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Molecular Biology

D-Index
71
Citations
23278
World Ranking
1355
National Ranking
686

Research.com Recognitions

  • 2015 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Douglas L. Black is affiliated with the University of California, Los Angeles in the United States. Their research primarily spans Biochemistry, Genetics, and Molecular Biology, with a focus on Molecular Biology, Cancer Research, Genetics, Physiology, and Biochemistry as subfields.

The scientist's work engages deeply with topics related to RNA Research and Splicing, RNA modifications and cancer, RNA and protein synthesis mechanisms, cancer-related molecular mechanisms research, genomics and chromatin dynamics, advanced biosensing and bioanalysis techniques, and microRNA in disease regulation.

Douglas L. Black has frequently published in several venues, including bioRxiv (Cold Spring Harbor Laboratory), Nature, Proceedings of the National Academy of Sciences, Genes & Development, and Genome Research. These outlets reflect the scope and focus of their scientific investigations.

Recent selected papers authored include:

  • A protein assembly mediates Xist localization and gene silencing, 2020, Nature
  • Pathway-guided analysis identifies Myc-dependent alternative pre-mRNA splicing in aggressive prostate cancers, 2020, Proceedings of the National Academy of Sciences
  • Tracking pre-mRNA maturation across subcellular compartments identifies developmental gene regulation through intron retention and nuclear anchoring, 2021, Genome Research
  • XIST directly regulates X-linked and autosomal genes in naive human pluripotent cells, 2024, Cell
  • CLSTN3β enforces adipocyte multilocularity to facilitate lipid utilization, 2022, Nature

The scientist has collaborated extensively with several colleagues, including Chia-Ho Lin, Wen Xiao, Andrey Damianov, Kyu-Hyeon Yeom, and Kathrin Plath, reflecting an active engagement in collaborative research projects.

Douglas L. Black was recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 2015.

Best Publications

  • Mechanisms of Alternative Pre-Messenger RNA Splicing

    Douglas L. Black

  • Protein diversity from alternative splicing: a challenge for bioinformatics and post-genome biology.

    Douglas L Black

  • U2 as well as U1 small nuclear ribonucleoproteins are involved in premessenger RNA splicing

    Douglas L. Black;Benoit Chabot;Joan A. Steitz

  • A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons

    Paul L. Boutz;Peter Stoilov;Qin Li;Chia-Ho Lin

  • Structure of PTB bound to RNA: specific binding and implications for splicing regulation.

    Florian C. Oberstrass;Sigrid D. Auweter;Michèle Erat;Yann Hargous

  • Genome-wide Analysis of PTB-RNA Interactions Reveals a Strategy Used by the General Splicing Repressor to Modulate Exon Inclusion or Skipping

    Yuanchao Xue;Yu Zhou;Yu Zhou;Tongbin Wu;Tuo Zhu

  • m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover

    Shengdong Ke;Shengdong Ke;Amy Pandya-Jones;Yuhki Saito;Yuhki Saito;John J. Fak;John J. Fak

  • Neuronal regulation of alternative pre-mRNA splicing.

    Qin Li;Ji-Ann Lee;Douglas L. Black

  • Transcript Dynamics of Proinflammatory Genes Revealed by Sequence Analysis of Subcellular RNA Fractions

    Dev M. Bhatt;Amy Pandya-Jones;Ann Jay Tong;Iros Barozzi

  • Alternative RNA splicing in the nervous system.

    Paula J. Grabowski;Douglas L. Black

  • A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer.

    H Min;C W Turck;J M Nikolic;D L Black

  • Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein.

    Vadim Markovtsov;Julia M. Nikolic;Joseph A. Goldman;Christoph W. Turck

  • MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle development.

    Paul L. Boutz;Geetanjali Chawla;Peter Stoilov;Douglas L. Black

  • Rbfox proteins regulate alternative mRNA splicing through evolutionarily conserved RNA bridges

    Michael T Lovci;Dana Ghanem;Henry Marr;Justin Arnold

  • Co-transcriptional splicing of constitutive and alternative exons.

    Amy Pandya-Jones;Douglas L. Black

  • The splicing regulator Rbfox1 (A2BP1) controls neuronal excitation in the mammalian brain

    Lauren T Gehman;Peter Stoilov;Jamie Maguire;Andrey Damianov

  • HNRNP H IS A COMPONENT OF A SPLICING ENHANCER COMPLEX THAT ACTIVATES A C-SRC ALTERNATIVE EXON IN NEURONAL CELLS

    Min-Yuan Chou;Nanette Rooke;Christoph W. Turck;Douglas L. Black;Douglas L. Black

  • The 3' splice site of pre-messenger RNA is recognized by a small nuclear ribonucleoprotein.

    Benoit Chabot;Douglas L. Black;David M. LeMaster;Joan A. Steitz

  • A CaMK IV responsive RNA element mediates depolarization-induced alternative splicing of ion channels

    Jiuyong Xie;Douglas L. Black;Douglas L. Black

  • Functions of the Abundant U-snRNPs

    Joan A. Steitz;Douglas L. Black;Volker Gerke;Katherine A. Parker

Frequent Co-Authors

Yi Xing
Yi Xing Children's Hospital of Philadelphia
Ajay A. Vashisht
Ajay A. Vashisht University of California, Los Angeles
James A. Wohlschlegel
James A. Wohlschlegel University of California, Los Angeles
Xiang-Dong Fu
Xiang-Dong Fu Westlake University
Manuel Ares
Manuel Ares University of California, Santa Cruz
Kathrin Plath
Kathrin Plath University of California, Los Angeles
Kelsey C. Martin
Kelsey C. Martin University of California, Los Angeles
Mitchell Guttman
Mitchell Guttman California Institute of Technology
Heinrich Leonhardt
Heinrich Leonhardt Ludwig-Maximilians-Universität München

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