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Biology and Biochemistry

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72
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6310
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Overview

Grietje Molema is affiliated with the University Medical Center Groningen in the Netherlands. Their research primarily focuses on the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions in Immunology, Molecular Biology, Nephrology, Epidemiology, and Cancer Research.

Research topics frequently addressed in their work include:

  • Sepsis Diagnosis and Treatment
  • Acute Kidney Injury Research
  • Chronic Kidney Disease and Diabetes
  • Angiogenesis and VEGF in Cancer
  • MicroRNA in disease regulation
  • Phagocytosis and Immune Regulation
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms

Their recent papers encompass the following:

  • Renal microvascular endothelial cell responses in sepsis-induced acute kidney injury, 2021, Nature Reviews Nephrology
  • Development of a Combined Lipid-Based Nanoparticle Formulation for Enhanced siRNA Delivery to Vascular Endothelial Cells, 2022, Pharmaceutics
  • Unlocking the Untapped Potential of Endothelial Kinase and Phosphatase Involvement in Sepsis for Drug Treatment Design, 2022, Frontiers in Immunology
  • Pharmacological inhibition of focal adhesion kinase 1 (FAK1) and anaplastic lymphoma kinase (ALK) identified via kinome profile analysis attenuates lipopolysaccharide-induced endothelial inflammatory activation, 2020, Biomedicine & Pharmacotherapy
  • Pharmacological inhibition of protein tyrosine kinases axl and fyn reduces TNF-α-induced endothelial inflammatory activation in vitro, 2022, Frontiers in Pharmacology

Frequent coauthors collaborating in their research include:

  • Matijs van Meurs
  • Matthijs Luxen
  • Jill Moser
  • Peter J. Zwiers
  • Rianne M. Jongman

Publication venues where their work is often published include:

  • Zenodo (CERN European Organization for Nuclear Research)
  • PLoS ONE
  • American Journal of Physiology-Renal Physiology
  • Nature Reviews Nephrology
  • Pharmaceutics

Best Publications

  • Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle

    Raymond M. Schiffelers;Aslam Ansari;Jun Xu;Qin Zhou

  • Angiogenesis: Potentials for Pharmacologic Intervention in the Treatment of Cancer, Cardiovascular Diseases, and Chronic Inflammation

    Arjan W. Griffioen;Grietje Molema

  • Tumor Infarction in Mice by Antibody-Directed Targeting of Tissue Factor to Tumor Vasculature

    Xianming Huang;Grietje Molema;Grietje Molema;Steven King;Linda Watkins

  • Antiviral activities of lactoferrin

    B.W.A van der Strate;L Beljaars;G Molema;M.C Harmsen

  • RGD-based strategies for selective delivery of therapeutics and imaging agents to the tumour vasculature

    Kai Temming;Raymond M. Schiffelers;Grietje Molema;Robbert J. Kok

  • Endothelium in vitro: a review of human vascular endothelial cell lines for blood vessel-related research.

    Diane Bouïs;Geke A.P. Hospers;Coby Meijer;Grietje Molema

  • Potential cellular and molecular causes of hypertrophic scar formation

    Willem M. van der Veer;Monica C.T. Bloemen;Magda M.W. Ulrich;Grietje Molema

  • Anti-tumor efficacy of tumor vasculature-targeted liposomal doxorubicin

    Raymond M Schiffelers;Gerben A Koning;Timo L M ten Hagen;Marcel H A M Fens

  • A liposomal system for contrast-enhanced magnetic resonance imaging of molecular targets.

    Willem J. M. Mulder;Gustav J. Strijkers;Arjan W. Griffioen;Louis Van Bloois

  • Pericyte migration - A novel mechanism of pericyte loss in experimental diabetic retinopathy

    Frederick Pfister;Yuxi Feng;Franziska vom Hagen;Sigrid Hoffmann

  • In Vivo Characteristics of Cationic Liposomes as Delivery Vectors for Gene Therapy

    Sandrine A. L. Audouy;Lou F. M. H. de Leij;Dick Hoekstra;Grietje Molema

  • Generating hypotheses by discovering implicit associations in the literature: a case report of a search for new potential therapeutic uses for thalidomide.

    Marc Weeber;Rein Vos;Henny Klein;Lolkje T. W. de Jong-van den Berg

  • Targeting of angiogenic endothelial cells at sites of inflammation by dexamethasone phosphate-containing RGD peptide liposomes inhibits experimental arthritis.

    Gerben A. Koning;Raymond M. Schiffelers;Marca H. M. Wauben;Robbert J. Kok

  • Albumin modified with mannose 6-phosphate: A potential carrier for selective delivery of antifibrotic drugs to rat and human hepatic stellate cells.

    Leonie Beljaars;Grietje Molema;Betty Weert;Harmke Bonnema

  • Differential effects of NF-kappa B and p38 MAPK inhibitors and combinations thereof on TNF-alpha- and IL-1 beta-induced proinflammatory status of endothelial cells in vitro

    Joanna M. Kułdo;Johanna Westra;Sigridur A. Ásgeirsdóttir;Robbert J. Kok

  • Preparation and functional evaluation of RGD-modified proteins as alpha(v)beta(3) integrin directed therapeutics.

    Robbert J Kok;Astrid J Schraa;Erwin J Bos;Henk E Moorlag

  • Relationship between duration of brain death and hemodynamic (in)stability on progressive dysfunction and increased immunologic activation of donor kidneys

    Joost A.B. van Der Hoeven;Grietje Molema;Gert J. Ter Horst;Reni L. Freund

  • Successful Targeting to Rat Hepatic Stellate Cells Using Albumin Modified with Cyclic Peptides That Recognize the Collagen Type VI Receptor

    Leonie Beljaars;Grietje Molema;D Schuppan;A Geerts

  • The effect of surgical wounding on tumour development.

    S.O.P. Hofer;G. Molema;R.A.E.C. Hermens;H.J. Wanebo

  • A Novel Strategy to Modify Adenovirus Tropism and Enhance Transgene Delivery to Activated Vascular Endothelial Cells In Vitro and In Vivo

    Ken Ichi Ogawara;Marianne G. Rots;Robbert J. Kok;Henk E. Moorlag

Frequent Co-Authors

Dirk K. F. Meijer
Dirk K. F. Meijer University of Groningen
Peter Heeringa
Peter Heeringa University Medical Center Groningen
Gert Storm
Gert Storm Utrecht University
Raymond M. Schiffelers
Raymond M. Schiffelers Utrecht University
William C. Aird
William C. Aird Beth Israel Deaconess Medical Center
Michel Struys
Michel Struys University Medical Center Groningen
Elisabeth Verpoorte
Elisabeth Verpoorte University of Groningen
Wijnand Helfrich
Wijnand Helfrich University Medical Center Groningen
Hidde J. Haisma
Hidde J. Haisma University of Groningen
Martin C. Harmsen
Martin C. Harmsen University Medical Center Groningen

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