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Microbiology

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Overview

David L. Narum is affiliated with the National Institutes of Health in the United States. Their research primarily focuses on malaria transmission and vaccine development within the fields of Medicine and Immunology and Microbiology. A significant portion of their work addresses public health concerns related to mosquito-borne diseases and immunological responses to parasites.

The main topics in their research include:

  • Malaria Research and Control
  • Mosquito-borne diseases and control
  • Invertebrate Immune Response Mechanisms
  • Complement system in diseases
  • HIV Research and Treatment
  • Vaccines and immunoinformatics approaches
  • Parasites and Host Interactions

The subfields that characterize their scientific contributions are:

  • Public Health, Environmental and Occupational Health
  • Immunology
  • Virology
  • Molecular Biology
  • Epidemiology

David L. Narum has published extensively in several scientific venues. Their frequent publication outlets include:

  • npj Vaccines
  • The Journal of Infectious Diseases
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Vaccine

Collaborative research is a notable aspect of their work, with frequent coauthors including:

  • Patrick E. Duffy
  • Olga Muratova
  • Kelly M. Rausch
  • Nicholas J. MacDonald
  • Lynn Lambert

Some of the recent papers authored or coauthored by David L. Narum include:

  • Pfs230 yields higher malaria transmission-blocking vaccine activity than Pfs25 in humans but not mice, 2021, Journal of Clinical Investigation
  • Structure and function of a malaria transmission blocking vaccine targeting Pfs230 and Pfs230-Pfs48/45 proteins, 2020, Communications Biology
  • A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes, 2021, Nature Communications
  • Malaria transmission-blocking vaccines Pfs230D1-EPA and Pfs25-EPA in Alhydrogel in healthy Malian adults; a phase 1, randomised, controlled trial, 2023, The Lancet Infectious Diseases
  • A human antibody epitope map of Pfs230D1 derived from analysis of individuals vaccinated with a malaria transmission-blocking vaccine, 2023, Immunity

Best Publications

  • A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray.

    Peter D Crompton;Matthew A Kayala;Boubacar Traore;Kassoum Kayentao

  • Phase 1 Trial of Malaria Transmission Blocking Vaccine Candidates Pfs25 and Pvs25 Formulated with Montanide ISA 51

    Yimin Wu;Ruth D. Ellis;Donna Shaffer;Erica Fontes

  • Differential localization of full-length and processed forms of PF83/AMA-1 an apical membrane antigen of Plasmodium falciparum merozoites

    David L. Narum;Alan W. Thomas;Alan W. Thomas

  • Binding of Plasmodium merozoite proteins RON2 and AMA1 triggers commitment to invasion

    Prakash Srinivasan;Wandy L. Beatty;Ababacar Diouf;Raul Herrera

  • The Plasmodium falciparum-Specific Human Memory B Cell Compartment Expands Gradually with Repeated Malaria Infections

    Greta E Weiss;Boubacar Zan Traoré;Kassoum Kayentao;Aissata Ongoiba

  • Identification and Prioritization of Merozoite Antigens as Targets of Protective Human Immunity to Plasmodium falciparum Malaria for Vaccine and Biomarker Development

    Jack Richards;Thangavelu U Arumugam;Linda Reiling;Julie Healer

  • Association between Naturally Acquired Antibodies to Erythrocyte-Binding Antigens of Plasmodium falciparum and Protection from Malaria and High-Density Parasitemia

    Jack S. Richards;Danielle I. Stanisic;Danielle I. Stanisic;Freya J. I. Fowkes;Livingstone Tavul

  • Endostatin Binds Tropomyosin A POTENTIAL MODULATOR OF THE ANTITUMOR ACTIVITY OF ENDOSTATIN

    Nicholas J. MacDonald;Wanda Y. Shivers;David L. Narum;Stacy M. Plum

  • Precise Timing of Expression of a Plasmodium falciparum- derived Transgene in Plasmodium berghei Is a Critical Determinant of Subsequent Subcellular Localization *

    Clemens H.M. Kocken;Anne Marie van der Wel;Martin A. Dubbeld;David L. Narum

  • Codon optimization of gene fragments encoding Plasmodium falciparum merzoite proteins enhances DNA vaccine protein expression and immunogenicity in mice.

    David L. Narum;Sanjai Kumar;William O. Rogers;Steven R. Fuhrmann

  • Structure of the Plasmodium falciparum circumsporozoite protein, a leading malaria vaccine candidate.

    Matthew L. Plassmeyer;Karine Reiter;Richard L. Shimp;Svetlana Kotova

  • Can prenatal malaria exposure produce an immune tolerant phenotype?: A prospective birth cohort study in Kenya

    Indu Malhotra;Arlene Elizabeth Dent;Peter Mungai;Alex Wamachi

  • Correlation of high levels of antibodies to multiple pre-erythrocytic Plasmodium falciparum antigens and protection from infection.

    Chandy C. John;Ann M. Moormann;Daniel C. Pregibon;Peter Odada Sumba

  • Protection of Aotus monkeys by Plasmodium falciparum EBA-175 region II DNA prime-protein boost immunization regimen.

    Trevor R. Jones;David L. Narum;Alfonso S. Gozalo;Joao Aguiar

  • Safety and Immunogenicity of Pfs25-EPA/Alhydrogel®, a Transmission Blocking Vaccine against Plasmodium falciparum: An Open Label Study in Malaria Naïve Adults.

    Kawsar R. Talaat;Ruth D. Ellis;Janet Hurd;Autumn Hentrich

  • Immunization with parasite-derived apical membrane antigen 1 or passive immunization with a specific monoclonal antibody protects BALB/c mice against lethal Plasmodium yoelii yoelii YM blood-stage infection

    David L. Narum;Solabomi A. Ogun;Alan W. Thomas;Anthony A. Holder

  • Conjugating recombinant proteins to Pseudomonas aeruginosa ExoProtein A: A strategy for enhancing immunogenicity of malaria vaccine candidates

    Feng Qian;Yimin Wu;Olga Muratova;Hong Zhou

  • NK cells inhibit plasmodium falciparum growth in red blood cells via antibody-dependent cellular cytotoxicity

    Gunjan Arora;Geoffrey T. Hart;Geoffrey T. Hart;Javier Manzella-Lapeira;Justin Y.A. Doritchamou

  • Antibodies to Plasmodium falciparum antigens predict a higher risk of malaria but protection from symptoms once parasitemic.

    Bryan Greenhouse;Benjamin Ho;Alan Hubbard;Denise Njama-Meya

  • Long-lasting and transmission-blocking activity of antibodies to Plasmodium falciparum elicited in mice by protein conjugates of Pfs25

    Joanna Kubler-Kielb;Fathy Majadly;Yimin Wu;David L. Narum

  • Disrupting malaria parasite AMA1-RON2 interaction with a small molecule prevents erythrocyte invasion

    Prakash Srinivasan;Adam Yasgar;Diane K. Luci;Wandy L. Beatty

  • Overproduction of Pichia pastoris or Plasmodium falciparum protein disulfide isomerase affects expression, folding and O-linked glycosylation of a malaria vaccine candidate expressed in P. pastoris

    Chiawei W. Tsai;Peter F. Duggan;Richard L. Shimp;Louis H. Miller

Frequent Co-Authors

Patrick E. Duffy
Patrick E. Duffy National Institute of Allergy and Infectious Diseases
Louis H. Miller
Louis H. Miller National Institute of Allergy and Infectious Diseases
Carole A. Long
Carole A. Long National Institute of Allergy and Infectious Diseases
James G. Beeson
James G. Beeson Burnet Institute
Kazutoyo Miura
Kazutoyo Miura National Institute of Allergy and Infectious Diseases
Michal Fried
Michal Fried National Institutes of Health
Freya J. I. Fowkes
Freya J. I. Fowkes Burnet Institute
Jack S. Richards
Jack S. Richards ZiP Diagnostics
Allan Saul
Allan Saul Burnet Institute
Peter D. Crompton
Peter D. Crompton National Institute of Allergy and Infectious Diseases

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