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D-Index & Metrics

Chemistry

D-Index
69
Citations
13910
World Ranking
6341
National Ranking
1925

Research.com Recognitions

  • 2006 - National Institutes of Health Director's Pioneer Award

Overview

Gary J. Pielak is affiliated with the University of North Carolina at Chapel Hill in the United States. Their research primarily spans the fields of biochemistry, genetics, and molecular biology, with a strong focus on molecular biology as a subfield. The scientist's work addresses multiple areas within these disciplines, particularly protein structure and dynamics, enzyme structure and function, and protein purification and stability.

The main topics covered in their research include:

  • Protein Structure and Dynamics
  • Enzyme Structure and Function
  • Tardigrade Biology and Ecology
  • Spaceflight Effects on Biology
  • Protein Purification and Stability
  • Parkinson's Disease Mechanisms and Treatments
  • Biocrusts and Microbial Ecology

Gary J. Pielak has published research in several notable venues, with the highest number of publications appearing in UNC Libraries, OPAL (Open@LaTrobe) at La Trobe University, Biophysical Journal, Protein Science, and Biochemistry.

Their recent published papers include:

  • Macromolecular Crowding Is More than Hard-Core Repulsions, 2022, Annual Review of Biophysics
  • The Intracellular Environment Affects Protein-Protein Interactions, 2021, Proceedings of the National Academy of Sciences
  • How Sugars Protect Dry Protein Structure, 2023, Biochemistry
  • Rapid Quantification of Protein-Ligand Binding via 19F NMR Lineshape Analysis, 2020, Biophysical Journal
  • Protein-complex Stability in Cells and in Vitro under Crowded Conditions, 2020, Current Opinion in Structural Biology

Collaboration is an integral part of their work, with frequent co-authors including Conggang Li, Julia A. Brom, Gregory B. Young, Daniel Harries, and Candice J. Crilly.

Gary J. Pielak received the National Institutes of Health Director's Pioneer Award in 2006, signifying recognition within the scientific community.

Best Publications

  • Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs).

    Francois Xavier Theillet;Andres Binolfi;Tamara Frembgen-Kesner;Karan Hingorani

  • Tardigrades Use Intrinsically Disordered Proteins to Survive Desiccation

    Thomas C. Boothby;Hugo Tapia;Alexandra H. Brozena;Samantha Piszkiewicz

  • Impact of protein denaturants and stabilizers on water structure.

    Joseph D. Batchelor;Alina Olteanu;and Ashutosh Tripathy;Gary J. Pielak

  • Macromolecular Crowding and Protein Stability

    Yaqiang Wang;Mohona Sarkar;Austin E. Smith;Alexander S. Krois

  • FlgM gains structure in living cells

    Matthew M. Dedmon;Chetan N. Patel;Gregory B. Young;Gary J. Pielak

  • Protein crowding tunes protein stability.

    Andrew C. Miklos;Mohona Sarkar;Yaqiang Wang;Gary J. Pielak

  • Interpreting the effects of small uncharged solutes on protein-folding equilibria.

    Paula R. Davis-Searles;Aleister J. Saunders;Dorothy A. Erie;Donald J. Winzor

  • Effects of Proteins on Protein Diffusion

    Yaqiang Wang;Conggang Li;Gary J. Pielak

  • Soft interactions and crowding.

    Mohona Sarkar;Conggang Li;Gary J. Pielak

  • Protein 19F NMR in Escherichia coli

    Conggang Li;Gui Fang Wang;Yaqiang Wang;Rachel Creager-Allen

  • Unexpected effects of macromolecular crowding on protein stability.

    Laura A. Benton;Austin E. Smith;Gregory B. Young;Gary J. Pielak

  • Macromolecular Crowding in the Escherichia coli Periplasm Maintains α-Synuclein Disorder

    Brian C. McNulty;Gregory B. Young;Gary J. Pielak

  • Quinary structure modulates protein stability in cells

    William B. Monteith;Rachel D. Cohen;Austin E. Smith;Emilio Guzman-Cisneros

  • Solvent-induced collapse of α-synuclein and acid-denatured cytochrome c

    Artemiza S. Morar;Alina Olteanu;Gregory B. Young;Gary J. Pielak

  • Impact of reconstituted cytosol on protein stability

    Mohona Sarkar;Austin E. Smith;Gary J. Pielak

  • Site-directed mutagenesis of cytochrome c shows that an invariant Phe is not essential for function.

    Gary J. Pielak;A. Grant Mauk;Michael Smith

  • Volume exclusion and soft interaction effects on protein stability under crowded conditions.

    Andrew C. Miklos;Conggang Li;Naima G. Sharaf;Gary J. Pielak

  • Osmolyte-induced changes in protein conformational equilibria.

    Aleister J. Saunders;Paula R. Davis-Searles;Devon L. Allen;Gary J. Pielak

  • In-cell thermodynamics and a new role for protein surfaces.

    Austin E. Smith;Larry Z. Zhou;Annelise H. Gorensek;Michael Senske

  • Replacement of cysteine-107 of Saccharomyces cerevisiae iso-1-cytochrome c with threonine: improved stability of the mutant protein.

    R.L. Cutler;G.J. Pielak;A. G. Mauk;M. Smith

  • Differential dynamical effects of macromolecular crowding on an intrinsically disordered protein and a globular protein: implications for in-cell NMR spectroscopy

    Conggang Li;Lisa M. Charlton;Asha Lakkavaram;Christopher Seagle

Frequent Co-Authors

Robert J. P. Williams
Robert J. P. Williams University of Oxford
Marshall H. Edgell
Marshall H. Edgell University of North Carolina at Chapel Hill
Francis Millett
Francis Millett University of Arkansas at Fayetteville
Bob Goldstein
Bob Goldstein University of North Carolina at Chapel Hill
michael smith
michael smith Royal Geographical Society
Bin Jiang
Bin Jiang Chinese Academy of Sciences
Kevin M. Weeks
Kevin M. Weeks University of North Carolina at Chapel Hill
Donald J. Winzor
Donald J. Winzor University of Queensland
Dorothy A. Erie
Dorothy A. Erie University of North Carolina at Chapel Hill
A. Grant Mauk
A. Grant Mauk University of British Columbia

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