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Molecular Biology

D-Index
46
Citations
7238
World Ranking
2815
National Ranking
75

Overview

Marianne G. Rots is affiliated with the University Medical Center Groningen in the Netherlands. Their research spans broadly within biochemistry, genetics, and molecular biology with a significant focus on medicine. Their work includes substantial contributions to molecular biology, genetics, physiology, epidemiology, and surgery.

The researcher's main topics involve epigenetics and DNA methylation, CRISPR and genetic engineering, genetics and neurodevelopmental disorders, RNA modifications and cancer, pluripotent stem cells research, liver disease diagnosis and treatment, and adipose tissue and metabolism.

Frequent co-authors collaborating with Marianne G. Rots include:

  • Federica Sarno
  • Mihály Koncz
  • Lucia Altucci
  • Pernette J. Verschure
  • Louis Coussement

Marianne G. Rots has published multiple research papers in various scientific journals. Representative recent papers include:

  • Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes, 2021, Nature Communications
  • Advances of epigenetic editing, 2020, Current Opinion in Chemical Biology
  • Epigenetic Regulation of S100A9 and S100A12 Expression in Monocyte-Macrophage System in Hyperglycemic Conditions, 2020, Frontiers in Immunology
  • The Endothelium as a Target for Anti-Atherogenic Therapy: A Focus on the Epigenetic Enzymes EZH2 and SIRT1, 2021, Journal of Personalized Medicine
  • RASSF1C oncogene elicits amoeboid invasion, cancer stemness, and extracellular vesicle release via a SRC/Rho axis, 2021, The EMBO Journal

The researcher frequently publishes in the following venues:

  • International Journal of Molecular Sciences
  • Methods in molecular biology
  • Clinical Epigenetics
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Epigenetics Communications

Best Publications

  • EpCAM in carcinogenesis: the good, the bad or the ugly

    Bernardina T. F. van der Gun;Lieuwe J. Melchers;Marcel H. J. Ruiters;Lou F. M. H. de Leij

  • Expression of deoxycytidine kinase in leukaemic cells compared with solid tumour cell lines, liver metastases and normal liver.

    C.L. Van der Wilt;J.R. Kroep;W.J. Loves;Marianne Rots

  • Epigenetic reprogramming of cancer cells via targeted DNA methylation

    Ashley G. Rivenbark;Sabine Stolzenburg;Adriana S. Beltran;Xinni Yuan

  • The Timeline of Epigenetic Drug Discovery: From Reality to Dreams

    A. Ganesan;Paola B. Arimondo;Marianne G. Rots;Carmen Jeronimo

  • Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner

    David Cano-Rodriguez;Rutger A F. Gjaltema;Laura J Jilderda;Pytrick Jellema

  • Differential effects of NF-kappa B and p38 MAPK inhibitors and combinations thereof on TNF-alpha- and IL-1 beta-induced proinflammatory status of endothelial cells in vitro

    Joanna M. Kułdo;Johanna Westra;Sigridur A. Ásgeirsdóttir;Robbert J. Kok

  • Epigenetic Editing: targeted rewriting of epigenetic marks to modulate expression of selected target genes

    Marloes L. de Groote;Pernette J. Verschure;Marianne G. Rots

  • Different drug sensitivity profiles of acute myeloid and lymphoblastic leukemia and normal peripheral blood mononuclear cells in children with and without Down syndrome

    Christian M Zwaan;Gertjan J L Kaspers;Rob Pieters;Karel Hählen

  • Targeted silencing of the oncogenic transcription factor SOX2 in breast cancer

    Sabine Stolzenburg;Marianne G. Rots;Adriana S. Beltran;Ashley G. Rivenbark

  • Targeted Methylation and Gene Silencing of VEGF-A in Human Cells by Using a Designed Dnmt3a-Dnmt3L Single-Chain Fusion Protein with Increased DNA Methylation Activity

    Abu Nasar Siddique;Suneetha Nunna;Suneetha Nunna;Arumugam Rajavelu;Arumugam Rajavelu;Yingying Zhang

  • A Novel Strategy to Modify Adenovirus Tropism and Enhance Transgene Delivery to Activated Vascular Endothelial Cells In Vitro and In Vivo

    Ken Ichi Ogawara;Marianne G. Rots;Robbert J. Kok;Henk E. Moorlag

  • Role of folylpolyglutamate synthetase and folylpolyglutamate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia.

    Marianne G. Rots;Marianne G. Rots;Rob Pieters;Rob Pieters;Godefridus J. Peters;Godefridus J. Peters;Paul Noordhuis;Paul Noordhuis

  • Induced DNA demethylation by targeting Ten-Eleven Translocation 2 to the human ICAM-1 promoter

    Hui Chen;Hinke G Kazemier;Marloes L. de Groote;Marcel H. J. Ruiters

  • Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer's disease mice

    Fernando J Bustos;Estibaliz Ampuero;Nur Jury;Rodrigo Aguilar

  • Therapeutic modulation of endogenous gene function by agents with designed DNA-sequence specificities.

    Taco G. Uil;Hidde J. Haisma;Marianne G. Rots

  • The influence of eukaryotic chromatin state on CRISPR-Cas9 editing efficiencies

    Sebald An Verkuijl;Sebald An Verkuijl;Marianne G Rots

  • Mitochondrial epigenetics: an overlooked layer of regulation?

    Monique G.P. van der Wijst;Marianne G. Rots

  • mRNA expression levels of methotrexate resistance-related proteins in childhood leukemia as determined by a standardized competitive template-based RT-PCR method.

    M. Rots;J. Willey;Gert Jansen;C.H. van Zantwijk

  • Local chromatin microenvironment determines DNMT activity : from DNA methyltransferase to DNA demethylase or DNA dehydroxymethylase

    Monique G P van der Wijst;Muralidhar Venkiteswaran;Hui Chen;Guo-Liang Xu

  • Experimental mitochondria-targeted DNA methylation identifies GpC methylation, not CpG methylation, as potential regulator of mitochondrial gene expression

    Monique G. P. van der Wijst;Amanda Y. van Tilburg;Marcel H. J. Ruiters;Marianne G. Rots

Frequent Co-Authors

Hidde J. Haisma
Hidde J. Haisma University of Groningen
Rob Pieters
Rob Pieters Princess Máxima Center
Gerrit Jansen
Gerrit Jansen Amsterdam UMC
David T. Curiel
David T. Curiel Washington University in St. Louis
Godefridus J. Peters
Godefridus J. Peters Gdańsk Medical University
Geny M. M. Groothuis
Geny M. M. Groothuis University of Groningen
Grietje Molema
Grietje Molema University Medical Center Groningen
Albert Jeltsch
Albert Jeltsch University of Stuttgart
James C. Willey
James C. Willey University of Toledo

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