World's Best Scientists 2026 revealed!
Mitsuru Hashida

Mitsuru Hashida

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Biology and Biochemistry
Japan
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
96
Citations
30027
World Ranking
1844
National Ranking
103

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2025 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2023 - Research.com Biology and Biochemistry in Japan Leader Award

Overview

Mitsuru Hashida is affiliated with Kyoto University in Japan and has contributed to the field of Biochemistry, Genetics and Molecular Biology through various research works focusing on molecular biology, biomedical engineering, pharmacology, immunology, and genetics. Their research broadly addresses RNA interference and gene delivery, immunotherapy and immune responses, virus-based gene therapy research, advancements in transdermal drug delivery, lipid membrane structure and behavior, nanoparticle-based drug delivery, and nanoplatforms for cancer theranostics.

Their recent papers include the following:

  • Role of pharmacokinetic consideration for the development of drug delivery systems: A historical overview, 2020, Advanced Drug Delivery Reviews
  • Advocation and advancements of EPR effect theory in drug delivery science: A commentary, 2022, Journal of Controlled Release
  • Development of a DNA Vaccine for Melanoma Metastasis by Inhalation Based on an Analysis of Transgene Expression Characteristics of Naked pDNA and a Ternary Complex in Mouse Lung Tissues, 2020, Pharmaceutics
  • Effects of Tissue Pressure on Transgene Expression Characteristics via Renal Local Administration Routes from Ureter or Renal Artery in the Rat Kidney, 2020, Pharmaceutics
  • Evaluation of transgene expression characteristics and DNA vaccination against melanoma metastasis of an intravenously injected ternary complex with biodegradable dendrigraft poly-L-lysine in mice, 2021, Drug Delivery

Frequent publication venues for Mitsuru Hashida include Pharmaceutics, Advanced Drug Delivery Reviews, Journal of Controlled Release, Drug Delivery, and PLoS ONE.

The scientist has collaborated often with several co-authors in the field, including Shigeru Kawakami, Fumiyoshi Yamashita, Mikiro Nakashima, Natsuko Oyama, and Yukinobu Kodama.

Best Publications

  • The fate of plasmid DNA after intravenous injection in mice: involvement of scavenger receptors in its hepatic uptake.

    Kenji Kawabata;Yoshinobu Takakura;Mitsuru Hashida

  • Mannose receptor-mediated gene transfer into macrophages using novel mannosylated cationic liposomes

    S. Kawakami;A. Sato;Makiya Nishikawa;F. Yamashita

  • The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier.

    Takashi Kageyama;Masaru Nakamura;Akinori Matsuo;Yasuomi Yamasaki

  • Defective stratum corneum and early neonatal death in mice lacking the gene for transglutaminase 1 (keratinocyte transglutaminase)

    Masato Matsuki;Fumiyoshi Yamashita;Akemi Ishida-Yamamoto;Keiko Yamada

  • Macromolecular carrier systems for targeted drug delivery: pharmacokinetic considerations on biodistribution.

    Yoshinobu Takakura;Mitsuru Hashida

  • Disposition characteristics of macromolecules in tumor-bearing mice.

    Yoshinobu Takakura;Takuya Fujita;Mitsuru Hashida;Hitoshi Sezaki

  • Luminescent proteins for high-speed single-cell and whole-body imaging

    Kenta Saito;Y. F. Chang;Kazuki Horikawa;Noriyuki Hatsugai;Noriyuki Hatsugai

  • Novel PEG-matrix metalloproteinase-2 cleavable peptide-lipid containing galactosylated liposomes for hepatocellular carcinoma-selective targeting.

    Takeshi Terada;Mieko Iwai;Shigeru Kawakami;Fumiyoshi Yamashita

  • Disposition and Tumor Localization of Mitomycin C–Dextran Conjugates in Mice

    Yoshinobu Takakura;Akira Takagi;Mitsuru Hashida;Hitoshi Sezaki

  • Cell-specific delivery of genes with glycosylated carriers.

    Mitsuru Hashida;Makiya Nishikawa;Fumiyoshi Yamashita;Yoshinobu Takakura

  • In silico approaches for predicting ADME properties of drugs.

    Fumiyoshi Yamashita;Mitsuru Hashida

  • Interaction between DNA–cationic liposome complexes and erythrocytes is an important factor in systemic gene transfer via the intravenous route in mice: the role of the neutral helper lipid

    F Sakurai;T Nishioka;H Saito;T Baba

  • In vivo gene delivery to the liver using novel galactosylated cationic liposomes.

    Shigeru Kawakami;Shintaro Fumoto;Makiya Nishikawa;Fumiyoshi Yamashita

  • Molecular weight-dependent gene transfection activity of unmodified and galactosylated polyethyleneimine on hepatoma cells and mouse liver

    Kensuke Morimoto;Makiya Nishikawa;Shigeru Kawakami;Takayuki Nakano

  • Catalase delivery for inhibiting ROS-mediated tissue injury and tumor metastasis.

    Makiya Nishikawa;Mitsuru Hashida;Yoshinobu Takakura

  • Effect of DNA/liposome mixing ratio on the physicochemical characteristics, cellular uptake and intracellular trafficking of plasmid DNA/cationic liposome complexes and subsequent gene expression

    Fuminori Sakurai;Rui Inoue;Yasunobu Nishino;Ayumu Okuda

  • Asialoglycoprotein Receptor-Mediated Gene Transfer Using Novel Galactosylated Cationic Liposomes

    Shigeru Kawakami;Fumiyoshi Yamashita;Makiya Nishikawa;Yoshinobu Takakura

  • Transport of cephalexin to the cerebrospinal fluid directly from the nasal cavity.

    Toshiyasu Sakane;Motohiro Akizuki;Masako Yoshida;Shinji Yamashita

  • Targeted delivery of plasmid DNA complexed with galactosylated poly(L-lysine).

    Mitsuru Hashida;Shigeo Takemura;Makiya Nishikawa;Yoshinobu Takakura

  • Physicochemical and pharmacokinetic characteristics of plasmid DNA/cationic liposome complexes

    Ram I. Mahato;Kenji Kawabata;Takehiko Nomura;Yoshinobu Takakura

Frequent Co-Authors

Fumiyoshi Yamashita
Fumiyoshi Yamashita Kyoto University
Yoshinobu Takakura
Yoshinobu Takakura Kyoto University
Shigeru Kawakami
Shigeru Kawakami Nagasaki University
Hitoshi Sezaki
Hitoshi Sezaki Kyoto University
Makiya Nishikawa
Makiya Nishikawa Tokyo University of Science
Ram I. Mahato
Ram I. Mahato University of Nebraska Medical Center
Takuya Fujita
Takuya Fujita Ritsumeikan University
Hiroshi Imahori
Hiroshi Imahori Kyoto University
Makoto Kiso
Makoto Kiso Gifu University
Takuro Niidome
Takuro Niidome Kumamoto University

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