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Genetics

D-Index
74
Citations
71415
World Ranking
1920
National Ranking
879

Overview

Andreas Gnirke is affiliated with the Broad Institute in the United States. Their research spans several interconnected fields, primarily within Biochemistry, Genetics, and Molecular Biology, and Medicine. The scientist has concentrated on subfields including Molecular Biology, Epidemiology, Genetics, Infectious Diseases, and Cancer Research.

Their work addresses a variety of main topics, notably:

  • Epigenetics and DNA Methylation
  • Chronic Lymphocytic Leukemia Research
  • SARS-CoV-2 and COVID-19 Research
  • Genetic Syndromes and Imprinting
  • Cancer Genomics and Diagnostics
  • SARS-CoV-2 detection and testing
  • Fungal Infections and Studies

Gnirke has contributed to several publication venues, with the most frequent being bioRxiv (Cold Spring Harbor Laboratory), followed by Cell, Blood, Science, and Nature Genetics.

Recent notable publications include:

  • Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events, 2020, Science
  • TETs compete with DNMT3 activity in pluripotent cells at thousands of methylated somatic enhancers, 2020, Nature Genetics
  • Discovery of Candidate DNA Methylation Cancer Driver Genes, 2021, Cancer Discovery
  • DNA hypomethylation silences anti-tumor immune genes in early prostate cancer and CTCs, 2023, Cell
  • Smart-RRBS for single-cell methylome and transcriptome analysis, 2021, Nature Protocols

The list of frequent co-authors includes:

  • Alexander Meissner
  • Arman W. Mohammad
  • Catherine J. Wu
  • Laura Z. Rassenti
  • Donna Neuberg

The body of work by Gnirke reflects interdisciplinary approaches to molecular biology and medical research. Their studies encompass broad areas such as the genetic and epigenetic regulation mechanisms, particularly DNA methylation patterns in health and disease conditions, including cancer and infectious diseases like COVID-19.

Their involvement in SARS-CoV-2 research intersects both epidemiological and molecular perspectives, enhancing understanding of viral spread and diagnostic methods. Concurrently, Gnirke's contributions to cancer research focus on the epigenetic regulation of tumorigenesis and immune gene expression.

Overall, Andreas Gnirke's research profile is characterized by an integration of molecular genetics with clinical and epidemiological applications, supported by collaboration with several other researchers in related disciplines and published mainly in high-impact scientific journals and preprint servers.

Best Publications

  • Full-length transcriptome assembly from RNA-Seq data without a reference genome.

    Manfred G Grabherr;Brian J Haas;Moran Yassour;Moran Yassour;Joshua Z Levin

  • A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis

    J.N. Feder;A. Gnirke;W. Thomas;Z. Tsuchihashi

  • Genome-scale DNA methylation maps of pluripotent and differentiated cells

    Alexander Meissner;Tarjei S. Mikkelsen;Tarjei S. Mikkelsen;Hongcang Gu;Marius Wernig

  • High-quality draft assemblies of mammalian genomes from massively parallel sequence data

    Sante Gnerre;Iain MacCallum;Dariusz Przybylski;Filipe J. Ribeiro

  • Chromatin Extrusion Explains Key Features of Loop and Domain Formation in Wild‐type and Engineered Genomes

    Adrian Sanborn;Suhas Rao;Su‐Chen Huang;Neva Durand

  • Solution Hybrid Selection with Ultra-long Oligonucleotides for Massively Parallel Targeted Sequencing

    Andreas Gnirke;Alexandre Melnikov;Jared Maguire;Peter Rogov

  • The genome of the model beetle and pest Tribolium castaneum.

    Stephen Richards;Richard A. Gibbs;George M. Weinstock;Susan J. Brown

  • Charting a dynamic DNA methylation landscape of the human genome

    Michael J. Ziller;Hongcang Gu;Fabian Müller;Julie Donaghey;Julie Donaghey

  • Analyzing and minimizing PCR amplification bias in Illumina sequencing libraries

    Daniel Aird;Michael G Ross;Wei-Sheng Chen;Maxwell Danielsson

  • Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak

    Stephen K. Gire;Stephen K. Gire;Augustine Goba;Kristian G. Andersen;Kristian G. Andersen;Rachel S G Sealfon;Rachel S G Sealfon

  • Ab initio reconstruction of cell type–specific transcriptomes in mouse reveals the conserved multi-exonic structure of lincRNAs

    Mitchell Guttman;Manuel Garber;Joshua Z Levin;Julie Donaghey

  • Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis

    Jörg Kämper;Regine Kahmann;Michael Bölker;Li-Jun Ma

  • Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells

    Alex K. Shalek;Rahul Satija;Xian Adiconis;Rona S. Gertner

  • Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis

    Alexander Meissner;Andreas Gnirke;George W. Bell;Bernard H Ramsahoye

  • Reference Maps of Human ES and iPS Cell Variation Enable High-Throughput Characterization of Pluripotent Cell Lines

    Christoph Bock;Evangelos Kiskinis;Evangelos Kiskinis;Griet Verstappen;Griet Verstappen;Hongcang Gu

  • A unique regulatory phase of DNA methylation in the early mammalian embryo

    Zachary D. Smith;Michelle M. Chan;Michelle M. Chan;Tarjei Sigurd Mikkelsen;Tarjei Sigurd Mikkelsen;Hongcang Gu

  • Comprehensive comparative analysis of strand-specific RNA sequencing methods

    Joshua Z Levin;Moran Yassour;Moran Yassour;Xian Adiconis;Chad Nusbaum

  • Preparation of reduced representation bisulfite sequencing libraries for genome-scale DNA methylation profiling

    Hongcang Gu;Zachary D Smith;Zachary D Smith;Christoph Bock;Patrick Boyle

  • Targeted next-generation sequencing of a cancer transcriptome enhances detection of sequence variants and novel fusion transcripts

    Joshua Z Levin;Michael F Berger;Xian Adiconis;Peter Rogov

  • Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes

    Adrian Sanborn;Suhas Rao;Su-Chen Huang;Neva Durand

Frequent Co-Authors

Alexander Meissner
Alexander Meissner Max Planck Institute for Molecular Genetics
Eric S. Lander
Eric S. Lander Broad Institute
Hongcang Gu
Hongcang Gu Hefei Institutes of Physical Science
Joshua Z. Levin
Joshua Z. Levin Broad Institute
Tarjei S. Mikkelsen
Tarjei S. Mikkelsen Arsenal Biosciences (United States)
Pardis C. Sabeti
Pardis C. Sabeti Harvard University
Catherine J. Wu
Catherine J. Wu Harvard University
Bradley E. Bernstein
Bradley E. Bernstein Broad Institute
Kristian G. Andersen
Kristian G. Andersen Scripps Research Institute
Aviv Regev
Aviv Regev Genentech

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