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Genetics

D-Index
74
Citations
25391
World Ranking
1948
National Ranking
893

Overview

Thomas A. Cooper is affiliated with Baylor College of Medicine in the United States. Their research primarily focuses on the interface of biochemistry, genetics, and molecular biology, with additional work in medicine and neuroscience. The scientist's subfields include molecular biology, cellular and molecular neuroscience, cardiology and cardiovascular medicine, neurology, and genetics, reflecting a multidisciplinary approach to their investigations.

The scientist's work spans several major topics, such as genetic neurodegenerative diseases, RNA research and splicing, mitochondrial function and pathology, muscle physiology and disorders, cardiomyopathy and myosin studies, Parkinson's disease mechanisms and treatments, and neurogenetic and muscular disorders research.

Notable recent publications include:

  • "Aberrant Expression of a Non-muscle RBFOX2 Isoform Triggers Cardiac Conduction Defects in Myotonic Dystrophy" (2020) published in Developmental Cell
  • "Clinical and Molecular Insights into Gastrointestinal Dysfunction in Myotonic Dystrophy Types 1 & 2" (2022) published in International Journal of Molecular Sciences
  • "Alternative splicing mediates the compensatory upregulation of MBNL2 upon MBNL1 loss-of-function" (2023) published in Nucleic Acids Research
  • "Increased nuclear but not cytoplasmic activities of CELF1 protein leads to muscle wasting" (2020) published in Human Molecular Genetics
  • "Reversible cardiac disease features in an inducible CUG repeat RNA-expressing mouse model of myotonic dystrophy" (2021) published in JCI Insight

Frequent publication venues for their work include:

  • International Journal of Molecular Sciences
  • Human Molecular Genetics
  • Journal of Clinical Investigation
  • Developmental Cell
  • Nucleic Acids Research

Thomas A. Cooper has collaborated frequently with several researchers, including:

  • Larissa Nitschke
  • Rong-Chi Hu
  • Zheng Xia
  • Andrew N. Miller
  • Lathan Lucas

Best Publications

  • Pre-mRNA splicing and human disease

    Nuno André Faustino;Thomas A. Cooper

  • RNA and Disease

    Thomas A. Cooper;Lili Wan;Gideon Dreyfuss

  • Splicing in disease: disruption of the splicing code and the decoding machinery

    Guey-Shin Wang;Thomas A. Cooper

  • Aberrant regulation of insulin receptor alternative splicing is associated with insulin resistance in myotonic dystrophy

    Rajesh S. Savkur;Anne V. Philips;Thomas A. Cooper

  • Disruption of Splicing Regulated by a CUG-Binding Protein in Myotonic Dystrophy

    Anne V. Philips;Lubov T. Timchenko;Thomas A. Cooper

  • The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo

    Kristen L. Meerbrey;Guang Hu;Jessica D. Kessler;Kevin Roarty

  • Functional consequences of developmentally regulated alternative splicing

    Auinash Kalsotra;Thomas A. Cooper

  • Loss of the muscle-specific chloride channel in type 1 myotonic dystrophy due to misregulated alternative splicing.

    Nicolas Charlet-B.;Rajesh S. Savkur;Gopal Singh;Anne V. Philips

  • RNA-mediated neuromuscular disorders.

    Laura P W Ranum;Thomas A Cooper

  • A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart

    Auinash Kalsotra;Xinshu Xiao;Amanda J. Ward;John C. Castle

  • Muscleblind proteins regulate alternative splicing

    Thai H Ho;Nicolas Charlet-B;Michael G Poulos;Gopal Singh

  • The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing.

    Andrea N. Ladd;Nicolas Charlet-B.;Thomas A. Cooper

  • Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3'-UTR landscape across seven tumour types.

    Zheng Xia;Lawrence A. Donehower;Thomas A. Cooper;Joel R. Neilson

  • The pathobiology of splicing

    Amanda J Ward;Thomas A Cooper

  • Pre-mRNA splicing in disease and therapeutics

    Ravi K. Singh;Thomas A. Cooper

  • Increased steady-state levels of CUGBP1 in myotonic dystrophy 1 are due to PKC-mediated hyperphosphorylation.

    N. Muge Kuyumcu-Martinez;Guey-Shin Wang;Thomas A. Cooper

  • The spliceosome is a therapeutic vulnerability in MYC-driven cancer

    Tiffany Y.T. Hsu;Lukas M. Simon;Nicholas J. Neill;Richard Marcotte

  • A single cardiac troponin T gene generates embryonic and adult isoforms via developmentally regulated alternate splicing.

    T A Cooper;C P Ordahl

  • Expression of 24,426 human alternative splicing events and predicted cis regulation in 48 tissues and cell lines.

    John C Castle;Chaolin Zhang;Jyoti K Shah;Amit V Kulkarni

  • Pathogenic mechanisms of myotonic dystrophy.

    Johanna E. Lee;Thomas A. Cooper

Frequent Co-Authors

Xander H.T. Wehrens
Xander H.T. Wehrens Baylor College of Medicine
Eric T. Wang
Eric T. Wang University of Florida
Luc Buée
Luc Buée University of Lille
Maurice S. Swanson
Maurice S. Swanson University of Florida
Thomas F. Westbrook
Thomas F. Westbrook Baylor College of Medicine
Benjamin G. Neel
Benjamin G. Neel New York University Langone Medical Center
Peter J. Mohler
Peter J. Mohler The Ohio State University
Chad A. Shaw
Chad A. Shaw Baylor College of Medicine
Hugo J. Bellen
Hugo J. Bellen Baylor College of Medicine

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