protein and Intron. The Alternative splicing study combines topics in areas such as Gene expression and Myotonic dystrophy.

In Myotonic dystrophy, Thomas A. Cooper works on issues like RNA, which are connected to DNA. His work carried out in the field of Genetics brings together such families of science as Computational biology and Pathogenesis. His work on C2C12 as part of general Cell biology study is frequently linked to Heart development, bridging the gap between disciplines.

He most often published in these fields:

  • RNA splicing (66.92%)
  • Alternative splicing (60.90%)
  • Genetics (46.62%)

What were the highlights of his more recent work (between 2016-2021)?

  • Cell biology (36.09%)
  • RNA splicing (66.92%)
  • Alternative splicing (60.90%)

In recent papers he was focusing on the following fields of study:

Thomas A. Cooper mostly deals with Cell biology, RNA splicing, Alternative splicing, Skeletal muscle and Myotonic dystrophy. His Cell biology research is multidisciplinary, incorporating elements of CELF1 Protein, Photoreceptor degeneration, Gene expression and Trinucleotide repeat expansion. His RNA splicing research is within the category of Genetics.

His Alternative splicing study contributes to a more complete understanding of Gene. His biological study spans a wide range of topics, including Autophagy and Proteostasis. The study incorporates disciplines such as Endocrinology, Wasting, Cardiac conduction and Exon in addition to Myotonic dystrophy.

Between 2016 and 2021, his most popular works were:

  • The roles of RNA processing in translating genotype to phenotype (92 citations)
  • Transcriptome alterations in myotonic dystrophy skeletal muscle and heart. (35 citations)
  • Unexpected consequences: exon skipping caused by CRISPR-generated mutations. (35 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Gene expression

The scientist’s investigation covers issues in RNA splicing, Genetics, Skeletal muscle, Cell biology and Gene expression. Many of his studies on RNA splicing involve topics that are commonly interrelated, such as Regulatory sequence. His research integrates issues of Autophagy, Protein degradation, Transcriptome, Alternative splicing and Proteostasis in his study of Skeletal muscle.

His Alternative splicing research incorporates themes from Muscle relaxation and NFAT. Thomas A. Cooper has included themes like RNA, CELF1 Protein, DNA and Trinucleotide repeat expansion in his Cell biology study. His studies deal with areas such as Alu element, Duchenne muscular dystrophy, Myotonic dystrophy and Genome as well as Exon.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Pre-mRNA splicing and human disease

Nuno André Faustino;Thomas A. Cooper.
Genes & Development (2003)

1568 Citations

RNA and Disease

Thomas A. Cooper;Lili Wan;Gideon Dreyfuss.
Cell (2009)

1238 Citations

Splicing in disease: disruption of the splicing code and the decoding machinery

Guey-Shin Wang;Thomas A. Cooper.
Nature Reviews Genetics (2007)

1146 Citations

Disruption of Splicing Regulated by a CUG-Binding Protein in Myotonic Dystrophy

Anne V. Philips;Lubov T. Timchenko;Thomas A. Cooper.
Science (1998)

921 Citations

Aberrant regulation of insulin receptor alternative splicing is associated with insulin resistance in myotonic dystrophy

Rajesh S. Savkur;Anne V. Philips;Thomas A. Cooper.
Nature Genetics (2001)

901 Citations

Loss of the muscle-specific chloride channel in type 1 myotonic dystrophy due to misregulated alternative splicing.

Nicolas Charlet-B.;Rajesh S. Savkur;Gopal Singh;Anne V. Philips.
Molecular Cell (2002)

650 Citations

Functional consequences of developmentally regulated alternative splicing

Auinash Kalsotra;Thomas A. Cooper.
Nature Reviews Genetics (2011)

634 Citations

The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo

Kristen L. Meerbrey;Guang Hu;Jessica D. Kessler;Kevin Roarty.
Proceedings of the National Academy of Sciences of the United States of America (2011)

596 Citations

RNA-mediated neuromuscular disorders.

Laura P W Ranum;Thomas A Cooper.
Annual Review of Neuroscience (2006)

553 Citations

A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart

Auinash Kalsotra;Xinshu Xiao;Amanda J. Ward;John C. Castle.
Proceedings of the National Academy of Sciences of the United States of America (2008)

501 Citations

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