Wijnand Helfrich

Overview

Best Publications

• Expression of the gastrin-releasing peptide receptor, the prostate stem cell antigen and the prostate-specific membrane antigen in lymph node and bone metastases of prostate cancer.

  Hildo J.K. Ananias;Marius C. van den Heuvel;Wijnand Helfrich;Igle J. de Jong

  206
  Citations

• Therapeutic potential of Galectin-9 in human disease.

  Valerie R. Wiersma;Marco de Bruyn;Wijnand Helfrich;Edwin Bremer

  181
  Citations

• A recombinant, fully human monoclonal antibody with antitumor activity constructed from phage-displayed antibody fragments

  Gerwin Huls;Iafm Heijnen;ME Cuomo;JC Koningsberger

  172
  Citations

• Targeted induction of apoptosis for cancer therapy: current progress and prospects

  Edwin Bremer;Go van Dam;Bart Jan Kroesen;Lou de Leij

  167
  Citations

• Simultaneous Inhibition of Epidermal Growth Factor Receptor (EGFR) Signaling and Enhanced Activation of Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Receptor-mediated Apoptosis Induction by an scFv:sTRAIL Fusion Protein with Specificity for Human EGFR

  Edwin Bremer;Douwe F. Samplonius;Linda van Genne;Marike H. Dijkstra

  153
  Citations

• Target cell-restricted apoptosis induction of acute leukemic T cells by a recombinant tumor necrosis factor-related apoptosis-inducing ligand fusion protein with specificity for human CD7

  Edwin Bremer;Douwe F. Samplonius;Matthias Peipp;Linda van Genne

  131
  Citations

• Carbon monoxide-Releasing Molecule-2 (CORM-2) attenuates acute hepatic ischemia reperfusion injury in rats

  Yunwei Wei;Yunwei Wei;Ping Chen;Marco de Bruyn;Weihui Zhang

  130
  Citations

• Target cell-restricted and -enhanced apoptosis induction by a scFv:sTRAIL fusion protein with specificity for the pancarcinoma-associated antigen EGP2.

  Edwin Bremer;Jos Kuijlen;Douwe Samplonius;Henning Walczak

  123
  Citations

• Wnt2 acts as a cell type-specific, autocrine growth factor in rat hepatic sinusoidal endothelial cells cross-stimulating the VEGF pathway.

  Daniel Klein;Alexandra Demory;Francis Peyre;Jens Kroll

  121
  Citations

• Dual-Modality Image-Guided Surgery of Prostate Cancer with a Radiolabeled Fluorescent Anti-PSMA Monoclonal Antibody

  Susanne Lutje;Mark Rijpkema;Gerben M. Franssen;Giulio Fracasso

  116
  Citations

• Fas Receptor Clustering and Involvement of the Death Receptor Pathway in Rituximab-Mediated Apoptosis with Concomitant Sensitization of Lymphoma B Cells to Fas-Induced Apoptosis

  Alja J. Stel;Bram ten Cate;Susan Jacobs;Jan Willem Kok

  113
  Citations

• Nuclear imaging of prostate cancer with gastrin-releasing-peptide-receptor targeted radiopharmaceuticals.

  H. J. K. Ananias;de Igle Jan Jong;Rudi Dierckx;C. van de Wiele

  95
  Citations

• A novel AML-selective TRAIL fusion protein that is superior to Gemtuzumab Ozogamicin in terms of in vitro selectivity, activity and stability.

  B. ten Cate;Edwin Bremer;M. de Bruyn;Theo Bijma

  88
  Citations

• Melanoma-associated Chondroitin Sulfate Proteoglycan (MCSP)-targeted delivery of soluble TRAIL potently inhibits melanoma outgrowth in vitro and in vivo

  Marco de Bruyn;Anna A. Rybczynska;Yunwei Wei;Yunwei Wei;Michael Schwenkert

  87
  Citations

• Review: on TRAIL for malignant glioma therapy?

  J. M. A. Kuijlen;E. Bremer;J. J. A. Mooij;W. F. A. den Dunnen

  86
  Citations

• High-affinity recombinant phage antibodies to the pan-carcinoma marker epithelial glycoprotein-2 for tumour targeting

  RC Roovers;P Henderikx;Wijnand Helfrich;E van der Linden

  85
  Citations

• Antibody-based fusion proteins to target death receptors in cancer

  Marco de Bruyn;Edwin Bremer;Wijnand Helfrich

  84
  Citations

• Approaches to lung cancer treatment using the CD3E x GP-2-directed bispecific monoclonal antibody BIS-1

  Bart Kroesen;J Nieken;Dirk Sleijfer;Grietje Molema

  84
  Citations

• Frequency of Th17 CD20+cells in the peripheral blood of rheumatoid arthritis patients is higher compared to healthy subjects

  Paul Eggleton;Edwin Bremer;Joanna M Tarr;Marco de Bruyn

  79
  Citations

• Construction and characterization of a bispecific diabody for retargeting T cells to human carcinomas

  Wijnand Helfrich;Bart Jan Kroesen;Rob C. Roovers;Lidia Westers

  78
  Citations