World's Best Scientists 2026 revealed!

D-Index & Metrics

Genetics

D-Index
62
Citations
61338
World Ranking
2925
National Ranking
1279

Research.com Recognitions

  • 2015 - Fellow of Alfred P. Sloan Foundation

Overview

Mitchell Guttman is affiliated with the California Institute of Technology in the United States. Their research output spans primarily the field of Biochemistry, Genetics, and Molecular Biology, with a focus on Molecular Biology as their most prominent subfield.

The scientist's work covers a range of topics, notably:

  • RNA Research and Splicing
  • Genomics and Chromatin Dynamics
  • RNA modifications and cancer
  • RNA and protein synthesis mechanisms
  • Cancer-related molecular mechanisms research
  • Single-cell and spatial transcriptomics
  • RNA regulation and disease

They have published extensively, including notable papers such as:

  • "Long non-coding RNAs: definitions, functions, challenges and recommendations" (2023) in Nature Reviews Molecular Cell Biology
  • "SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses" (2020) in Cell
  • "Integrated spatial genomics reveals global architecture of single nuclei" (2021) in Nature
  • "RNA promotes the formation of spatial compartments in the nucleus" (2021) in Cell
  • "Nuclear compartmentalization as a mechanism of quantitative control of gene expression" (2021) in Nature Reviews Molecular Cell Biology

The frequent publication venues for their work include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell
  • Nature
  • Molecular Cell
  • Nature Reviews Molecular Cell Biology

Mitchell Guttman collaborates regularly with several co-authors, including:

  • Mario R. Blanco
  • Sofia A. Quinodoz
  • Prashant Bhat
  • Joanna W. Jachowicz
  • Noah Ollikainen

In recognition of their contributions, they were named a Fellow of the Alfred P. Sloan Foundation in 2015.

Best Publications

  • Integrative genomics viewer

    James T Robinson;Helga Thorvaldsdóttir;Wendy Winckler;Mitchell Guttman

  • Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

    Mitchell Guttman;Ido Amit;Manuel Garber;Courtney French

  • Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

    Ahmad M. Khalil;Mitchell Guttman;Maite Huarte;Manuel Garber

  • Modular regulatory principles of large non-coding RNAs

    Mitchell Guttman;John L. Rinn;John L. Rinn

  • A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response

    Maite Huarte;Mitchell Guttman;Mitchell Guttman;David Feldser;Manuel Garber

  • lincRNAs act in the circuitry controlling pluripotency and differentiation

    Mitchell Guttman;Julie Donaghey;Bryce W. Carey;Manuel Garber

  • m 6 A RNA methylation promotes XIST -mediated transcriptional repression

    Deepak P. Patil;Chun-Kan Chen;Brian F. Pickering;Amy Chow

  • Ab initio reconstruction of cell type–specific transcriptomes in mouse reveals the conserved multi-exonic structure of lincRNAs

    Mitchell Guttman;Manuel Garber;Joshua Z Levin;Julie Donaghey

  • A high-resolution map of human evolutionary constraint using 29 mammals.

    Kerstin Lindblad-Toh;Manuel Garber;Or Zuk;Michael F. Lin;Michael F. Lin

  • Robust transcriptome-wide discovery of RNA-binding protein binding sites with enhanced CLIP (eCLIP)

    Eric L Van Nostrand;Gabriel A Pratt;Alexander A Shishkin;Chelsea Gelboin-Burkhart

  • Computational methods for transcriptome annotation and quantification using RNA-seq

    Manuel Garber;Manfred G Grabherr;Mitchell Guttman;Cole Trapnell;Cole Trapnell

  • Local regulation of gene expression by lncRNA promoters, transcription and splicing

    Jesse M. Engreitz;Jesse M. Engreitz;Jenna E. Haines;Elizabeth M. Perez;Glen Munson

  • Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells

    Sabine Loewer;Moran N Cabili;Moran N Cabili;Mitchell Guttman;Yuin-Han Loh

  • The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3

    Colleen A. McHugh;Chun-Kan Chen;Amy Chow;Christine F. Surka

  • The Xist lncRNA Exploits Three-Dimensional Genome Architecture to Spread Across the X Chromosome

    Jesse M. Engreitz;Amy Pandya-Jones;Patrick McDonel;Alexander Shishkin

  • Transcriptome-wide Mapping Reveals Widespread Dynamic-Regulated Pseudouridylation of ncRNA and mRNA

    Schraga Schwartz;Douglas A. Bernstein;Maxwell R. Mumbach;Marko Jovanovic

  • Ribosome Profiling Provides Evidence that Large Noncoding RNAs Do Not Encode Proteins

    Mitchell Guttman;Pamela Russell;Nicholas T. Ingolia;Jonathan S. Weissman

  • Higher-Order Inter-chromosomal Hubs Shape 3D Genome Organization in the Nucleus

    Sofia A. Quinodoz;Noah Ollikainen;Barbara Tabak;Ali Palla

  • The 4D nucleome project

    Job Dekker;Andrew S. Belmont;Mitchell Guttman;Victor O. Leshyk

  • Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre

    Ezgi Hacisuleyman;Loyal A Goff;Cole Trapnell;Adam Williams

Frequent Co-Authors

Eric S. Lander
Eric S. Lander Broad Institute
John L. Rinn
John L. Rinn University of Colorado Boulder
Manuel Garber
Manuel Garber University of Massachusetts Chan Medical School
Jesse M. Engreitz
Jesse M. Engreitz Stanford University
Bradley E. Bernstein
Bradley E. Bernstein Broad Institute
Ido Amit
Ido Amit Weizmann Institute of Science
Kathrin Plath
Kathrin Plath University of California, Los Angeles
Aviv Regev
Aviv Regev Genentech
Alexander Meissner
Alexander Meissner Max Planck Institute for Molecular Genetics
Andreas Gnirke
Andreas Gnirke Broad Institute

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