World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
85
Citations
25538
World Ranking
2677
National Ranking
926

Research.com Recognitions

  • 2010 - Fellow of American Physical Society (APS) Citation For his pioneering contributions to theoretical and computational biophysics, in particular by developing elegent theories and methods on proteinligand binding and the effects of intracellular environment on biophysical properties of proteins
  • 2008 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Huan-Xiang Zhou is affiliated with the University of Illinois at Chicago in the United States and has made contributions primarily in the field of Biochemistry, Genetics, and Molecular Biology. Their work encompasses a broad range of topics with a particular focus on molecular and cellular biophysics.

The scientist's research emphasizes key topics such as:

  • Protein Structure and Dynamics
  • RNA Research and Splicing
  • RNA and protein synthesis mechanisms
  • Enzyme Structure and Function
  • Lipid metabolism and biosynthesis
  • Alzheimer's disease research and treatments
  • RNA modifications and cancer

Their subfields of study reveal a multidisciplinary approach, including Molecular Biology, Materials Chemistry, Physiology, Electrical and Electronic Engineering, and Spectroscopy. This breadth reflects a comprehensive engagement with both fundamental biological processes and experimental techniques.

Huan-Xiang Zhou has collaborated extensively with a number of frequent co-authors, including:

  • Ramesh Prasad
  • Sanbo Qin
  • Souvik Dey
  • Matthew MacAinsh
  • Timothy A. Cross

Publications are commonly found in notable venues such as bioRxiv (Cold Spring Harbor Laboratory), Biophysical Journal, arXiv (Cornell University), PubMed, and Communications Biology.

Recent representative papers include:

  • "Shear relaxation governs fusion dynamics of biomolecular condensates", 2021, Nature Communications
  • "Microplastic contamination in the agricultural soil-mitigation strategies, heavy metals contamination, and impact on human health: a review", 2024, Plant Cell Reports
  • "Determinants for Fusion Speed of Biomolecular Droplets", 2020, Angewandte Chemie International Edition
  • "Fundamental Aspects of Phase-Separated Biomolecular Condensates", 2024, Chemical Reviews
  • "Artificial intelligence guided conformational mining of intrinsically disordered proteins", 2022, Communications Biology

The scientist has also contributed to scholarly books, including a publication with Springer Science+Business Media titled Phase-Separated Biomolecular Condensates in 2022.

Recognition for their work includes awards such as:

  • Fellow of the American Physical Society (APS), 2010, noted for contributions to theoretical and computational biophysics, including advances in protein-ligand binding theories and studies of intracellular environment effects on protein biophysical properties
  • Fellow of the American Association for the Advancement of Science (AAAS), 2008

Best Publications

  • Macromolecular Crowding and Confinement: Biochemical, Biophysical, and Potential Physiological Consequences*

    Huan-Xiang Zhou;Germ ´ an Rivas;Allen P. Minton

  • Calculation of protein-ligand binding affinities.

    Michael K Gilson;Huan-Xiang Zhou

  • Electrostatic Interactions in Protein Structure, Folding, Binding, and Condensation

    Huan-Xiang Zhou;Xiaodong Pang

  • Fundamental aspects of protein-protein association kinetics.

    G. Schreiber;G. Haran;H. X. Zhou

  • Insight into the Mechanism of the Influenza A Proton Channel from a Structure in a Lipid Bilayer

    Mukesh Sharma;Myunggi Yi;Hao Dong;Huajun Qin

  • Stabilization of Proteins in Confined Spaces

    Huan-Xiang Zhou;Ken A. Dill

  • Protein Allostery and Conformational Dynamics.

    Jingjing Guo;Huan-Xiang Zhou

  • Theory of free energy and entropy in noncovalent binding.

    Huan-Xiang Zhou;Michael K. Gilson

  • Prediction of protein interaction sites from sequence profile and residue neighbor list

    Huan-Xiang Zhou;Yibing Shan

  • Prediction of interface residues in protein-protein complexes by a consensus neural network method: test against NMR data.

    Huiling Chen;Huan-Xiang Zhou

  • Demonstration of positionally disordered water within a protein hydrophobic cavity by NMR.

    J. A. Ernst;R. T. Clubb;Huan-Xiang Zhou;A. M. Gronenborn

  • Conformation gating as a mechanism for enzyme specificity

    Huan-Xiang Zhou;Stanislaw T. Wlodek;J. Andrew McCammon

  • Influences of Membrane Mimetic Environments on Membrane Protein Structures

    Huan-Xiang Zhou;Timothy A. Cross

  • Histidines, heart of the hydrogen ion channel from influenza A virus: toward an understanding of conductance and proton selectivity.

    Jun Hu;Riqiang Fu;Katsuyuki Nishimura;Li Zhang

  • meta-PPISP

    Sanbo Qin;Huan-Xiang Zhou

  • Interaction-site prediction for protein complexes

    Huan-Xiang Zhou;Sanbo Qin

  • Electrostatic enhancement of diffusion-controlled protein-protein association: comparison of theory and experiment on barnase and barstar.

    Muthusamy Vijayakumar;Kwan Y. Wong;Gideon Schreiber;Alan R. Fersht

  • Influence of Solubilizing Environments on Membrane Protein Structures

    Timothy A. Cross;Mukesh Sharma;Myunggi Yi;Huan-Xiang Zhou

  • Protein folding and binding in confined spaces and in crowded solutions

    Huan-Xiang Zhou

  • Influence of crowded cellular environments on protein folding, binding, and oligomerization: Biological consequences and potentials of atomistic modeling

    Huan-Xiang Zhou

Frequent Co-Authors

Timothy A. Cross
Timothy A. Cross Florida State University
Attila Szabo
Attila Szabo National Institutes of Health
Ivan Hung
Ivan Hung University of Hong Kong
Gideon Schreiber
Gideon Schreiber Weizmann Institute of Science
Paul A. Bates
Paul A. Bates The Francis Crick Institute
Jeffrey J. Gray
Jeffrey J. Gray Johns Hopkins University
Juan Fernández-Recio
Juan Fernández-Recio Spanish National Research Council
Thom Vreven
Thom Vreven Visterra (United States)
Shoshana J. Wodak
Shoshana J. Wodak Vrije Universiteit Brussel
Zhiping Weng
Zhiping Weng University of Massachusetts Chan Medical School

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