World's Best Scientists 2026 revealed!
Takeharu Nagai

Takeharu Nagai

D-Index & Metrics

Biology and Biochemistry

D-Index
67
Citations
24191
World Ranking
8068
National Ranking
544

Overview

Takeharu Nagai is affiliated with Osaka University in Japan and has an extensive publication record primarily in the fields of Biochemistry, Genetics, and Molecular Biology. Their research covers 139 publications with significant contributions in the subfields of Molecular Biology, Biophysics, Biomedical Engineering, Cellular and Molecular Neuroscience, and Cell Biology.

The scientist's research interests include several advanced topics such as:

  • Advanced Fluorescence Microscopy Techniques
  • Bioluminescence and Chemiluminescence Research
  • Cell Image Analysis Techniques
  • Photoreceptor and Optogenetics Research
  • Biosensors and Analytical Detection
  • Advanced Biosensing and Bioanalysis Techniques
  • Neuroscience and Neuropharmacology Research

Takeharu Nagai has published in a variety of scientific venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biophysics and Physicobiology
  • Scientific Reports
  • Communications Biology
  • eLife

The following are some recent papers illustrating the breadth of their work:

  • "LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury" (2020) in Nature Cell Biology
  • "Stepwise synaptic plasticity events drive the early phase of memory consolidation" (2021) in Science
  • "Exploring rare cellular activity in more than one million cells by a transscale scope" (2021) in Scientific Reports
  • "Palmitoylated CKAP4 regulates mitochondrial functions through an interaction with VDAC2 at ER-mitochondria contact sites" (2020) in Journal of Cell Science
  • "Intracellular Heat Transfer and Thermal Property Revealed by Kilohertz Temperature Imaging with a Genetically Encoded Nanothermometer" (2022) in Nano Letters

The scientist frequently collaborates with several researchers, including:

  • Tomoki Matsuda
  • Tetsuichi Wazawa
  • Mitsuru Hattori
  • Taishi Kakizuka
  • Taro Ichimura

Best Publications

  • A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications

    Takeharu Nagai;Keiji Ibata;Eun Sun Park;Mie Kubota

  • An Expanded Palette of Genetically Encoded Ca2+ Indicators

    Yongxin Zhao;Satoko Araki;Jiahui Wu;Takayuki Teramoto

  • Circularly permuted green fluorescent proteins engineered to sense Ca2

    Takeharu Nagai;Asako Sawano;Eun Sun Park;Atsushi Miyawaki

  • Expanded dynamic range of fluorescent indicators for Ca(2+) by circularly permuted yellow fluorescent proteins.

    Takeharu Nagai;Shuichi Yamada;Takashi Tominaga;Michinori Ichikawa

  • Visualization of ATP levels inside single living cells with fluorescence resonance energy transfer-based genetically encoded indicators

    Hiromi Imamura;Kim P. Huynh Nhat;Hiroko Togawa;Kenta Saito

  • Rapid and persistent modulation of actin dynamics regulates postsynaptic reorganization underlying bidirectional plasticity.

    Ken-Ichi Okamoto;Takeharu Nagai;Atsushi Miyawaki;Yasunori Hayashi

  • Spatio-temporal images of growth-factor-induced activation of Ras and Rap1.

    Naoki Mochizuki;Shigeko Yamashita;Kazuo Kurokawa;Yusuke Ohba

  • THE EXPRESSION OF THE MOUSE ZIC1, ZIC2, AND ZIC3 GENE SUGGESTS AN ESSENTIAL ROLE FOR ZIC GENES IN BODY PATTERN FORMATION

    Takeharu Nagai;Jun Aruga;Shinji Takada;Thomas Günther

  • Dynamic Organization of Chromatin Domains Revealed by Super-Resolution Live-Cell Imaging

    Tadasu Nozaki;Ryosuke Imai;Mai Tanbo;Mai Tanbo;Ryosuke Nagashima;Ryosuke Nagashima

  • Cyan-emitting and orange-emitting fluorescent proteins as a donor/acceptor pair for fluorescence resonance energy transfer

    Satoshi Karasawa;Toshio Araki;Takeharu Nagai;Hideaki Mizuno

  • Spontaneous network activity visualized by ultrasensitive Ca 2+ indicators, yellow Cameleon-Nano

    Kazuki Horikawa;Yoshiyuki Yamada;Tomoki Matsuda;Kentarou Kobayashi

  • Spatio-temporal activation of caspase revealed by indicator that is insensitive to environmental effects

    Kiwamu Takemoto;Takeharu Nagai;Takeharu Nagai;Atsushi Miyawaki;Masayuki Miura

  • Luminescent proteins for high-speed single-cell and whole-body imaging

    Kenta Saito;Y. F. Chang;Kazuki Horikawa;Noriyuki Hatsugai;Noriyuki Hatsugai

  • Functional fluorescent Ca2+ indicator proteins in transgenic mice under TET control.

    Mazahir T Hasan;Rainer W Friedrich;Thomas Euler;Matthew E Larkum

  • The Mouse Zic Gene Family HOMOLOGUES OF THE DROSOPHILA PAIR-RULE GENE odd-paired

    Jun Aruga;Takeharu Nagai;Tsutomu Tokuyama;Yoshihide Hayashizaki

  • Xenopus Zic3, a primary regulator both in neural and neural crest development

    Katsunori Nakata;Takeharu Nagai;Jun Aruga;Katsuhiko Mikoshiba

  • Five colour variants of bright luminescent protein for real-time multicolour bioimaging

    Kazushi Suzuki;Taichi Kimura;Hajime Shinoda;Guirong Bai

  • Zic2 regulates the kinetics of neurulation

    Takeharu Nagai;Jun Aruga;Osamu Minowa;Takashi Sugimoto

  • Improved Orange and Red Ca2+ Indicators and Photophysical Considerations for Optogenetic Applications

    Jiahui Wu;Lin Liu;Tomoki Matsuda;Yongxin Zhao

  • Crystal Structure of Venus, a Yellow Fluorescent Protein with Improved Maturation and Reduced Environmental Sensitivity

    Agata Rekas;Jean-René Alattia;Takeharu Nagai;Takeharu Nagai;Atsushi Miyawaki

Frequent Co-Authors

Katsuhiko Mikoshiba
Katsuhiko Mikoshiba ShanghaiTech University
Jun Aruga
Jun Aruga Nagasaki University
Hiroyuki Noji
Hiroyuki Noji University of Tokyo
Katsumi Imada
Katsumi Imada Osaka University
Naoto Ueno
Naoto Ueno National Institute for Basic Biology
Megumi Iwano
Megumi Iwano Nara Institute of Science and Technology
Hiroyuki Kagi
Hiroyuki Kagi University of Tokyo
Hitoshi Hashimoto
Hitoshi Hashimoto Osaka University
Satoshi Kawata
Satoshi Kawata Osaka University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Pursuing a degree in Biology or Biochemistry opens the door to numerous advanced career opportunities, especially with the growing demand for healthcare professionals and researchers. Many students are now considering online degrees, thanks to their flexibility and accessibility for working adults and career changers.

Those interested in healthcare management may explore top online mha programs that are cahme accredited for a strong foundation in hospital administration and leadership skills. Graduates can advance into roles as healthcare managers and executives.

For those seeking advanced clinical roles, several online dnp programs without clinicals allow experienced nurses to enhance their expertise while balancing professional responsibilities.

If your interests align with research or senior healthcare leadership, consider an doctorate in healthcare administration online to develop advanced analytical and policy-making skills.

Similarly, science graduates looking to transition into pharmacy can explore online pharmd programs for non pharmacists, designed for those without a pharmacy background but with a strong interest in medicine and patient care.

Best Scientists Citing Takeharu Nagai

Trending Scientists

Recently Published Articles