World's Best Scientists 2026 revealed!
Christopher W.J. Smith

Christopher W.J. Smith

D-Index & Metrics

Biology and Biochemistry

D-Index
49
Citations
13020
World Ranking
17873
National Ranking
1411

Overview

Christopher W.J. Smith is affiliated with the University of Cambridge in the United Kingdom and has contributed extensively to the fields of Biochemistry, Genetics, and Molecular Biology. Their research primarily focuses on Molecular Biology with significant work also in Immunology, Cancer Research, Plant Science, and Immunology and Allergy.

Smith's main research topics include:

  • RNA Research and Splicing
  • RNA modifications and cancer
  • RNA and protein synthesis mechanisms
  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Signaling Pathways in Disease
  • Plant Disease Resistance and Genetics

Recent publications by Smith span high-impact journals and address diverse aspects of RNA biology and immunology. Notable papers include:

  • Alternative splicing as a source of phenotypic diversity, 2022, Nature Reviews Genetics
  • Polypyrimidine tract-binding proteins are essential for B cell development, 2020, eLife
  • Myocardin regulates exon usage in smooth muscle cells through induction of splicing regulatory factors, 2022, Cellular and Molecular Life Sciences
  • Cell-type specific regulator RBPMS switches alternative splicing via higher-order oligomerization and heterotypic interactions with other splicing regulators, 2023, Nucleic Acids Research
  • Essential requirement for polypyrimidine tract binding proteins 1 and 3 in the maturation and maintenance of mature B cells in mice, 2021, European Journal of Immunology

Their research has appeared frequently in venues such as bioRxiv (Cold Spring Harbor Laboratory) with four publications, alongside multiple articles in Nucleic Acids Research, European Journal of Immunology, Nature Structural & Molecular Biology, and Nature Reviews Genetics.

Frequent collaborators in Smith's work include:

  • Clare Gooding
  • Elisa Monzón-Casanova
  • Martin Turner
  • Yi Yang
  • Erick E Nakagaki-Silva

Smith's body of work addresses intricate aspects of RNA splicing, protein synthesis, and immune cell biology, with a particular emphasis on the molecular mechanisms underpinning phenotypic diversity, immune cell development, and regulatory pathways in disease processes.

Best Publications

  • Understanding alternative splicing: towards a cellular code.

    Arianne J. Matlin;Francis Clark;Christopher W. J. Smith

  • Alternative pre-mRNA splicing: the logic of combinatorial control.

    Christopher W.J Smith;Juan Valcárcel

  • Autoregulation of Polypyrimidine Tract Binding Protein by Alternative Splicing Leading to Nonsense-Mediated Decay

    Matthew C Wollerton;Clare Gooding;Eric J Wagner;Mariano A Garcia-Blanco

  • Alternative splicing resulting in nonsense-mediated mRNA decay: what is the meaning of nonsense?

    Nicholas J. McGlincy;Christopher W.J. Smith

  • Crossregulation and Functional Redundancy between the Splicing Regulator PTB and Its Paralogs nPTB and ROD1

    Rachel Spellman;Miriam Llorian;Christopher W.J. Smith

  • The FlyBase database of the Drosophila genome projects andcommunity literature

    William Gelbart;Leyla Bayraktaroglu;Brian Bettencourt;Kathy Campbell

  • Scanning from an independently specified branch point defines the 3' splice site of mammalian introns

    Christopher W. J. Smith;Elena B. Porro;James G. Patton;Bernardo Nadal-Ginard

  • Intron retention as a component of regulated gene expression programs

    Aishwarya G. Jacob;Christopher W. J. Smith

  • Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB

    Miriam Llorian;Schraga Schwartz;Tyson A Clark;Dror Hollander

  • Co-transcriptional commitment to alternative splice site selection

    G. C. Roberts;C. Gooding;Ho Yi Mak;N. J. Proudfoot

  • Genome-Wide Association between Branch Point Properties and Alternative Splicing

    André Corvelo;Martina Hallegger;Christopher W. J. Smith;Eduardo Eyras

  • Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells

    H. Dolatshad;A. Pellagatti;M. Fernandez-Mercado;B. H. Yip

  • Alternative splicing: combinatorial output from the genome

    Gavin C Roberts;Christopher W.J Smith

  • Polypyrimidine tract binding protein functions as a repressor to regulate alternative splicing of alpha-actinin mutally exclusive exons.

    Justine Southby;Clare Gooding;Christopher W. J. Smith

  • Novel modes of splicing repression by PTB.

    Rachel Spellman;Christopher W.J. Smith

  • Role of an inhibitory pyrimidine element and polypyrimidine tract binding protein in repression of a regulated alpha-tropomyosin exon.

    Clare Gooding;Gavin C. Roberts;Christopher W.J. Smith

  • Differential alternative splicing activity of isoforms of polypyrimidine tract binding protein (PTB)

    Matthew C. Wollerton;Clare Gooding;Fiona Robinson;Emma C. Brown

  • RNAi is antagonized by A→I hyper-editing

    A D J Scadden;Christopher W J Smith

  • Alternative splicing: global insights

    Martina Hallegger;Miriam Llorian;Christopher W. J. Smith

  • Nuclear matrix protein Matrin3 regulates alternative splicing and forms overlapping regulatory networks with PTB

    Miguel B. Coelho;Jan Attig;Nicolás Bellora;Julian König

Frequent Co-Authors

Jernej Ule
Jernej Ule The Francis Crick Institute
Nicholas M. Luscombe
Nicholas M. Luscombe The Francis Crick Institute
Mario Cazzola
Mario Cazzola University of Pavia
Andrea Pellagatti
Andrea Pellagatti University of Oxford
Martin R. Turner
Martin R. Turner University of Oxford
Seishi Ogawa
Seishi Ogawa Kyoto University
Stephen Curry
Stephen Curry Imperial College London
Elli Papaemmanuil
Elli Papaemmanuil Memorial Sloan Kettering Cancer Center
Eduardo Eyras
Eduardo Eyras Pompeu Fabra University
Ashok R. Venkitaraman
Ashok R. Venkitaraman Agency for Science, Technology and Research

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring Biology and Biochemistry can open doors to a wide range of career pathways. With the rise of online learning, students now have more accessible options than ever. For those interested in combining science with business, online healthcare MBA programs offer a flexible route to management roles within the healthcare sector.

Many students also choose to transition into the allied health field. Becoming a certified professional coder is a popular and stable option. It’s important to understand the differences between the main certifications; our guide on cpc certification outlines the key differences, including costs and salary prospects.

Medical coding offers competitive salaries, especially for those who earn credentials. Learn more about compensation in our article on certified medical coder salary. Additionally, the medical coding job outlook remains strong, making it an appealing option for science graduates looking for stability and opportunity.

Best Scientists Citing Christopher W.J. Smith

Trending Scientists